Prospective studies exploring the possible impact of an ID3 polymorphism on changes in obesity measures

TY - JOUR

T1 - Prospective studies exploring the possible impact of an ID3 polymorphism on changes in obesity measures

AU - Svendstrup, Mathilde

AU - Appel, Emil V.R.

AU - Sandholt, Camilla H.

AU - Ahluwalia, Tarunveer S.

AU - Ängquist, Lars H.

AU - Thuesen, Betina H.

AU - Jørgensen, Marit E.

AU - Pedersen, Oluf

AU - Grarup, Niels

AU - Hansen, Torben

AU - Sørensen, Thorkild I.A.

AU - Vestergaard, Henrik

N1 - © 2018 The Obesity Society.

PY - 2018

Y1 - 2018

N2 - OBJECTIVE: Changes in fat mass depend on adipogenesis and angiogenesis, mechanisms regulated by the inhibitor of differentiation-3 (ID3). Id3 knockout mice showed attenuated increases in BMI and visceral fat mass. We hypothesized that the ID3 missense variant (rs11574-A) would lead to an attenuated increase over time in fat mass, BMI, waist circumference (WC), and waist-hip ratio (WHR) in humans.METHODS: The genotyped study populations included the Obesity Research Group - Genetics (ORGGEN) cohort, a cohort of men with obesity (N = 716) and of randomly selected men (N = 826) from the Danish draft register who were examined at mean ages of 20 and 46 years, and the Inter99 (N = 6,116) and Health2006 (N = 2,761) cohorts, two population-based samples of middle-aged people, followed up after 5 years.RESULTS: In meta-analyses of all data, no association was found between rs11574-A and changes in BMI, WC, WHR, or fat mass. We found an association between rs11574-A and cross-sectional BMI (N = 10,359, β: -0.16 kg/m2per allele, 95% CI: -0.30 to -0.01, P = 0.033) and fat mass (N = 4,188, β: -0.52 kg/m2per allele, 95% CI: -1.03 to -0.01, P = 0.046).CONCLUSIONS: No consistent impact of the genetic variant on changes in fat mass, BMI, or fat distribution was found in three Danish cohorts.

AB - OBJECTIVE: Changes in fat mass depend on adipogenesis and angiogenesis, mechanisms regulated by the inhibitor of differentiation-3 (ID3). Id3 knockout mice showed attenuated increases in BMI and visceral fat mass. We hypothesized that the ID3 missense variant (rs11574-A) would lead to an attenuated increase over time in fat mass, BMI, waist circumference (WC), and waist-hip ratio (WHR) in humans.METHODS: The genotyped study populations included the Obesity Research Group - Genetics (ORGGEN) cohort, a cohort of men with obesity (N = 716) and of randomly selected men (N = 826) from the Danish draft register who were examined at mean ages of 20 and 46 years, and the Inter99 (N = 6,116) and Health2006 (N = 2,761) cohorts, two population-based samples of middle-aged people, followed up after 5 years.RESULTS: In meta-analyses of all data, no association was found between rs11574-A and changes in BMI, WC, WHR, or fat mass. We found an association between rs11574-A and cross-sectional BMI (N = 10,359, β: -0.16 kg/m2per allele, 95% CI: -0.30 to -0.01, P = 0.033) and fat mass (N = 4,188, β: -0.52 kg/m2per allele, 95% CI: -1.03 to -0.01, P = 0.046).CONCLUSIONS: No consistent impact of the genetic variant on changes in fat mass, BMI, or fat distribution was found in three Danish cohorts.

KW - Journal Article

KW - Body Mass Index

KW - Prospective Studies

KW - Humans

KW - Middle Aged

KW - Risk Factors

KW - Genotype

KW - Male

KW - Case-Control Studies

KW - Mice, Knockout

KW - Obesity/genetics

KW - Young Adult

KW - Animals

KW - Neoplasm Proteins/genetics

KW - Inhibitor of Differentiation Proteins/genetics

KW - Adult

KW - Female

KW - Mice

U2 - 10.1002/oby.22109

DO - 10.1002/oby.22109

M3 - Journal article

C2 - 29442437

SN - 1930-7381

VL - 26

SP - 747

EP - 754

JO - Obesity

JF - Obesity

IS - 4

ER -