Synthesis of the thiazole-thiazoline fragment of largazole analogues

Frederik Diness; Daniel Skovhaur Nielsen; David P Fairlie

doi:10.1021/jo201675r

Synthesis of the thiazole-thiazoline fragment of largazole analogues

Frederik Diness, Daniel Skovhaur Nielsen, David P Fairlie

19 Citations (Scopus)

Abstract

The thiazole-thiazoline fragment of the marine natural product largazole, a potent histone deacetylase 1 inhibitor, has been synthesized in five steps. The methodology provides rapid access to thiazole-4-carbonitrile, thiazole-4-carbimidate, thiazole-oxazoline, and other thiazole-thiazoline derivatives that are important intermediates in the total synthesis of many natural products with important biological properties.

Original language	English
Journal	Journal of Organic Chemistry
Volume	76
Issue number	23
Pages (from-to)	9845-9851
ISSN	0022-3263
DOIs	https://doi.org/10.1021/jo201675r
Publication status	Published - 2 Dec 2011

Keywords

Former Faculty of Pharmaceutical Sciences

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/jo201675r

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abstract = "The thiazole-thiazoline fragment of the marine natural product largazole, a potent histone deacetylase 1 inhibitor, has been synthesized in five steps. The methodology provides rapid access to thiazole-4-carbonitrile, thiazole-4-carbimidate, thiazole-oxazoline, and other thiazole-thiazoline derivatives that are important intermediates in the total synthesis of many natural products with important biological properties.",

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KW - Former Faculty of Pharmaceutical Sciences

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Synthesis of the thiazole-thiazoline fragment of largazole analogues

Abstract

Keywords

UN SDGs

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