@article{f6164d08cf7c41308e1d1b15c7969d98,
title = "Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)",
abstract = "This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson's disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a number of analogs of VU0155041.",
keywords = "Allosteric Regulation/drug effects, Allosteric Site, Anilides/chemical synthesis, Animals, Cyclohexanecarboxylic Acids/chemical synthesis, Disease Models, Animal, Parkinson Disease/drug therapy, Rats, Receptors, Metabotropic Glutamate/chemistry, Structure-Activity Relationship",
author = "Richard Williams and Johnson, {Kari A} and Gentry, {Patrick R} and Niswender, {Colleen M} and Weaver, {Charles D} and Conn, {P Jeffrey} and Lindsley, {Craig W} and Hopkins, {Corey R}",
year = "2009",
month = sep,
day = "1",
doi = "10.1016/j.bmcl.2009.07.072",
language = "English",
volume = "19",
pages = "4967--70",
journal = "Bioorganic & Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Pergamon Press",
number = "17",
}