Structure-revealing data fusion model with applications in metabolomics

TY - GEN

T1 - Structure-revealing data fusion model with applications in metabolomics

AU - Evrim, Acar Ataman

AU - Lawaetz, Anders Juul

AU - Rasmussen, Morten Arendt

AU - Bro, Rasmus

N1 - Conference code: 35

PY - 2013

Y1 - 2013

N2 - In many disciplines, data from multiple sources are acquired and jointly analyzed for enhanced knowledge discovery. For instance, in metabolomics, different analytical techniques are used to measure biological fluids in order to identify the chemicals related to certain diseases. It is widely-known that, some of these analytical methods, e.g., LC-MS (Liquid Chromatography - Mass Spectrometry) and NMR (Nuclear Magnetic Resonance) spectroscopy, provide complementary data sets and their joint analysis may enable us to capture a larger proportion of the complete metabolome belonging to a specific biological system. Fusing data from multiple sources has proved useful in many fields including bioinformatics, signal processing and social network analysis. However, identification of common (shared) and individual (unshared) structures across multiple data sets remains a major challenge in data fusion studies. With a goal of addressing this challenge, we propose a novel unsupervised data fusion model. Our contributions are two-fold: (i) We formulate a data fusion model based on joint factorization of matrices and higher-order tensors, which can automatically reveal common and individual components. (ii) We demonstrate that the proposed approach provides promising results in joint analysis of metabolomics data sets consisting of fluorescence and NMR measurements of plasma samples in terms of separation of colorectal cancer patients from controls.

AB - In many disciplines, data from multiple sources are acquired and jointly analyzed for enhanced knowledge discovery. For instance, in metabolomics, different analytical techniques are used to measure biological fluids in order to identify the chemicals related to certain diseases. It is widely-known that, some of these analytical methods, e.g., LC-MS (Liquid Chromatography - Mass Spectrometry) and NMR (Nuclear Magnetic Resonance) spectroscopy, provide complementary data sets and their joint analysis may enable us to capture a larger proportion of the complete metabolome belonging to a specific biological system. Fusing data from multiple sources has proved useful in many fields including bioinformatics, signal processing and social network analysis. However, identification of common (shared) and individual (unshared) structures across multiple data sets remains a major challenge in data fusion studies. With a goal of addressing this challenge, we propose a novel unsupervised data fusion model. Our contributions are two-fold: (i) We formulate a data fusion model based on joint factorization of matrices and higher-order tensors, which can automatically reveal common and individual components. (ii) We demonstrate that the proposed approach provides promising results in joint analysis of metabolomics data sets consisting of fluorescence and NMR measurements of plasma samples in terms of separation of colorectal cancer patients from controls.

U2 - 10.1109/embc.2013.6610925

DO - 10.1109/embc.2013.6610925

M3 - Conference article

C2 - 24111112

SN - 2375-7477

VL - 35

SP - 6023

EP - 6026

JO - I E E E Engineering in Medicine and Biology Society. Conference Proceedings

JF - I E E E Engineering in Medicine and Biology Society. Conference Proceedings

T2 - Annual International Conference of the IEEE 2013

Y2 - 3 July 2013 through 7 July 2013

ER -