The effects of n-3 long-chain polyunsaturated fatty acids on bone formation and growth factors in adolescent boys

Camilla Trab Damsgaard; Christian Mølgaard; Jeppe Matthiessen; Sedsel N Gyldenløve; Lotte Lauritzen

doi:10.1038/pr.2012.28

The effects of n-3 long-chain polyunsaturated fatty acids on bone formation and growth factors in adolescent boys

Camilla Trab Damsgaard, Christian Mølgaard, Jeppe Matthiessen, Sedsel N Gyldenløve, Lotte Lauritzen

25 Citationer (Scopus)

Abstract

Introduction: Animal studies indicate that n-3 long-chain polyunsaturated fatty acids (LCPUFAs) increase bone formation. To our knowledge, no studies have examined this in growing humans. This study investigated whether bone mass and markers of bone formation and growth were (i) associated with docosahexaenoic acid (DHA) status and (ii) affected by fish oil supplementation, in adolescent boys. Methods: Seventy-eight healthy, slightly overweight 13-to 15-y-old boys were randomly assigned to breads with DHA-rich fish oil (1.1g/d n-3 LCPUFA) or control for 16wk. Whole-body bone mineral content (BMC), bone area (BA), bone mineral density (BMD), plasma osteocalcin, and growth factors were measured at wk 0 and wk 16, as well as diet, physical activity, and n-3 LCPUFA status in erythrocytes. Results: Fish oil strongly increased DHA status (P = 0.0001). No associations were found between DHA status and BMC, BA, BMD, or the markers of bone formation and growth at baseline. Furthermore, the fish oil intervention did not affect any of the outcomes as compared with control. However, dose-response analyses revealed a positive association between changes in DHA status and plasma insulin-like growth factor-1 (IGF-1) during intervention (Β = 0.24, P = 0.03, n = 78). Discussion: DHA status and fish oil supplementation were not associated with bone mass or markers of bone formation in adolescent boys, but IGF-1 increased with increasing DHA status.

Originalsprog	Engelsk
Tidsskrift	Pediatric Research
Vol/bind	71
Udgave nummer	6
Sider (fra-til)	713-719
Antal sider	7
ISSN	0031-3998
DOI	https://doi.org/10.1038/pr.2012.28
Status	Udgivet - jun. 2012

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10.1038/pr.2012.28

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abstract = "Introduction: Animal studies indicate that n-3 long-chain polyunsaturated fatty acids (LCPUFAs) increase bone formation. To our knowledge, no studies have examined this in growing humans. This study investigated whether bone mass and markers of bone formation and growth were (i) associated with docosahexaenoic acid (DHA) status and (ii) affected by fish oil supplementation, in adolescent boys. Methods: Seventy-eight healthy, slightly overweight 13-to 15-y-old boys were randomly assigned to breads with DHA-rich fish oil (1.1g/d n-3 LCPUFA) or control for 16wk. Whole-body bone mineral content (BMC), bone area (BA), bone mineral density (BMD), plasma osteocalcin, and growth factors were measured at wk 0 and wk 16, as well as diet, physical activity, and n-3 LCPUFA status in erythrocytes. Results: Fish oil strongly increased DHA status (P = 0.0001). No associations were found between DHA status and BMC, BA, BMD, or the markers of bone formation and growth at baseline. Furthermore, the fish oil intervention did not affect any of the outcomes as compared with control. However, dose-response analyses revealed a positive association between changes in DHA status and plasma insulin-like growth factor-1 (IGF-1) during intervention (Β = 0.24, P = 0.03, n = 78). Discussion: DHA status and fish oil supplementation were not associated with bone mass or markers of bone formation in adolescent boys, but IGF-1 increased with increasing DHA status.",

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AU - Gyldenløve, Sedsel N

AU - Lauritzen, Lotte

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N2 - Introduction: Animal studies indicate that n-3 long-chain polyunsaturated fatty acids (LCPUFAs) increase bone formation. To our knowledge, no studies have examined this in growing humans. This study investigated whether bone mass and markers of bone formation and growth were (i) associated with docosahexaenoic acid (DHA) status and (ii) affected by fish oil supplementation, in adolescent boys. Methods: Seventy-eight healthy, slightly overweight 13-to 15-y-old boys were randomly assigned to breads with DHA-rich fish oil (1.1g/d n-3 LCPUFA) or control for 16wk. Whole-body bone mineral content (BMC), bone area (BA), bone mineral density (BMD), plasma osteocalcin, and growth factors were measured at wk 0 and wk 16, as well as diet, physical activity, and n-3 LCPUFA status in erythrocytes. Results: Fish oil strongly increased DHA status (P = 0.0001). No associations were found between DHA status and BMC, BA, BMD, or the markers of bone formation and growth at baseline. Furthermore, the fish oil intervention did not affect any of the outcomes as compared with control. However, dose-response analyses revealed a positive association between changes in DHA status and plasma insulin-like growth factor-1 (IGF-1) during intervention (Β = 0.24, P = 0.03, n = 78). Discussion: DHA status and fish oil supplementation were not associated with bone mass or markers of bone formation in adolescent boys, but IGF-1 increased with increasing DHA status.

AB - Introduction: Animal studies indicate that n-3 long-chain polyunsaturated fatty acids (LCPUFAs) increase bone formation. To our knowledge, no studies have examined this in growing humans. This study investigated whether bone mass and markers of bone formation and growth were (i) associated with docosahexaenoic acid (DHA) status and (ii) affected by fish oil supplementation, in adolescent boys. Methods: Seventy-eight healthy, slightly overweight 13-to 15-y-old boys were randomly assigned to breads with DHA-rich fish oil (1.1g/d n-3 LCPUFA) or control for 16wk. Whole-body bone mineral content (BMC), bone area (BA), bone mineral density (BMD), plasma osteocalcin, and growth factors were measured at wk 0 and wk 16, as well as diet, physical activity, and n-3 LCPUFA status in erythrocytes. Results: Fish oil strongly increased DHA status (P = 0.0001). No associations were found between DHA status and BMC, BA, BMD, or the markers of bone formation and growth at baseline. Furthermore, the fish oil intervention did not affect any of the outcomes as compared with control. However, dose-response analyses revealed a positive association between changes in DHA status and plasma insulin-like growth factor-1 (IGF-1) during intervention (Β = 0.24, P = 0.03, n = 78). Discussion: DHA status and fish oil supplementation were not associated with bone mass or markers of bone formation in adolescent boys, but IGF-1 increased with increasing DHA status.

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The effects of n-3 long-chain polyunsaturated fatty acids on bone formation and growth factors in adolescent boys

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