Simultaneous hyperpolarized 13C-Pyruvate MRI and 18F-FDG PET (HyperPET) in 10 dogs with cancer

Henrik Gutte Borgwardt; Adam Espe Hansen; Majbrit M. E. Larsen; Sofie Rahbek; Sarah T. Henriksen; Helle Hjorth Johannesen; Jan Henrik Ardenkjær-Larsen; Annemarie Thuri Kristensen; Liselotte Højgaard; Andreas Kjær

doi:10.2967/jnumed.115.156364

Simultaneous hyperpolarized ¹³C-Pyruvate MRI and ¹⁸F-FDG PET (HyperPET) in 10 dogs with cancer

Henrik Gutte Borgwardt, Adam Espe Hansen, Majbrit M. E. Larsen, Sofie Rahbek, Sarah T. Henriksen, Helle Hjorth Johannesen, Jan Henrik Ardenkjær-Larsen, Annemarie Thuri Kristensen, Liselotte Højgaard, Andreas Kjær

29 Citationer (Scopus)

Abstract

With the introduction of combined PET/MR spectroscopic (MRS) imaging, it is now possible to directly and indirectly image the Warburg effect with hyperpolarized (13)C-pyruvate and (18)F-FDG PET imaging, respectively, via a technique we have named hyperPET. The main purpose of this present study was to establish a practical workflow for performing (18)F-FDG PET and hyperpolarized (13)C-pyruvate MRS imaging simultaneously for tumor tissue characterization and on a larger scale test its feasibility. In addition, we evaluated the correlation between (18)F-FDG uptake and (13)C-lactate production.

METHODS: Ten dogs with biopsy-verified spontaneous malignant tumors were included for imaging. All dogs underwent a protocol of simultaneous (18)F-FDG PET, anatomic MR, and hyperpolarized dynamic nuclear polarization with (13)C-pyruvate imaging. The data were acquired using a combined clinical PET/MR imaging scanner.

RESULTS: We found that combined (18)F-FDG PET and (13)C-pyruvate MRS imaging was possible in a single session of approximately 2 h. A continuous workflow was obtained with the injection of (18)F-FDG when the dogs was placed in the PET/MR scanner. (13)C-MRS dynamic acquisition demonstrated in an axial slab increased (13)C-lactate production in 9 of 10 dogs. For the 9 dogs, the (13)C-lactate was detected after a mean of 25 s (range, 17-33 s), with a mean to peak of (13)C-lactate at 49 s (range, 40-62 s). (13)C-pyruvate could be detected on average after 13 s (range, 5-26 s) and peaked on average after 25 s (range, 13-42 s). We noticed concordance of (18)F-FDG uptake and production of (13)C-lactate in most, but not all, axial slices.

CONCLUSION: In this study, we have shown in a series of dogs with cancer that hyperPET can easily be performed within 2 h. We showed mostly correspondence between (13)C-lactate production and (18)F-FDG uptake and expect the combined modalities to reveal additional metabolic information to improve prognostic value and improve response monitoring.

Originalsprog	Engelsk
Tidsskrift	Journal of Nuclear Medicine
Vol/bind	56
Udgave nummer	11
Sider (fra-til)	1786-92
Antal sider	7
ISSN	0161-5505
DOI	https://doi.org/10.2967/jnumed.115.156364
Status	Udgivet - 1 nov. 2015

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Citationsformater

@article{13602fcb242941aba54f840d1dde46b0,

title = "Simultaneous hyperpolarized 13C-Pyruvate MRI and 18F-FDG PET (HyperPET) in 10 dogs with cancer",

abstract = "With the introduction of combined PET/MR spectroscopic (MRS) imaging, it is now possible to directly and indirectly image the Warburg effect with hyperpolarized (13)C-pyruvate and (18)F-FDG PET imaging, respectively, via a technique we have named hyperPET. The main purpose of this present study was to establish a practical workflow for performing (18)F-FDG PET and hyperpolarized (13)C-pyruvate MRS imaging simultaneously for tumor tissue characterization and on a larger scale test its feasibility. In addition, we evaluated the correlation between (18)F-FDG uptake and (13)C-lactate production.METHODS: Ten dogs with biopsy-verified spontaneous malignant tumors were included for imaging. All dogs underwent a protocol of simultaneous (18)F-FDG PET, anatomic MR, and hyperpolarized dynamic nuclear polarization with (13)C-pyruvate imaging. The data were acquired using a combined clinical PET/MR imaging scanner.RESULTS: We found that combined (18)F-FDG PET and (13)C-pyruvate MRS imaging was possible in a single session of approximately 2 h. A continuous workflow was obtained with the injection of (18)F-FDG when the dogs was placed in the PET/MR scanner. (13)C-MRS dynamic acquisition demonstrated in an axial slab increased (13)C-lactate production in 9 of 10 dogs. For the 9 dogs, the (13)C-lactate was detected after a mean of 25 s (range, 17-33 s), with a mean to peak of (13)C-lactate at 49 s (range, 40-62 s). (13)C-pyruvate could be detected on average after 13 s (range, 5-26 s) and peaked on average after 25 s (range, 13-42 s). We noticed concordance of (18)F-FDG uptake and production of (13)C-lactate in most, but not all, axial slices.CONCLUSION: In this study, we have shown in a series of dogs with cancer that hyperPET can easily be performed within 2 h. We showed mostly correspondence between (13)C-lactate production and (18)F-FDG uptake and expect the combined modalities to reveal additional metabolic information to improve prognostic value and improve response monitoring.",

keywords = "cancer, dynamic nuclear polarization, hyperpolarized, 13C-pyruvate, MR, 18F-FDG PET, PET/MR, molecular imaging",

