TY - JOUR
T1 - Recent advances and potential applications of modulated differential scanning calorimetry (mDSC) in drug development
AU - Knopp, Matthias Manne
AU - Löbmann, Korbinian
AU - Elder, David P.
AU - Rades, Thomas
AU - Holm, René
PY - 2016/5/25
Y1 - 2016/5/25
N2 - Differential scanning calorimetry (DSC) is frequently the thermal analysis technique of choice within preformulation and formulation sciences because of its ability to provide detailed information about both the physical and energetic properties of a substance and/or formulation. However, conventional DSC has shortcomings with respect to weak transitions and overlapping events, which could be solved by the use of the more sophisticated modulated DSC (mDSC). mDSC has multiple potential applications within the pharmaceutical field and the present review provides an up-to-date overview of these applications. It is aimed to serve as a broad introduction to newcomers, and also as a valuable reference for those already practising in the field. Complex mDSC was introduced more than two decades ago and has been an important tool for the quantification of amorphous materials and development of freeze-dried formulations. However, as discussed in the present review, a number of other potential applications could also be relevant for the pharmaceutical scientist.
AB - Differential scanning calorimetry (DSC) is frequently the thermal analysis technique of choice within preformulation and formulation sciences because of its ability to provide detailed information about both the physical and energetic properties of a substance and/or formulation. However, conventional DSC has shortcomings with respect to weak transitions and overlapping events, which could be solved by the use of the more sophisticated modulated DSC (mDSC). mDSC has multiple potential applications within the pharmaceutical field and the present review provides an up-to-date overview of these applications. It is aimed to serve as a broad introduction to newcomers, and also as a valuable reference for those already practising in the field. Complex mDSC was introduced more than two decades ago and has been an important tool for the quantification of amorphous materials and development of freeze-dried formulations. However, as discussed in the present review, a number of other potential applications could also be relevant for the pharmaceutical scientist.
U2 - 10.1016/j.ejps.2015.12.024
DO - 10.1016/j.ejps.2015.12.024
M3 - Journal article
C2 - 26721421
SN - 0928-0987
VL - 87
SP - 164
EP - 173
JO - Norvegica Pharmaceutica Acta
JF - Norvegica Pharmaceutica Acta
ER -