@article{0aebbd4eaf0d4806838f4bda1a219124,
title = "Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties",
abstract = "This Letter describes the first account of the synthesis and SAR, developed through an iterative analogue library approach, of analogues of the highly selective M1 allosteric agonist TBPB. With slight structural changes, mAChR selectivity was maintained, but the degree of partial M1 agonism varied considerably.",
keywords = "Acetylcholine/chemistry, Allosteric Regulation, Allosteric Site, Benzimidazoles/chemical synthesis, Binding Sites, Chemistry, Pharmaceutical/methods, Dose-Response Relationship, Drug, Drug Design, Humans, Inhibitory Concentration 50, Ligands, Models, Chemical, Piperidines/chemical synthesis, Receptor, Muscarinic M1/chemistry, Structure-Activity Relationship, Time Factors",
author = "Bridges, {Thomas M} and Brady, {Ashley E} and Kennedy, {J Phillip} and Daniels, {R Nathan} and Miller, {Nicole R} and Kwango Kim and Breininger, {Micah L} and Gentry, {Patrick R} and Brogan, {John T} and Jones, {Carrie K} and Conn, {P Jeffrey} and Lindsley, {Craig W}",
year = "2008",
month = oct,
day = "15",
doi = "10.1016/j.bmcl.2008.09.023",
language = "English",
volume = "18",
pages = "5439--42",
journal = "Bioorganic & Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Pergamon Press",
number = "20",
}