Resistance training and aerobic training improve muscle strength and aerobic capacity in chronic inflammatory demyelinating polyneuropathy

Lars H Markvardsen; Kristian Overgaard; Karen Heje; Søren H Sindrup; Ingelise Christiansen; John Vissing; Henning Andersen

doi:10.1002/mus.25652

Resistance training and aerobic training improve muscle strength and aerobic capacity in chronic inflammatory demyelinating polyneuropathy

Lars H Markvardsen, Kristian Overgaard, Karen Heje, Søren H Sindrup, Ingelise Christiansen, John Vissing, Henning Andersen

Institut for Klinisk Medicin

9 Citationer (Scopus)

Abstract

INTRODUCTION: We investigated the effects of aerobic and resistance exercise in patients with chronic inflammatory demyelinating polyneuropathy (CIDP).

METHODS: Eighteen CIDP patients treated with subcutaneous immunoglobulin performed 12 weeks of aerobic exercise and 12 weeks of resistance exercise after a run-in period of 12 weeks without exercise. Three times weekly the participants performed aerobic exercise on an ergometer bike or resistance exercise with unilateral training of knee and elbow flexion/extension. Primary outcomes were maximal oxygen consumption velocity (VO2 -max) and maximal combined isokinetic muscle strength (cIKS) of knee and elbow flexion/extension.

RESULTS: VO2 -max and muscle strength were unchanged during run-in (-4.9% ± 10.3%, P = 0.80 and -3.7% ± 10.1%, P = 0.17, respectively). Aerobic exercise increased VO2 -max by 11.0% ± 14.7% (P = 0.02). Resistance exercise resulted in an increase of 13.8% ± 16.0% (P = 0.0004) in cIKS.

DISCUSSION: Aerobic exercise training and resistance exercise training improve fitness and strength in CIDP patients. Muscle Nerve 57: 70-76, 2018.

Originalsprog	Engelsk
Tidsskrift	Muscle & Nerve
Vol/bind	57
Udgave nummer	1
Sider (fra-til)	70-76
ISSN	0148-639X
DOI	https://doi.org/10.1002/mus.25652
Status	Udgivet - jan. 2018

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10.1002/mus.25652

Citationsformater

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title = "Resistance training and aerobic training improve muscle strength and aerobic capacity in chronic inflammatory demyelinating polyneuropathy",

abstract = "INTRODUCTION: We investigated the effects of aerobic and resistance exercise in patients with chronic inflammatory demyelinating polyneuropathy (CIDP).METHODS: Eighteen CIDP patients treated with subcutaneous immunoglobulin performed 12 weeks of aerobic exercise and 12 weeks of resistance exercise after a run-in period of 12 weeks without exercise. Three times weekly the participants performed aerobic exercise on an ergometer bike or resistance exercise with unilateral training of knee and elbow flexion/extension. Primary outcomes were maximal oxygen consumption velocity (VO2 -max) and maximal combined isokinetic muscle strength (cIKS) of knee and elbow flexion/extension.RESULTS: VO2 -max and muscle strength were unchanged during run-in (-4.9% ± 10.3%, P = 0.80 and -3.7% ± 10.1%, P = 0.17, respectively). Aerobic exercise increased VO2 -max by 11.0% ± 14.7% (P = 0.02). Resistance exercise resulted in an increase of 13.8% ± 16.0% (P = 0.0004) in cIKS.DISCUSSION: Aerobic exercise training and resistance exercise training improve fitness and strength in CIDP patients. Muscle Nerve 57: 70-76, 2018.",

keywords = "Anaerobic Threshold, Bicycling, Elbow/physiopathology, Exercise, Exercise Therapy/methods, Female, Humans, Immunization, Passive, Knee/physiopathology, Male, Middle Aged, Muscle Strength, Oxygen Consumption/physiology, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/physiopathology, Quality of Life, Resistance Training, Treatment Outcome",

author = "Markvardsen, {Lars H} and Kristian Overgaard and Karen Heje and Sindrup, {S{\o}ren H} and Ingelise Christiansen and John Vissing and Henning Andersen",

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T1 - Resistance training and aerobic training improve muscle strength and aerobic capacity in chronic inflammatory demyelinating polyneuropathy

AU - Markvardsen, Lars H

AU - Overgaard, Kristian

AU - Heje, Karen

AU - Sindrup, Søren H

AU - Christiansen, Ingelise

AU - Vissing, John

AU - Andersen, Henning

PY - 2018/1

Y1 - 2018/1

N2 - INTRODUCTION: We investigated the effects of aerobic and resistance exercise in patients with chronic inflammatory demyelinating polyneuropathy (CIDP).METHODS: Eighteen CIDP patients treated with subcutaneous immunoglobulin performed 12 weeks of aerobic exercise and 12 weeks of resistance exercise after a run-in period of 12 weeks without exercise. Three times weekly the participants performed aerobic exercise on an ergometer bike or resistance exercise with unilateral training of knee and elbow flexion/extension. Primary outcomes were maximal oxygen consumption velocity (VO2 -max) and maximal combined isokinetic muscle strength (cIKS) of knee and elbow flexion/extension.RESULTS: VO2 -max and muscle strength were unchanged during run-in (-4.9% ± 10.3%, P = 0.80 and -3.7% ± 10.1%, P = 0.17, respectively). Aerobic exercise increased VO2 -max by 11.0% ± 14.7% (P = 0.02). Resistance exercise resulted in an increase of 13.8% ± 16.0% (P = 0.0004) in cIKS.DISCUSSION: Aerobic exercise training and resistance exercise training improve fitness and strength in CIDP patients. Muscle Nerve 57: 70-76, 2018.

AB - INTRODUCTION: We investigated the effects of aerobic and resistance exercise in patients with chronic inflammatory demyelinating polyneuropathy (CIDP).METHODS: Eighteen CIDP patients treated with subcutaneous immunoglobulin performed 12 weeks of aerobic exercise and 12 weeks of resistance exercise after a run-in period of 12 weeks without exercise. Three times weekly the participants performed aerobic exercise on an ergometer bike or resistance exercise with unilateral training of knee and elbow flexion/extension. Primary outcomes were maximal oxygen consumption velocity (VO2 -max) and maximal combined isokinetic muscle strength (cIKS) of knee and elbow flexion/extension.RESULTS: VO2 -max and muscle strength were unchanged during run-in (-4.9% ± 10.3%, P = 0.80 and -3.7% ± 10.1%, P = 0.17, respectively). Aerobic exercise increased VO2 -max by 11.0% ± 14.7% (P = 0.02). Resistance exercise resulted in an increase of 13.8% ± 16.0% (P = 0.0004) in cIKS.DISCUSSION: Aerobic exercise training and resistance exercise training improve fitness and strength in CIDP patients. Muscle Nerve 57: 70-76, 2018.

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KW - Elbow/physiopathology

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KW - Exercise Therapy/methods

KW - Female

KW - Humans

KW - Immunization, Passive

KW - Knee/physiopathology

KW - Male

KW - Middle Aged

KW - Muscle Strength

KW - Oxygen Consumption/physiology

KW - Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/physiopathology

KW - Quality of Life

KW - Resistance Training

KW - Treatment Outcome

U2 - 10.1002/mus.25652

DO - 10.1002/mus.25652

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SN - 0148-639X

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JO - Muscle & Nerve

JF - Muscle & Nerve

IS - 1

ER -

Resistance training and aerobic training improve muscle strength and aerobic capacity in chronic inflammatory demyelinating polyneuropathy

Abstract

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