Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: Interactions with genotype and equol production

Wendy L. Hall; Katerina Vafeiadou; Jesper Hallund; Susanne Gjedsted Bügel; Manja Reimann; Corinna Koebnick; H. J.Franz Zunft; Marika Ferrari; Francesco Branca; Tony Dadd; Duncan Talbot; Jonathan Powell; Anne Marie Minihane; Aedin Cassidy; Maria Nilsson; Karin Dahlman-Wright; Jan Åke Gustafsson; Christine M. Williams

doi:10.1093/ajcn.83.3.592

Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: Interactions with genotype and equol production

Wendy L. Hall^*, Katerina Vafeiadou, Jesper Hallund, Susanne Gjedsted Bügel, Manja Reimann, Corinna Koebnick, H. J.Franz Zunft, Marika Ferrari, Francesco Branca, Tony Dadd, Duncan Talbot, Jonathan Powell, Anne Marie Minihane, Aedin Cassidy, Maria Nilsson, Karin Dahlman-Wright, Jan Åke Gustafsson, Christine M. Williams

^*Corresponding author af dette arbejde

120 Citationer (Scopus)

Abstract

Background: The hypocholesterolemic effects of soy foods are well established, and it has been suggested that isoflavones are responsible for this effect. However, beneficial effects of isolated isoflavones on lipid biomarkers of cardiovascular disease risk have not yet been shown.

Objective: The objective was to investigate the effects of isolated soy isoflavones on metabolic biomarkers of cardiovascular disease risk, including plasma total, HDL, and LDL cholesterol; triacylglycerols; lipoprotein(a); the percentage of small dense LDL; glucose; nonesterified fatty acids; insulin; and the homeostasis model assessment of insulin resistance. Differences with respect to single nucleotide polymorphisms in selected genes [ie, estrogen receptor α (XbaI and PvuII), estrogen receptor β (AluI), and estrogen receptor β(cx) (Tsp509I), endothelial nitric oxide synthase (Glu298Asp), apolipoprotein E (Apo E2, E3, and E4), cholesteryl ester transfer protein (TaqIB), and leptin receptor (Gln223Arg)] and with respect to equol production were investigated.

Design: Healthy postmenopausal women (n = 117) participated in a randomized, double-blind, placebo-controlled, crossover dietary intervention trial. Isoflavone-enriched (genistein-to-daidzein ratio of 2:1; 50 mg/d) or placebo cereal bars were consumed for 8 wk, with a wash-out period of 8 wk before the crossover.

Results: Isoflavones did not have a significant beneficial effect on plasma concentrations of lipids, glucose, or insulin. A significant difference between the responses of HDL cholesterol to isoflavones and to placebo was found with estrogen receptor β(cx) Tsp509I genotype AA, but not GG or GA.

Conclusions: Isoflavone supplementation, when provided in the form and dose used in this study, had no effect on lipid or other metabolic biomarkers of cardiovascular disease risk in postmenopausal women but may increase HDL cholesterol in an estrogen receptor β gene-polymorphic subgroup.

Originalsprog	Engelsk
Bogserie	American Journal of Clinical Nutrition
Vol/bind	83
Udgave nummer	3
Sider (fra-til)	592-600
Antal sider	9
ISSN	0002-9165
DOI	https://doi.org/10.1093/ajcn.83.3.592
Status	Udgivet - 2006

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Hall, W. L., Vafeiadou, K., Hallund, J., Bügel, S. G., Reimann, M., Koebnick, C., Zunft, H. J. F., Ferrari, M., Branca, F., Dadd, T., Talbot, D., Powell, J., Minihane, A. M., Cassidy, A., Nilsson, M., Dahlman-Wright, K., Gustafsson, J. Å., & Williams, C. M. (2006). Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: Interactions with genotype and equol production. American Journal of Clinical Nutrition, 83(3), 592-600. https://doi.org/10.1093/ajcn.83.3.592

Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women : Interactions with genotype and equol production. / Hall, Wendy L.; Vafeiadou, Katerina; Hallund, Jesper et al.

