Serum Protein Profile Study of Clinical Samples Using High Performance Liquid Chromatography-Laser Induced Fluorescence: Case of Cervical and Oral Cancers

TY - GEN

T1 - Serum Protein Profile Study of Clinical Samples Using High Performance Liquid Chromatography-Laser Induced Fluorescence

T2 - SPIE-2009-Imaging, Manipulation of Biomolecules, Cells, and Tissues VII

AU - Karemore, Gopal Raghunath

AU - Ukendt, Sujatha

AU - Rai, Lavanya

AU - Pai, Keerhilatha

AU - Kartha, V.B

AU - C, Santhosh

PY - 2009

Y1 - 2009

N2 - The serum protein profiles of normal subjects, patients diagnosed with cervical cancer, and oral cancer were recorded using High Performance Liquid Chromatography combined with Laser Induced Fluorescence detection (HPLC-LIF). Serum protein profiles of the above three classes were tested for establishing the ability of HPLC-LIF protein profiling technique for discrimination, using hard clustering and Fuzzy clustering methods. The clustering algorithms have quite successfully classified the profiles as belonging to normal, cancer of cervix, and oral cancer conditions.

AB - The serum protein profiles of normal subjects, patients diagnosed with cervical cancer, and oral cancer were recorded using High Performance Liquid Chromatography combined with Laser Induced Fluorescence detection (HPLC-LIF). Serum protein profiles of the above three classes were tested for establishing the ability of HPLC-LIF protein profiling technique for discrimination, using hard clustering and Fuzzy clustering methods. The clustering algorithms have quite successfully classified the profiles as belonging to normal, cancer of cervix, and oral cancer conditions.

U2 - 10.1117/12.809930

DO - 10.1117/12.809930

M3 - Article in proceedings

VL - 7182

SP - 71820J-71820J-9

BT - Proceedings of the SPIE

Y2 - 26 January 2009 through 28 January 2009

ER -