Abstract
Incretin secretion and effect on insulin secretion are not fully understood in patients with type 2 diabetes. We investigated incretin and insulin secretion after meal intake in obese and non-obese Japanese patients with type 2 diabetes compared to non-diabetic subjects. Nine patients with type 2 diabetes and 5 non-diabetic subjects were recruited for this study. Five diabetic patients were obese (BMI ≥ 25) and 4 patients were non-obese (BMI < 25). In response to a mixed meal test, the levels of immunoreactive insulin during 15-90 min and C-peptide during 0-180 min in non-obese patients were significantly lower than those in obese patients. Total GLP-1 and active GIP levels showed no significant difference between obese and non-obese patients throughout the meal tolerance test. In addition, there were no significant differences between diabetic patients and non-diabetic subjects. In conclusion, incretin secretion does not differ between Japanese obese and non-obese patients with type 2 diabetes and non-diabetic subjects.
| Original language | English |
|---|---|
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 393 |
| Issue number | 3 |
| Pages (from-to) | 410-3 |
| Number of pages | 4 |
| ISSN | 0006-291X |
| DOIs | |
| Publication status | Published - 12 Mar 2010 |
Keywords
- Body Mass Index
- C-Peptide
- Diabetes Mellitus, Type 2
- Glucagon-Like Peptide 1
- Humans
- Incretins
- Insulin
- Middle Aged
- Obesity