I: American Journal of Clinical Nutrition, Bind 83, Nr. 3, 2006, s. 592-600.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Hall, WL, Vafeiadou, K, Hallund, J, Bügel, SG, Reimann, M, Koebnick, C, Zunft, HJF, Ferrari, M, Branca, F, Dadd, T, Talbot, D, Powell, J, Minihane, AM, Cassidy, A, Nilsson, M, Dahlman-Wright, K, Gustafsson, JÅ & Williams, CM 2006, 'Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: Interactions with genotype and equol production', American Journal of Clinical Nutrition, bind 83, nr. 3, s. 592-600. https://doi.org/10.1093/ajcn.83.3.592

@article{6ea21b30bc0d42bb9921afd591c3c845,

title = "Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: Interactions with genotype and equol production",

abstract = "Background: The hypocholesterolemic effects of soy foods are well established, and it has been suggested that isoflavones are responsible for this effect. However, beneficial effects of isolated isoflavones on lipid biomarkers of cardiovascular disease risk have not yet been shown. Objective: The objective was to investigate the effects of isolated soy isoflavones on metabolic biomarkers of cardiovascular disease risk, including plasma total, HDL, and LDL cholesterol; triacylglycerols; lipoprotein(a); the percentage of small dense LDL; glucose; nonesterified fatty acids; insulin; and the homeostasis model assessment of insulin resistance. Differences with respect to single nucleotide polymorphisms in selected genes [ie, estrogen receptor α (XbaI and PvuII), estrogen receptor β (AluI), and estrogen receptor β(cx) (Tsp509I), endothelial nitric oxide synthase (Glu298Asp), apolipoprotein E (Apo E2, E3, and E4), cholesteryl ester transfer protein (TaqIB), and leptin receptor (Gln223Arg)] and with respect to equol production were investigated. Design: Healthy postmenopausal women (n = 117) participated in a randomized, double-blind, placebo-controlled, crossover dietary intervention trial. Isoflavone-enriched (genistein-to-daidzein ratio of 2:1; 50 mg/d) or placebo cereal bars were consumed for 8 wk, with a wash-out period of 8 wk before the crossover. Results: Isoflavones did not have a significant beneficial effect on plasma concentrations of lipids, glucose, or insulin. A significant difference between the responses of HDL cholesterol to isoflavones and to placebo was found with estrogen receptor β(cx) Tsp509I genotype AA, but not GG or GA. Conclusions: Isoflavone supplementation, when provided in the form and dose used in this study, had no effect on lipid or other metabolic biomarkers of cardiovascular disease risk in postmenopausal women but may increase HDL cholesterol in an estrogen receptor β gene-polymorphic subgroup.",

keywords = "Cardiovascular disease, Cholesterol, Estrogen receptor, Gene-nutrient interaction, Glucose, Insulin, Isoflavones, Plasma lipids, Postmenopausal women, Soy, Triacylglycerols",

author = "Hall, {Wendy L.} and Katerina Vafeiadou and Jesper Hallund and B{\"u}gel, {Susanne Gjedsted} and Manja Reimann and Corinna Koebnick and Zunft, {H. J.Franz} and Marika Ferrari and Francesco Branca and Tony Dadd and Duncan Talbot and Jonathan Powell and Minihane, {Anne Marie} and Aedin Cassidy and Maria Nilsson and Karin Dahlman-Wright and Gustafsson, {Jan {\AA}ke} and Williams, {Christine M.}",

year = "2006",

doi = "10.1093/ajcn.83.3.592",

language = "English",

volume = "83",

pages = "592--600",

journal = "American Journal of Clinical Nutrition",

issn = "0002-9165",

publisher = "American Society for Nutrition",

number = "3",

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TY - JOUR

T1 - Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women

T2 - Interactions with genotype and equol production

AU - Hall, Wendy L.

AU - Vafeiadou, Katerina

AU - Hallund, Jesper

AU - Bügel, Susanne Gjedsted

AU - Reimann, Manja

AU - Koebnick, Corinna

AU - Zunft, H. J.Franz

AU - Ferrari, Marika

AU - Branca, Francesco

AU - Dadd, Tony

AU - Talbot, Duncan

AU - Powell, Jonathan

AU - Minihane, Anne Marie

AU - Cassidy, Aedin

AU - Nilsson, Maria

AU - Dahlman-Wright, Karin

AU - Gustafsson, Jan Åke

AU - Williams, Christine M.

