Synthesis of the thiazole-thiazoline fragment of largazole analogues

Frederik Diness; Daniel Skovhaur Nielsen; David P Fairlie

doi:10.1021/jo201675r

Synthesis of the thiazole-thiazoline fragment of largazole analogues

Frederik Diness, Daniel Skovhaur Nielsen, David P Fairlie

19 Citationer (Scopus)

Abstract

The thiazole-thiazoline fragment of the marine natural product largazole, a potent histone deacetylase 1 inhibitor, has been synthesized in five steps. The methodology provides rapid access to thiazole-4-carbonitrile, thiazole-4-carbimidate, thiazole-oxazoline, and other thiazole-thiazoline derivatives that are important intermediates in the total synthesis of many natural products with important biological properties.

Originalsprog	Engelsk
Tidsskrift	Journal of Organic Chemistry
Vol/bind	76
Udgave nummer	23
Sider (fra-til)	9845-9851
ISSN	0022-3263
DOI	https://doi.org/10.1021/jo201675r
Status	Udgivet - 2 dec. 2011

Emneord

Det tidligere Farmaceutiske Fakultet

FN’s Verdensmål

Dette resultat bidrager til følgende verdensmål

Adgang til dokumentet

10.1021/jo201675r

Citationsformater

@article{0a082f98f66a44759c5e94637f4f1f51,

title = "Synthesis of the thiazole-thiazoline fragment of largazole analogues",

abstract = "The thiazole-thiazoline fragment of the marine natural product largazole, a potent histone deacetylase 1 inhibitor, has been synthesized in five steps. The methodology provides rapid access to thiazole-4-carbonitrile, thiazole-4-carbimidate, thiazole-oxazoline, and other thiazole-thiazoline derivatives that are important intermediates in the total synthesis of many natural products with important biological properties.",

keywords = "Former Faculty of Pharmaceutical Sciences",

author = "Frederik Diness and Nielsen, {Daniel Skovhaur} and Fairlie, {David P}",

year = "2011",

month = dec,

day = "2",

doi = "10.1021/jo201675r",

language = "English",

volume = "76",

pages = "9845--9851",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

number = "23",

}

TY - JOUR

T1 - Synthesis of the thiazole-thiazoline fragment of largazole analogues

AU - Diness, Frederik

AU - Nielsen, Daniel Skovhaur

AU - Fairlie, David P

PY - 2011/12/2

Y1 - 2011/12/2

N2 - The thiazole-thiazoline fragment of the marine natural product largazole, a potent histone deacetylase 1 inhibitor, has been synthesized in five steps. The methodology provides rapid access to thiazole-4-carbonitrile, thiazole-4-carbimidate, thiazole-oxazoline, and other thiazole-thiazoline derivatives that are important intermediates in the total synthesis of many natural products with important biological properties.

AB - The thiazole-thiazoline fragment of the marine natural product largazole, a potent histone deacetylase 1 inhibitor, has been synthesized in five steps. The methodology provides rapid access to thiazole-4-carbonitrile, thiazole-4-carbimidate, thiazole-oxazoline, and other thiazole-thiazoline derivatives that are important intermediates in the total synthesis of many natural products with important biological properties.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1021/jo201675r

DO - 10.1021/jo201675r

M3 - Journal article

C2 - 22032297

SN - 0022-3263

VL - 76

SP - 9845

EP - 9851

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 23

ER -

Synthesis of the thiazole-thiazoline fragment of largazole analogues

Abstract

Emneord

FN’s Verdensmål

Adgang til dokumentet

Fingeraftryk

Citationsformater