Role of calcium activated potassium channels in atrial fibrillation pathophysiology and therapy

Jonas G. Diness; Bo H. Bentzen; Ulrik S. Sørensen; Morten Grunnet

doi:10.1097/FJC.0000000000000249

Role of calcium activated potassium channels in atrial fibrillation pathophysiology and therapy

Jonas G. Diness, Bo H. Bentzen, Ulrik S. Sørensen, Morten Grunnet

26 Citationer (Scopus)

Abstract

Small-conductance Ca²⁺-activated potassium (SK) channels are relative newcomers within the field of cardiac electrophysiology. In recent years, an increased focus has been given to these channels because they might constitute a relatively atrial-selective target. This review will give a general introduction to SK channels followed by their proposed function in the heart under normal and pathophysiological conditions. It is revealed how antiarrhythmic effects can be obtained by SK channel inhibition in a number of species in situations of atrial fibrillation. On the contrary, the beneficial effects of SK channel inhibition in situations of heart failure are questionable and still needs investigation. The understanding of cardiac SK channels is rapidly increasing these years, and it is hoped that this will clarify whether SK channel inhibition has potential as a new anti-atrial fibrillation principle.

Originalsprog	Engelsk
Tidsskrift	Journal of Cardiovascular Pharmacology
Vol/bind	66
Udgave nummer	5
Sider (fra-til)	441-448
Antal sider	8
ISSN	0160-2446
DOI	https://doi.org/10.1097/FJC.0000000000000249
Status	Udgivet - 1 nov. 2015

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abstract = "Small-conductance Ca2+-activated potassium (SK) channels are relative newcomers within the field of cardiac electrophysiology. In recent years, an increased focus has been given to these channels because they might constitute a relatively atrial-selective target. This review will give a general introduction to SK channels followed by their proposed function in the heart under normal and pathophysiological conditions. It is revealed how antiarrhythmic effects can be obtained by SK channel inhibition in a number of species in situations of atrial fibrillation. On the contrary, the beneficial effects of SK channel inhibition in situations of heart failure are questionable and still needs investigation. The understanding of cardiac SK channels is rapidly increasing these years, and it is hoped that this will clarify whether SK channel inhibition has potential as a new anti-atrial fibrillation principle.",

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AU - Diness, Jonas G.

AU - Bentzen, Bo H.

AU - S. Sørensen, Ulrik

AU - Grunnet, Morten

PY - 2015/11/1

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N2 - Small-conductance Ca2+-activated potassium (SK) channels are relative newcomers within the field of cardiac electrophysiology. In recent years, an increased focus has been given to these channels because they might constitute a relatively atrial-selective target. This review will give a general introduction to SK channels followed by their proposed function in the heart under normal and pathophysiological conditions. It is revealed how antiarrhythmic effects can be obtained by SK channel inhibition in a number of species in situations of atrial fibrillation. On the contrary, the beneficial effects of SK channel inhibition in situations of heart failure are questionable and still needs investigation. The understanding of cardiac SK channels is rapidly increasing these years, and it is hoped that this will clarify whether SK channel inhibition has potential as a new anti-atrial fibrillation principle.

AB - Small-conductance Ca2+-activated potassium (SK) channels are relative newcomers within the field of cardiac electrophysiology. In recent years, an increased focus has been given to these channels because they might constitute a relatively atrial-selective target. This review will give a general introduction to SK channels followed by their proposed function in the heart under normal and pathophysiological conditions. It is revealed how antiarrhythmic effects can be obtained by SK channel inhibition in a number of species in situations of atrial fibrillation. On the contrary, the beneficial effects of SK channel inhibition in situations of heart failure are questionable and still needs investigation. The understanding of cardiac SK channels is rapidly increasing these years, and it is hoped that this will clarify whether SK channel inhibition has potential as a new anti-atrial fibrillation principle.

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JO - Journal of Cardiovascular Pharmacology

JF - Journal of Cardiovascular Pharmacology

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Role of calcium activated potassium channels in atrial fibrillation pathophysiology and therapy

Abstract

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