Regulation of homologous recombination at telomeres in budding yeast

TY - JOUR

T1 - Regulation of homologous recombination at telomeres in budding yeast

AU - Eckert-Boulet, Nadine

AU - Lisby, Michael

N1 - Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

PY - 2010/9/10

Y1 - 2010/9/10

N2 - Homologous recombination is suppressed at normal length telomere sequences. In contrast, telomere recombination is allowed when telomeres erode in the absence of telomerase activity or as a consequence of nucleolytic degradation or incomplete replication. Here, we review the mechanisms that contribute to regulating mitotic homologous recombination at telomeres and the role of these mechanisms in signalling short telomeres in the budding yeast Saccharomyces cerevisiae.

AB - Homologous recombination is suppressed at normal length telomere sequences. In contrast, telomere recombination is allowed when telomeres erode in the absence of telomerase activity or as a consequence of nucleolytic degradation or incomplete replication. Here, we review the mechanisms that contribute to regulating mitotic homologous recombination at telomeres and the role of these mechanisms in signalling short telomeres in the budding yeast Saccharomyces cerevisiae.

KW - Cell Cycle Proteins

KW - Chromosomes, Fungal

KW - Conserved Sequence

KW - DNA Damage

KW - DNA Repair

KW - DNA, Fungal

KW - DNA-Directed DNA Polymerase

KW - Expressed Sequence Tags

KW - Recombination, Genetic

KW - Saccharomycetales

KW - Telomere

U2 - 10.1016/j.febslet.2010.05.037

DO - 10.1016/j.febslet.2010.05.037

M3 - Journal article

C2 - 20580716

SN - 0014-5793

VL - 584

SP - 3696

EP - 3702

JO - F E B S Letters

JF - F E B S Letters

IS - 17

ER -