Structural basis of cell-cell adhesion by NCAM

C Kasper; H Rasmussen; Jette Sandholm Jensen Kastrup; S Ikemizu; E Y Jones; V Berezin; E Bock; I K Larsen

doi:10.1038/75165

Structural basis of cell-cell adhesion by NCAM

C Kasper, H Rasmussen, Jette Sandholm Jensen Kastrup, S Ikemizu, E Y Jones, V Berezin, E Bock, I K Larsen

Eyepath Lab

109 Citationer (Scopus)

Abstract

The neural cell adhesion molecule NCAM, a member of the immunoglobulin superfamily, mediates cell-cell recognition and adhesion via a homophilic interaction. NCAM plays a key role during development and regeneration of the nervous system and is involved in synaptic plasticity associated with memory and learning. The 1.85 A crystal structure of the two N-terminal extracellular domains of NCAM reported here provides a structural basis for the homophilic interaction. The molecular packing of the two-domain structure reveals a cross shaped antiparallel dimer, and provides fundamental insight into trans-cellular recognition mediated by NCAM.

Originalsprog	Engelsk
Tidsskrift	Nature Structural and Molecular Biology
Vol/bind	7
Udgave nummer	5
Sider (fra-til)	389-393
Antal sider	5
ISSN	1545-9993
DOI	https://doi.org/10.1038/75165
Status	Udgivet - 2000

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10.1038/75165

Citationsformater

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title = "Structural basis of cell-cell adhesion by NCAM",

abstract = "The neural cell adhesion molecule NCAM, a member of the immunoglobulin superfamily, mediates cell-cell recognition and adhesion via a homophilic interaction. NCAM plays a key role during development and regeneration of the nervous system and is involved in synaptic plasticity associated with memory and learning. The 1.85 A crystal structure of the two N-terminal extracellular domains of NCAM reported here provides a structural basis for the homophilic interaction. The molecular packing of the two-domain structure reveals a cross shaped antiparallel dimer, and provides fundamental insight into trans-cellular recognition mediated by NCAM.",

keywords = "Amino Acid Sequence, Animals, Binding Sites, Calcium, Cell Adhesion, Crystallography, X-Ray, Dimerization, Heparin, Hydrogen Bonding, Immunoglobulins, Models, Molecular, Molecular Sequence Data, Neural Cell Adhesion Molecules, Protein Binding, Protein Structure, Secondary, Protein Structure, Tertiary, Rats, Sequence Alignment, Structure-Activity Relationship",

author = "C Kasper and H Rasmussen and Kastrup, {Jette Sandholm Jensen} and S Ikemizu and Jones, {E Y} and V Berezin and E Bock and Larsen, {I K}",

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TY - JOUR

T1 - Structural basis of cell-cell adhesion by NCAM

AU - Kasper, C

AU - Rasmussen, H

AU - Kastrup, Jette Sandholm Jensen

AU - Ikemizu, S

AU - Jones, E Y

AU - Berezin, V

AU - Bock, E

AU - Larsen, I K

PY - 2000

Y1 - 2000

N2 - The neural cell adhesion molecule NCAM, a member of the immunoglobulin superfamily, mediates cell-cell recognition and adhesion via a homophilic interaction. NCAM plays a key role during development and regeneration of the nervous system and is involved in synaptic plasticity associated with memory and learning. The 1.85 A crystal structure of the two N-terminal extracellular domains of NCAM reported here provides a structural basis for the homophilic interaction. The molecular packing of the two-domain structure reveals a cross shaped antiparallel dimer, and provides fundamental insight into trans-cellular recognition mediated by NCAM.

AB - The neural cell adhesion molecule NCAM, a member of the immunoglobulin superfamily, mediates cell-cell recognition and adhesion via a homophilic interaction. NCAM plays a key role during development and regeneration of the nervous system and is involved in synaptic plasticity associated with memory and learning. The 1.85 A crystal structure of the two N-terminal extracellular domains of NCAM reported here provides a structural basis for the homophilic interaction. The molecular packing of the two-domain structure reveals a cross shaped antiparallel dimer, and provides fundamental insight into trans-cellular recognition mediated by NCAM.

KW - Amino Acid Sequence

KW - Animals

KW - Binding Sites

KW - Calcium

KW - Cell Adhesion

KW - Crystallography, X-Ray

KW - Dimerization

KW - Heparin

KW - Hydrogen Bonding

KW - Immunoglobulins

KW - Models, Molecular

KW - Molecular Sequence Data

KW - Neural Cell Adhesion Molecules

KW - Protein Binding

KW - Protein Structure, Secondary

KW - Protein Structure, Tertiary

KW - Rats

KW - Sequence Alignment

KW - Structure-Activity Relationship

U2 - 10.1038/75165

DO - 10.1038/75165

M3 - Journal article

C2 - 10802736

SN - 1545-9993

VL - 7

SP - 389

EP - 393

JO - Nature Structural and Molecular Biology

JF - Nature Structural and Molecular Biology

IS - 5

ER -

Structural basis of cell-cell adhesion by NCAM

Abstract

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