Synthesis of C-terminal peptide thioesters using Fmoc-based solid-phase peptide chemistry

Anne Pernille Tofteng Shelton; Knud Jørgen Jensen

doi:10.1007/978-1-62703-544-6_8

Synthesis of C-terminal peptide thioesters using Fmoc-based solid-phase peptide chemistry

Anne Pernille Tofteng Shelton, Knud Jørgen Jensen

Department of Chemistry

3 Citations (Scopus)

Abstract

This chapter provides two protocols for the solid-phase synthesis of peptide thioesters using N ^α -Fmoc-protected amino acids. The first protocol is based on a so-called safety-catch linker, while the second relies on a backbone amide linker.

Original language	English
Title of host publication	Peptide synthesis and applications
Editors	Knud J. Jensen, Pernille T. Shelton, Søren L. Pedersen
Number of pages	11
Publisher	Humana Press
Publication date	2013
Pages	119-129
ISBN (Print)	978-1-62703-543-9
ISBN (Electronic)	978-1-62703-544-6
DOIs	https://doi.org/10.1007/978-1-62703-544-6_8
Publication status	Published - 2013

Series	Methods in Molecular Biology
Volume	1047
ISSN	1064-3745

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Synthesis of C-terminal peptide thioesters using Fmoc-based solid-phase peptide chemistry. / Shelton, Anne Pernille Tofteng; Jensen, Knud Jørgen.

Peptide synthesis and applications. ed. / Knud J. Jensen; Pernille T. Shelton; Søren L. Pedersen. Humana Press, 2013. p. 119-129 (Methods in Molecular Biology, Vol. 1047).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

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Synthesis of C-terminal peptide thioesters using Fmoc-based solid-phase peptide chemistry

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