author = "Borgwardt, {Henrik Gutte} and Hansen, {Adam Espe} and Larsen, {Majbrit M. E.} and Sofie Rahbek and Henriksen, {Sarah T.} and Johannesen, {Helle Hjorth} and Ardenkj{\ae}r-Larsen, {Jan Henrik} and Kristensen, {Annemarie Thuri} and Liselotte H{\o}jgaard and Andreas Kj{\ae}r",

note = "{\textcopyright} 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.",

year = "2015",

month = nov,

day = "1",

doi = "10.2967/jnumed.115.156364",

language = "English",

volume = "56",

pages = "1786--92",

journal = "Journal of Nuclear Medicine",

issn = "0161-5505",

publisher = "Society of Nuclear Medicine",

number = "11",

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TY - JOUR

T1 - Simultaneous hyperpolarized 13C-Pyruvate MRI and 18F-FDG PET (HyperPET) in 10 dogs with cancer

AU - Borgwardt, Henrik Gutte

AU - Hansen, Adam Espe

AU - Larsen, Majbrit M. E.

AU - Rahbek, Sofie

AU - Henriksen, Sarah T.

AU - Johannesen, Helle Hjorth

AU - Ardenkjær-Larsen, Jan Henrik

AU - Kristensen, Annemarie Thuri

AU - Højgaard, Liselotte

AU - Kjær, Andreas

PY - 2015/11/1

Y1 - 2015/11/1

N2 - With the introduction of combined PET/MR spectroscopic (MRS) imaging, it is now possible to directly and indirectly image the Warburg effect with hyperpolarized (13)C-pyruvate and (18)F-FDG PET imaging, respectively, via a technique we have named hyperPET. The main purpose of this present study was to establish a practical workflow for performing (18)F-FDG PET and hyperpolarized (13)C-pyruvate MRS imaging simultaneously for tumor tissue characterization and on a larger scale test its feasibility. In addition, we evaluated the correlation between (18)F-FDG uptake and (13)C-lactate production.METHODS: Ten dogs with biopsy-verified spontaneous malignant tumors were included for imaging. All dogs underwent a protocol of simultaneous (18)F-FDG PET, anatomic MR, and hyperpolarized dynamic nuclear polarization with (13)C-pyruvate imaging. The data were acquired using a combined clinical PET/MR imaging scanner.RESULTS: We found that combined (18)F-FDG PET and (13)C-pyruvate MRS imaging was possible in a single session of approximately 2 h. A continuous workflow was obtained with the injection of (18)F-FDG when the dogs was placed in the PET/MR scanner. (13)C-MRS dynamic acquisition demonstrated in an axial slab increased (13)C-lactate production in 9 of 10 dogs. For the 9 dogs, the (13)C-lactate was detected after a mean of 25 s (range, 17-33 s), with a mean to peak of (13)C-lactate at 49 s (range, 40-62 s). (13)C-pyruvate could be detected on average after 13 s (range, 5-26 s) and peaked on average after 25 s (range, 13-42 s). We noticed concordance of (18)F-FDG uptake and production of (13)C-lactate in most, but not all, axial slices.CONCLUSION: In this study, we have shown in a series of dogs with cancer that hyperPET can easily be performed within 2 h. We showed mostly correspondence between (13)C-lactate production and (18)F-FDG uptake and expect the combined modalities to reveal additional metabolic information to improve prognostic value and improve response monitoring.

AB - With the introduction of combined PET/MR spectroscopic (MRS) imaging, it is now possible to directly and indirectly image the Warburg effect with hyperpolarized (13)C-pyruvate and (18)F-FDG PET imaging, respectively, via a technique we have named hyperPET. The main purpose of this present study was to establish a practical workflow for performing (18)F-FDG PET and hyperpolarized (13)C-pyruvate MRS imaging simultaneously for tumor tissue characterization and on a larger scale test its feasibility. In addition, we evaluated the correlation between (18)F-FDG uptake and (13)C-lactate production.METHODS: Ten dogs with biopsy-verified spontaneous malignant tumors were included for imaging. All dogs underwent a protocol of simultaneous (18)F-FDG PET, anatomic MR, and hyperpolarized dynamic nuclear polarization with (13)C-pyruvate imaging. The data were acquired using a combined clinical PET/MR imaging scanner.RESULTS: We found that combined (18)F-FDG PET and (13)C-pyruvate MRS imaging was possible in a single session of approximately 2 h. A continuous workflow was obtained with the injection of (18)F-FDG when the dogs was placed in the PET/MR scanner. (13)C-MRS dynamic acquisition demonstrated in an axial slab increased (13)C-lactate production in 9 of 10 dogs. For the 9 dogs, the (13)C-lactate was detected after a mean of 25 s (range, 17-33 s), with a mean to peak of (13)C-lactate at 49 s (range, 40-62 s). (13)C-pyruvate could be detected on average after 13 s (range, 5-26 s) and peaked on average after 25 s (range, 13-42 s). We noticed concordance of (18)F-FDG uptake and production of (13)C-lactate in most, but not all, axial slices.CONCLUSION: In this study, we have shown in a series of dogs with cancer that hyperPET can easily be performed within 2 h. We showed mostly correspondence between (13)C-lactate production and (18)F-FDG uptake and expect the combined modalities to reveal additional metabolic information to improve prognostic value and improve response monitoring.

KW - cancer

KW - dynamic nuclear polarization

KW - hyperpolarized

KW - 13C-pyruvate

KW - MR

KW - 18F-FDG PET

KW - PET/MR

KW - molecular imaging

U2 - 10.2967/jnumed.115.156364

DO - 10.2967/jnumed.115.156364

M3 - Journal article

C2 - 26338899

SN - 0161-5505

VL - 56

SP - 1786

EP - 1792

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

IS - 11

ER -