PY - 2006

Y1 - 2006

N2 - Background: The hypocholesterolemic effects of soy foods are well established, and it has been suggested that isoflavones are responsible for this effect. However, beneficial effects of isolated isoflavones on lipid biomarkers of cardiovascular disease risk have not yet been shown. Objective: The objective was to investigate the effects of isolated soy isoflavones on metabolic biomarkers of cardiovascular disease risk, including plasma total, HDL, and LDL cholesterol; triacylglycerols; lipoprotein(a); the percentage of small dense LDL; glucose; nonesterified fatty acids; insulin; and the homeostasis model assessment of insulin resistance. Differences with respect to single nucleotide polymorphisms in selected genes [ie, estrogen receptor α (XbaI and PvuII), estrogen receptor β (AluI), and estrogen receptor β(cx) (Tsp509I), endothelial nitric oxide synthase (Glu298Asp), apolipoprotein E (Apo E2, E3, and E4), cholesteryl ester transfer protein (TaqIB), and leptin receptor (Gln223Arg)] and with respect to equol production were investigated. Design: Healthy postmenopausal women (n = 117) participated in a randomized, double-blind, placebo-controlled, crossover dietary intervention trial. Isoflavone-enriched (genistein-to-daidzein ratio of 2:1; 50 mg/d) or placebo cereal bars were consumed for 8 wk, with a wash-out period of 8 wk before the crossover. Results: Isoflavones did not have a significant beneficial effect on plasma concentrations of lipids, glucose, or insulin. A significant difference between the responses of HDL cholesterol to isoflavones and to placebo was found with estrogen receptor β(cx) Tsp509I genotype AA, but not GG or GA. Conclusions: Isoflavone supplementation, when provided in the form and dose used in this study, had no effect on lipid or other metabolic biomarkers of cardiovascular disease risk in postmenopausal women but may increase HDL cholesterol in an estrogen receptor β gene-polymorphic subgroup.

AB - Background: The hypocholesterolemic effects of soy foods are well established, and it has been suggested that isoflavones are responsible for this effect. However, beneficial effects of isolated isoflavones on lipid biomarkers of cardiovascular disease risk have not yet been shown. Objective: The objective was to investigate the effects of isolated soy isoflavones on metabolic biomarkers of cardiovascular disease risk, including plasma total, HDL, and LDL cholesterol; triacylglycerols; lipoprotein(a); the percentage of small dense LDL; glucose; nonesterified fatty acids; insulin; and the homeostasis model assessment of insulin resistance. Differences with respect to single nucleotide polymorphisms in selected genes [ie, estrogen receptor α (XbaI and PvuII), estrogen receptor β (AluI), and estrogen receptor β(cx) (Tsp509I), endothelial nitric oxide synthase (Glu298Asp), apolipoprotein E (Apo E2, E3, and E4), cholesteryl ester transfer protein (TaqIB), and leptin receptor (Gln223Arg)] and with respect to equol production were investigated. Design: Healthy postmenopausal women (n = 117) participated in a randomized, double-blind, placebo-controlled, crossover dietary intervention trial. Isoflavone-enriched (genistein-to-daidzein ratio of 2:1; 50 mg/d) or placebo cereal bars were consumed for 8 wk, with a wash-out period of 8 wk before the crossover. Results: Isoflavones did not have a significant beneficial effect on plasma concentrations of lipids, glucose, or insulin. A significant difference between the responses of HDL cholesterol to isoflavones and to placebo was found with estrogen receptor β(cx) Tsp509I genotype AA, but not GG or GA. Conclusions: Isoflavone supplementation, when provided in the form and dose used in this study, had no effect on lipid or other metabolic biomarkers of cardiovascular disease risk in postmenopausal women but may increase HDL cholesterol in an estrogen receptor β gene-polymorphic subgroup.

KW - Cardiovascular disease

KW - Cholesterol

KW - Estrogen receptor

KW - Gene-nutrient interaction

KW - Glucose

KW - Insulin

KW - Isoflavones

KW - Plasma lipids

KW - Postmenopausal women

KW - Soy

KW - Triacylglycerols

U2 - 10.1093/ajcn.83.3.592

DO - 10.1093/ajcn.83.3.592

M3 - Journal article

C2 - 16522905

AN - SCOPUS:33645641438

SN - 0002-9165

VL - 83

SP - 592

EP - 600

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

IS - 3

ER -

Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: Interactions with genotype and equol production

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