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Subnanomolar antisense activity of phosphonate-peptide nucleic acid (PNA) conjugates delivered by cationic lipids to HeLa cells.
Takehiko Shiraishi, Ramin Hamzavi,
Peter E Nielsen
Transcription, RNA, and Gene Medicine Program
Institut for Cellulær og Molekylær Medicin
63
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Keyphrases
Nucleic Acid Conjugates
100%
Subnanomolar
100%
Cationic Lipids
100%
Cellular Delivery
18%
Oligophosphonates
9%
Amino Acid Derivatives
9%
Sequence Discrimination
9%
Nucleic Acid Targets
9%
Antisense Peptide
9%
In Vivo Bioavailability
9%
Splice Correction
9%
HexA
9%
Affinity-based
9%
Gene Therapeutics
9%
Lipofectamine
9%
Target Binding
9%
Pharmacology, Toxicology and Pharmaceutical Science
Phosphonate
100%
Lipofectamine
9%
Messenger RNA Precursor
9%
Heteroduplex
9%
Thermostability
9%
Amino Acid Derivative
9%
Biochemistry, Genetics and Molecular Biology
Cationic Lipid
100%
Lipofectamine
9%