Process development for spray drying of sticky pharmaceuticals; case study of bioadhesive nicotine microparticles for compressed medicated chewing gum

Camilla Sander; Henrik Stillhof Nielsen; Susanne Roslev Søgaard; Celina Støving; Mingshi Yang; Jette Jacobsen; Jukka Rantanen

doi:10.1016/j.ijpharm.2013.04.082

Process development for spray drying of sticky pharmaceuticals; case study of bioadhesive nicotine microparticles for compressed medicated chewing gum

Camilla Sander, Henrik Stillhof Nielsen, Susanne Roslev Søgaard, Celina Støving, Mingshi Yang, Jette Jacobsen, Jukka Rantanen

2 Citationer (Scopus)

Abstract

Spray drying of pharmaceutical compounds with sticky properties is a challenging task and may require substantial time and resources. By including small-scale studies of single droplet drying kinetics a relatively high number of experiments with less material is allowed. This means one can construct a more robust design space according to Quality by Design (QbD) formulation development principles. In the current study we present a case study on the development of spray dried microparticles comprising nicotine bitartrate and hypromellose or alginate polymer, for incorporation into medicated chewing gum. By illustration of initial studies on single droplet drying kinetics, subsequent characterization of microparticles, and final characterization of compressed chewing gum this paper summarizes the entire development process.

Originalsprog	Engelsk
Tidsskrift	International Journal of Pharmaceutics
Vol/bind	452
Udgave nummer	1-2
Sider (fra-til)	434-7
Antal sider	4
ISSN	0378-5173
DOI	https://doi.org/10.1016/j.ijpharm.2013.04.082
Status	Udgivet - 16 aug. 2013

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10.1016/j.ijpharm.2013.04.082

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Process development for spray drying of sticky pharmaceuticals; case study of bioadhesive nicotine microparticles for compressed medicated chewing gum. / Sander, Camilla; Nielsen, Henrik Stillhof; Søgaard, Susanne Roslev et al.

I: International Journal of Pharmaceutics, Bind 452, Nr. 1-2, 16.08.2013, s. 434-7.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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abstract = "Spray drying of pharmaceutical compounds with sticky properties is a challenging task and may require substantial time and resources. By including small-scale studies of single droplet drying kinetics a relatively high number of experiments with less material is allowed. This means one can construct a more robust design space according to Quality by Design (QbD) formulation development principles. In the current study we present a case study on the development of spray dried microparticles comprising nicotine bitartrate and hypromellose or alginate polymer, for incorporation into medicated chewing gum. By illustration of initial studies on single droplet drying kinetics, subsequent characterization of microparticles, and final characterization of compressed chewing gum this paper summarizes the entire development process.",

keywords = "Alginates, Chewing Gum, Desiccation, Drug Delivery Systems, Glucuronic Acid, Hexuronic Acids, Mannitol, Methylcellulose, Nicotine, Technology, Pharmaceutical",

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AU - Sander, Camilla

AU - Nielsen, Henrik Stillhof

AU - Søgaard, Susanne Roslev

AU - Støving, Celina

AU - Yang, Mingshi

AU - Jacobsen, Jette

AU - Rantanen, Jukka

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AB - Spray drying of pharmaceutical compounds with sticky properties is a challenging task and may require substantial time and resources. By including small-scale studies of single droplet drying kinetics a relatively high number of experiments with less material is allowed. This means one can construct a more robust design space according to Quality by Design (QbD) formulation development principles. In the current study we present a case study on the development of spray dried microparticles comprising nicotine bitartrate and hypromellose or alginate polymer, for incorporation into medicated chewing gum. By illustration of initial studies on single droplet drying kinetics, subsequent characterization of microparticles, and final characterization of compressed chewing gum this paper summarizes the entire development process.

KW - Alginates

KW - Chewing Gum

KW - Desiccation

KW - Drug Delivery Systems

KW - Glucuronic Acid

KW - Hexuronic Acids

KW - Mannitol

KW - Methylcellulose

KW - Nicotine

KW - Technology, Pharmaceutical

U2 - 10.1016/j.ijpharm.2013.04.082

DO - 10.1016/j.ijpharm.2013.04.082

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Process development for spray drying of sticky pharmaceuticals; case study of bioadhesive nicotine microparticles for compressed medicated chewing gum

Abstract

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