Significance of myofibroblasts in oral squamous cell carcinoma

Christenze Thode; Trine G. Jørgensen; Erik Dabelsteen; Ian Mackenzie; Sally Dabelsteen

doi:10.1111/j.1600-0714.2010.00999.x

Significance of myofibroblasts in oral squamous cell carcinoma

Christenze Thode, Trine G. Jørgensen, Erik Dabelsteen, Ian Mackenzie, Sally Dabelsteen

45 Citationer (Scopus)

Abstract

It is now recognized that the tumor microenvironment makes significant contribution to tumor progression. Activated fibroblast endothelial cells, inflammatory cells, and various extra cellular matrix components are parts of this microenvironment. Most of the activated fibroblasts are α-smooth muscle actin-positive myofibroblast that often represent the majority of tumor stromal cells. Their production of growth factors chemokines and extracellular matrix facilitates tumor growth. Myofibroblast have been demonstrated in close to 50% of oral squamous cell carcinomas. In this review, we highlight the histological distribution of myofibroblast in oral squamous cell and the myofibroblast relation to tumor growth on prognosis.

Originalsprog	Engelsk
Tidsskrift	Journal of Oral Pathology & Medicine
Vol/bind	40
Udgave nummer	3
Sider (fra-til)	201-7
Antal sider	7
ISSN	0904-2512
DOI	https://doi.org/10.1111/j.1600-0714.2010.00999.x
Status	Udgivet - 1 mar. 2011

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10.1111/j.1600-0714.2010.00999.x

Citationsformater

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title = "Significance of myofibroblasts in oral squamous cell carcinoma",

abstract = "It is now recognized that the tumor microenvironment makes significant contribution to tumor progression. Activated fibroblast endothelial cells, inflammatory cells, and various extra cellular matrix components are parts of this microenvironment. Most of the activated fibroblasts are α-smooth muscle actin-positive myofibroblast that often represent the majority of tumor stromal cells. Their production of growth factors chemokines and extracellular matrix facilitates tumor growth. Myofibroblast have been demonstrated in close to 50% of oral squamous cell carcinomas. In this review, we highlight the histological distribution of myofibroblast in oral squamous cell and the myofibroblast relation to tumor growth on prognosis.",

keywords = "Actins, Carcinoma, Squamous Cell, Chemokines, Disease Progression, Endothelial Cells, Extracellular Matrix Proteins, Fibroblasts, Humans, Mouth Neoplasms, Myofibroblasts, Prognosis, Stromal Cells, Tumor Microenvironment",

author = "Christenze Thode and J{\o}rgensen, {Trine G.} and Erik Dabelsteen and Ian Mackenzie and Sally Dabelsteen",

note = "{\textcopyright} 2011 John Wiley & Sons A/S.",

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T1 - Significance of myofibroblasts in oral squamous cell carcinoma

AU - Thode, Christenze

AU - Jørgensen, Trine G.

AU - Dabelsteen, Erik

AU - Mackenzie, Ian

AU - Dabelsteen, Sally

PY - 2011/3/1

Y1 - 2011/3/1

N2 - It is now recognized that the tumor microenvironment makes significant contribution to tumor progression. Activated fibroblast endothelial cells, inflammatory cells, and various extra cellular matrix components are parts of this microenvironment. Most of the activated fibroblasts are α-smooth muscle actin-positive myofibroblast that often represent the majority of tumor stromal cells. Their production of growth factors chemokines and extracellular matrix facilitates tumor growth. Myofibroblast have been demonstrated in close to 50% of oral squamous cell carcinomas. In this review, we highlight the histological distribution of myofibroblast in oral squamous cell and the myofibroblast relation to tumor growth on prognosis.

AB - It is now recognized that the tumor microenvironment makes significant contribution to tumor progression. Activated fibroblast endothelial cells, inflammatory cells, and various extra cellular matrix components are parts of this microenvironment. Most of the activated fibroblasts are α-smooth muscle actin-positive myofibroblast that often represent the majority of tumor stromal cells. Their production of growth factors chemokines and extracellular matrix facilitates tumor growth. Myofibroblast have been demonstrated in close to 50% of oral squamous cell carcinomas. In this review, we highlight the histological distribution of myofibroblast in oral squamous cell and the myofibroblast relation to tumor growth on prognosis.

KW - Actins

KW - Carcinoma, Squamous Cell

KW - Chemokines

KW - Disease Progression

KW - Endothelial Cells

KW - Extracellular Matrix Proteins

KW - Fibroblasts

KW - Humans

KW - Mouth Neoplasms

KW - Myofibroblasts

KW - Prognosis

KW - Stromal Cells

KW - Tumor Microenvironment

U2 - 10.1111/j.1600-0714.2010.00999.x

DO - 10.1111/j.1600-0714.2010.00999.x

M3 - Journal article

C2 - 21342271

SN - 0904-2512

VL - 40

SP - 201

EP - 207

JO - Journal of Oral Pathology & Medicine

JF - Journal of Oral Pathology & Medicine

IS - 3

ER -

Significance of myofibroblasts in oral squamous cell carcinoma

Abstract

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