Structure-specific endonucleases: guardians of fragile site stability

Sheroy Minocherhomji; Ian D Hickson

doi:10.1016/j.tcb.2013.11.007

Structure-specific endonucleases: guardians of fragile site stability

Sheroy Minocherhomji, Ian D Hickson

28 Citationer (Scopus)

Abstract

Fragile sites are conserved loci predisposed to form breaks in metaphase chromosomes. The inherent instability of these loci is associated with chromosomal rearrangements in cancers and is a feature of cells from patients with chromosomal instability syndromes. One class of fragile sites, the common fragile sites (CFSs), have previously been shown to recruit several DNA repair proteins after the completion of bulk DNA synthesis in the cell, probably indicative of their inability to complete timely DNA replication. CFS loci are also prone to trigger mitotic non-disjunction of sister chromatids, leading to the formation of ultra-fine anaphase bridges (UFBs) and micronuclei. We discuss recent developments in the CFS field; in particular, the role of DNA structure-specific endonucleases in promoting cleavage at CFSs.

Originalsprog	Engelsk
Tidsskrift	Trends in Cell Biology
Vol/bind	24
Udgave nummer	5
Sider (fra-til)	321-327
Antal sider	7
ISSN	0962-8924
DOI	https://doi.org/10.1016/j.tcb.2013.11.007
Status	Udgivet - maj 2014

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10.1016/j.tcb.2013.11.007

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title = "Structure-specific endonucleases: guardians of fragile site stability",

abstract = "Fragile sites are conserved loci predisposed to form breaks in metaphase chromosomes. The inherent instability of these loci is associated with chromosomal rearrangements in cancers and is a feature of cells from patients with chromosomal instability syndromes. One class of fragile sites, the common fragile sites (CFSs), have previously been shown to recruit several DNA repair proteins after the completion of bulk DNA synthesis in the cell, probably indicative of their inability to complete timely DNA replication. CFS loci are also prone to trigger mitotic non-disjunction of sister chromatids, leading to the formation of ultra-fine anaphase bridges (UFBs) and micronuclei. We discuss recent developments in the CFS field; in particular, the role of DNA structure-specific endonucleases in promoting cleavage at CFSs.",

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T2 - guardians of fragile site stability

AU - Minocherhomji, Sheroy

AU - Hickson, Ian D

PY - 2014/5

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N2 - Fragile sites are conserved loci predisposed to form breaks in metaphase chromosomes. The inherent instability of these loci is associated with chromosomal rearrangements in cancers and is a feature of cells from patients with chromosomal instability syndromes. One class of fragile sites, the common fragile sites (CFSs), have previously been shown to recruit several DNA repair proteins after the completion of bulk DNA synthesis in the cell, probably indicative of their inability to complete timely DNA replication. CFS loci are also prone to trigger mitotic non-disjunction of sister chromatids, leading to the formation of ultra-fine anaphase bridges (UFBs) and micronuclei. We discuss recent developments in the CFS field; in particular, the role of DNA structure-specific endonucleases in promoting cleavage at CFSs.

AB - Fragile sites are conserved loci predisposed to form breaks in metaphase chromosomes. The inherent instability of these loci is associated with chromosomal rearrangements in cancers and is a feature of cells from patients with chromosomal instability syndromes. One class of fragile sites, the common fragile sites (CFSs), have previously been shown to recruit several DNA repair proteins after the completion of bulk DNA synthesis in the cell, probably indicative of their inability to complete timely DNA replication. CFS loci are also prone to trigger mitotic non-disjunction of sister chromatids, leading to the formation of ultra-fine anaphase bridges (UFBs) and micronuclei. We discuss recent developments in the CFS field; in particular, the role of DNA structure-specific endonucleases in promoting cleavage at CFSs.

U2 - 10.1016/j.tcb.2013.11.007

DO - 10.1016/j.tcb.2013.11.007

M3 - Journal article

C2 - 24361091

SN - 0962-8924

VL - 24

SP - 321

EP - 327

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 5

ER -

Structure-specific endonucleases: guardians of fragile site stability

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