Similar incretin secretion in obese and non-obese Japanese subjects with type 2 diabetes

TY - JOUR

T1 - Similar incretin secretion in obese and non-obese Japanese subjects with type 2 diabetes

AU - Kozawa, Junji

AU - Okita, Kohei

AU - Imagawa, Akihisa

AU - Iwahashi, Hiromi

AU - Holst, Jens Juul

AU - Yamagata, Kazuya

AU - Shimomura, Iichiro

N1 - 2010 Elsevier Inc. All rights reserved.

PY - 2010/3/12

Y1 - 2010/3/12

N2 - Incretin secretion and effect on insulin secretion are not fully understood in patients with type 2 diabetes. We investigated incretin and insulin secretion after meal intake in obese and non-obese Japanese patients with type 2 diabetes compared to non-diabetic subjects. Nine patients with type 2 diabetes and 5 non-diabetic subjects were recruited for this study. Five diabetic patients were obese (BMI ≥ 25) and 4 patients were non-obese (BMI < 25). In response to a mixed meal test, the levels of immunoreactive insulin during 15-90 min and C-peptide during 0-180 min in non-obese patients were significantly lower than those in obese patients. Total GLP-1 and active GIP levels showed no significant difference between obese and non-obese patients throughout the meal tolerance test. In addition, there were no significant differences between diabetic patients and non-diabetic subjects. In conclusion, incretin secretion does not differ between Japanese obese and non-obese patients with type 2 diabetes and non-diabetic subjects.

AB - Incretin secretion and effect on insulin secretion are not fully understood in patients with type 2 diabetes. We investigated incretin and insulin secretion after meal intake in obese and non-obese Japanese patients with type 2 diabetes compared to non-diabetic subjects. Nine patients with type 2 diabetes and 5 non-diabetic subjects were recruited for this study. Five diabetic patients were obese (BMI ≥ 25) and 4 patients were non-obese (BMI < 25). In response to a mixed meal test, the levels of immunoreactive insulin during 15-90 min and C-peptide during 0-180 min in non-obese patients were significantly lower than those in obese patients. Total GLP-1 and active GIP levels showed no significant difference between obese and non-obese patients throughout the meal tolerance test. In addition, there were no significant differences between diabetic patients and non-diabetic subjects. In conclusion, incretin secretion does not differ between Japanese obese and non-obese patients with type 2 diabetes and non-diabetic subjects.

KW - Body Mass Index

KW - C-Peptide

KW - Diabetes Mellitus, Type 2

KW - Glucagon-Like Peptide 1

KW - Humans

KW - Incretins

KW - Insulin

KW - Middle Aged

KW - Obesity

U2 - 10.1016/j.bbrc.2010.01.134

DO - 10.1016/j.bbrc.2010.01.134

M3 - Journal article

C2 - 20138827

SN - 0006-291X

VL - 393

SP - 410

EP - 413

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 3

ER -