Synthesis and structure-activity studies on acidic amino acids and related diacids as NMDA receptor ligands

Medicin og biovidenskab

• 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid 0%
• Acidic Amino Acids 63%
• alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 26%
• Amino Acids 7%
• AMPA Receptors 6%
• aspartic acid receptor 50%
• Glutamic Acid 4%
• Inhibitory Concentration 50 4%
• Ligands 29%
• Mechanics 5%
• N-acetylalanyl-N-methylamide 100%
• N-Methylaspartate 45%
• Nitrogen 5%
• propionic acid 6%
• Quinolinic Acid 7%

Kemiske forbindelser

• (S)-AMPA 21%
• Acetic Acid 7%
• Acid 14%
• Agonist 20%
• Amino Groups 8%
• Antagonist 9%
• Bioactivity 7%
• Flexibility 8%
• Ligand 18%
• Methoxy Group 11%
• Molecular Mechanic 10%
• N Methyl Dextro Aspartic Acid Receptor Stimulating Agent 38%
• N-Methyl-D-Aspartic Acid 73%
• Neurotoxic 13%
• Nitrogen Atom 8%
• Propionic Acid 11%
• Quinolinic Acid 16%