PNA Directed Sequence Addressed Self-Assembly of DNA Nanostructures

Peter E. Nielsen

PNA Directed Sequence Addressed Self-Assembly of DNA Nanostructures

Institut for Cellulær og Molekylær Medicin

1 Citationer (Scopus)

Abstract

Peptide nucleic acids (PNA) can be designed to target duplex DNA with very high sequence specificity and efficiency via various binding modes. We have designed three domain PNA clamps, that bind stably to predefined decameric homopurine targets in large dsDNA mols. and via a third PNA domain sequence specifically recognize another PNA oligomer. We describe how such three domain PNAs have utility for assembling dsDNA grid and clover leaf structures, and in combination with SNAP-tag technol. of protein dsDNA structures. (c) 2008 American Institute of Physics. [on SciFinder (R)]
Udgivelsesdato: 2008

Originalsprog	Dansk
Tidsskrift	AIP Conference Proceedings
Vol/bind	1062
Udgave nummer	DNA-Based Nanodevices
Sider (fra-til)	13-18
Antal sider	5
ISSN	0094-243X
Status	Udgivet - 2008

Citationsformater

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N2 - Peptide nucleic acids (PNA) can be designed to target duplex DNA with very high sequence specificity and efficiency via various binding modes. We have designed three domain PNA clamps, that bind stably to predefined decameric homopurine targets in large dsDNA mols. and via a third PNA domain sequence specifically recognize another PNA oligomer. We describe how such three domain PNAs have utility for assembling dsDNA grid and clover leaf structures, and in combination with SNAP-tag technol. of protein dsDNA structures. (c) 2008 American Institute of Physics. [on SciFinder (R)] Udgivelsesdato: 2008

AB - Peptide nucleic acids (PNA) can be designed to target duplex DNA with very high sequence specificity and efficiency via various binding modes. We have designed three domain PNA clamps, that bind stably to predefined decameric homopurine targets in large dsDNA mols. and via a third PNA domain sequence specifically recognize another PNA oligomer. We describe how such three domain PNAs have utility for assembling dsDNA grid and clover leaf structures, and in combination with SNAP-tag technol. of protein dsDNA structures. (c) 2008 American Institute of Physics. [on SciFinder (R)] Udgivelsesdato: 2008

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