Synthesis of C-terminal peptide thioesters using Fmoc-based solid-phase peptide chemistry

Anne Pernille Tofteng Shelton, Knud Jørgen Jensen

3 Citationer (Scopus)

Abstract

This chapter provides two protocols for the solid-phase synthesis of peptide thioesters using N α -Fmoc-protected amino acids. The first protocol is based on a so-called safety-catch linker, while the second relies on a backbone amide linker.

OriginalsprogEngelsk
TitelPeptide synthesis and applications
RedaktørerKnud J. Jensen, Pernille T. Shelton, Søren L. Pedersen
Antal sider11
ForlagHumana Press
Publikationsdato2013
Sider119-129
ISBN (Trykt)978-1-62703-543-9
ISBN (Elektronisk)978-1-62703-544-6
DOI
StatusUdgivet - 2013
NavnMethods in Molecular Biology
Vol/bind1047
ISSN1064-3745

Emneord

  • Backbone amide linker
  • Handle
  • Peptide
  • Aldehyde
  • Thioester
  • N-Alkyl amide
  • Cyclic peptide
  • Reductive amination

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