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Structural insight to mutation effects uncover a common allosteric site in class C GPCRs
Kasper Harpsøe
, Michael W Boesgaard, Christian Munk,
Hans Bräuner-Osborne
,
David E Gloriam
8
Citationer (Scopus)
77
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Keyphrases
Allosteric Site
100%
Mutation Effect
100%
Structural Insights
100%
Experimental Structure
33%
New Therapeutics
33%
Large Potential
33%
Orphan Receptor
33%
Positive Modulator
33%
Rational Design
33%
Negative Modulators
33%
Food Industry
33%
Site-directed mutagenesis
33%
Physiological Function
33%
High Similarity
33%
Allosteric Modulator
33%
Transmembrane Domain
33%
Amino Acids
33%
Biochemistry, Genetics and Molecular Biology
Allosteric Site
100%
G Protein Coupled Receptor
100%
Transmembrane Domain
33%
Orphan Receptor
33%
Site-Directed Mutagenesis
33%
Crystal Structure
33%
Amino Acid
33%