Quantification of the enantiomeric excess of two APIs by means of near infrared spectroscopy and chemometrics

TY - JOUR

T1 - Quantification of the enantiomeric excess of two APIs by means of near infrared spectroscopy and chemometrics

AU - Rigoni, Lorenzo

AU - Venti, Sara

AU - Bevilacqua, Marta

AU - Bucci, Remo

AU - Magrì, Andrea D.

AU - Magrì, Antonio L.

AU - Marini, Federico

PY - 2014/4/15

Y1 - 2014/4/15

N2 - A method for the quantification of the enantiomeric excess of two pharmaceutical active ingredients (ibuprofen and epinephrine) in the solid state based on coupling near infrared spectroscopy and chemometrics is proposed. In the case of ibuprofen, in the absence of excipients, the method resulted in an accurate prediction of the enantiopurity of the validation samples (RMSEP

AB - A method for the quantification of the enantiomeric excess of two pharmaceutical active ingredients (ibuprofen and epinephrine) in the solid state based on coupling near infrared spectroscopy and chemometrics is proposed. In the case of ibuprofen, in the absence of excipients, the method resulted in an accurate prediction of the enantiopurity of the validation samples (RMSEP

KW - Enantiomeric excess

KW - Near infrared spectroscopy (NIR)

KW - Ibuprofen

KW - Epinephrine

KW - Partial least squares (PLS) regression

U2 - 10.1016/j.chemolab.2014.02.004

DO - 10.1016/j.chemolab.2014.02.004

M3 - Journal article

SN - 0169-7439

VL - 133

SP - 149

EP - 156

JO - Chemometrics and Intelligent Laboratory Systems

JF - Chemometrics and Intelligent Laboratory Systems

ER -