Peptide nucleic acid (PNA): a model structure for the primordial genetic material?

Peter E. Nielsen

Peptide nucleic acid (PNA): a model structure for the primordial genetic material?

Transcription, RNA, and Gene Medicine Program

Abstract

It is proposed that the primordial genetic material could have been peptide nucleic acids, i.e., DNA analogues having a peptide backbone. PNA monomers based on the amino acid, alpha, gamma-diaminobutyric acid or ornithine are suggested as compounds that could have been formed in the prebiotic soup. Finally, the possibility of a PNA/RNA world is presented, in which PNA constitutes the stable genetic material, while RNA which may be polymerized using the PNA as template accounts for enzymatic activities including PNA replication.

Originalsprog	Engelsk
Tidsskrift	Origins of Life and Evolution of Biospheres
Vol/bind	23
Udgave nummer	5-6
Sider (fra-til)	323-7
Antal sider	5
ISSN	0169-6149
Status	Udgivet - dec. 1993

Citationsformater

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abstract = "It is proposed that the primordial genetic material could have been peptide nucleic acids, i.e., DNA analogues having a peptide backbone. PNA monomers based on the amino acid, alpha, gamma-diaminobutyric acid or ornithine are suggested as compounds that could have been formed in the prebiotic soup. Finally, the possibility of a PNA/RNA world is presented, in which PNA constitutes the stable genetic material, while RNA which may be polymerized using the PNA as template accounts for enzymatic activities including PNA replication.",

keywords = "Base Sequence, DNA/chemistry, Models, Chemical, Models, Genetic, Molecular Conformation, Molecular Sequence Data, Molecular Structure, Nucleic Acids/chemistry, Peptides/chemistry, RNA, Catalytic/chemistry",

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AU - Nielsen, Peter E.

PY - 1993/12

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N2 - It is proposed that the primordial genetic material could have been peptide nucleic acids, i.e., DNA analogues having a peptide backbone. PNA monomers based on the amino acid, alpha, gamma-diaminobutyric acid or ornithine are suggested as compounds that could have been formed in the prebiotic soup. Finally, the possibility of a PNA/RNA world is presented, in which PNA constitutes the stable genetic material, while RNA which may be polymerized using the PNA as template accounts for enzymatic activities including PNA replication.

AB - It is proposed that the primordial genetic material could have been peptide nucleic acids, i.e., DNA analogues having a peptide backbone. PNA monomers based on the amino acid, alpha, gamma-diaminobutyric acid or ornithine are suggested as compounds that could have been formed in the prebiotic soup. Finally, the possibility of a PNA/RNA world is presented, in which PNA constitutes the stable genetic material, while RNA which may be polymerized using the PNA as template accounts for enzymatic activities including PNA replication.

KW - Base Sequence

KW - DNA/chemistry

KW - Models, Chemical

KW - Models, Genetic

KW - Molecular Conformation

KW - Molecular Sequence Data

KW - Molecular Structure

KW - Nucleic Acids/chemistry

KW - Peptides/chemistry

KW - RNA, Catalytic/chemistry

M3 - Journal article

C2 - 8115163

SN - 0169-6149

VL - 23

SP - 323

EP - 327

JO - Origins of Life and Evolution of Biospheres

JF - Origins of Life and Evolution of Biospheres

IS - 5-6

ER -

Peptide nucleic acid (PNA): a model structure for the primordial genetic material?

Abstract

Fingeraftryk

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