TY - JOUR
T1 - Reference values of electrocardiogram repolarization variables in a healthy population
AU - Haarmark, Christian
AU - Graff, Claus
AU - Andersen, Mads P
AU - Hardahl, Thomas Bork
AU - Struijk, Johannes J.
AU - Toft, Egon
AU - Xue, Joel
AU - Rowlandson, Gordon I
AU - Hansen, Peter R
AU - Kanters, Jørgen K.
PY - 2010/1
Y1 - 2010/1
N2 - Introduction: Reference values for T-wave morphology analysis and evaluation of the relationship with age, sex, and heart rate are lacking in the literature. In this study, we characterized T-wave morphology in a large sample of healthy individuals. Method: A total of 1081 healthy subjects (83% men; range, 17-81 years) were included. T-wave morphology variables describing the duration, area, slopes, amplitude, and distribution were calculated using 10-second digital electrocardiogram recordings. Multivariate regression was used to test for dependence of T-wave variables with the subject age, sex, and heart rate. Results: Lead V5 (men vs women) T-wave variables were as follows: amplitude, 444 versus 317 μV; area, 48.4 versus 33.2 ms * mV; Tpeak-Tend interval, 94 versus 92 milliseconds; maximal descending slope, -5.15 versus -3.69 μV/ms; skewness, -0.24 versus -0.22; and kurtosis, -0.36 versus -0.35. Tpeak-Tend interval, skewness, and kurtosis were independent of age, sex, and heart rate (r2 < 0.05), whereas Bazett-corrected QT-interval was more dependent (r2 = 0.40). Conclusion: A selection of T-wave morphology variables is found to be clinically independent of age, sex, and heart rate, including Tpeak-Tend interval, skewness, and kurtosis.
AB - Introduction: Reference values for T-wave morphology analysis and evaluation of the relationship with age, sex, and heart rate are lacking in the literature. In this study, we characterized T-wave morphology in a large sample of healthy individuals. Method: A total of 1081 healthy subjects (83% men; range, 17-81 years) were included. T-wave morphology variables describing the duration, area, slopes, amplitude, and distribution were calculated using 10-second digital electrocardiogram recordings. Multivariate regression was used to test for dependence of T-wave variables with the subject age, sex, and heart rate. Results: Lead V5 (men vs women) T-wave variables were as follows: amplitude, 444 versus 317 μV; area, 48.4 versus 33.2 ms * mV; Tpeak-Tend interval, 94 versus 92 milliseconds; maximal descending slope, -5.15 versus -3.69 μV/ms; skewness, -0.24 versus -0.22; and kurtosis, -0.36 versus -0.35. Tpeak-Tend interval, skewness, and kurtosis were independent of age, sex, and heart rate (r2 < 0.05), whereas Bazett-corrected QT-interval was more dependent (r2 = 0.40). Conclusion: A selection of T-wave morphology variables is found to be clinically independent of age, sex, and heart rate, including Tpeak-Tend interval, skewness, and kurtosis.
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Electrocardiography
KW - Female
KW - Heart Conduction System
KW - Heart Rate
KW - Humans
KW - Male
KW - Middle Aged
KW - Minnesota
KW - Reference Values
KW - Reproducibility of Results
KW - Sensitivity and Specificity
KW - Young Adult
U2 - 10.1016/j.jelectrocard.2009.08.001
DO - 10.1016/j.jelectrocard.2009.08.001
M3 - Journal article
C2 - 19740481
SN - 0022-0736
VL - 43
SP - 31
EP - 39
JO - Journal of Electrocardiology
JF - Journal of Electrocardiology
IS - 1
ER -