@article{f000e130b27911debc73000ea68e967b,
title = "Pseudomonas aeruginosa quorum-sensing signal molecules interfere with dendritic cell-induced T-cell proliferation",
abstract = "Pseudomonas aeruginosa releases a wide array of toxins and tissue-degrading enzymes. Production of these malicious virulence factors is controlled by interbacterial communication in a process known as quorum sensing. An increasing body of evidence reveals that the bacterial signal molecule N-(3-oxododecanoyl)-L-homoserine lactone (OdDHL) exhibits both quorum-sensing signalling and immune-modulating properties. Recently, yet another quorum-sensing signal molecule, the Pseudomonas quinolone signal (PQS), has been shown to affect cytokine release by mitogen-stimulated human T cells. In the present article we demonstrate that both OdDHL and PQS decrease the production of interleukin-12 (IL-12) by Escherichia coli lipopolysaccharide-stimulated bone marrow-derived dendritic cells (BM-DCs) without altering their IL-10 release. Moreover, BM-DCs exposed to PQS and OdDHL during antigen stimulation exhibit a decreased ability to induce T-cell proliferation in vitro. Collectively, this suggests that OdDHL and PQS change the maturation pattern of stimulated DCs away from a proinflammatory T-helper type I directing response, thereby decreasing the antibacterial activity of the adaptive immune defence. OdDHL and PQS thus seem to possess dual activities in the infection process: as inducers of virulence factors as well as immune-modulators facilitating the infective properties of this pathogen.",
author = "Skindersoe, {Mette E} and Zeuthen, {Louise H} and Susanne Brix and Fink, {Lisbeth N} and James Lazenby and Christine Whittall and Paul Williams and Diggle, {Stephen P} and Hanne Froekiaer and Margaret Cooley and Michael Givskov",
note = "Keywords: 4-Butyrolactone; Animals; Cell Proliferation; Dendritic Cells; Homoserine; Immunologic Factors; Mice; Mice, Inbred C57BL; Pseudomonas aeruginosa; Quinolones; T-Lymphocytes",
year = "2009",
doi = "10.1111/j.1574-695X.2008.00533.x",
language = "English",
volume = "55",
pages = "335--45",
journal = "Pathogens and Disease",
issn = "2049-632X",
publisher = "Wiley-Blackwell",
number = "3",
}