Parallel adaptation of rabbit populations to myxoma virus

Joel M. Alves; Miguel Carneiro; Jade Y. Cheng; Ana Lemos de Matos; Masmudur M. Rahman; Liisa Loog; Paula F. Campos; Nathan Wales; Anders Eriksson; Andrea Manica; Tanja Strive; Stephen C. Graham; Sandra Afonso; Diana J. Bell; Laura Belmont; Jonathan P. Day; Susan J. Fuller; Stéphane Marchandeau; William J. Palmer; Guillaume Queney; Alison K. Surridge; Filipe G. Vieira; Grant McFadden; Rasmus Nielsen; M. Thomas P. Gilbert; Pedro J. Esteves; Nuno Ferrand; Francis M. Jiggins

doi:10.1126/science.aau7285

Parallel adaptation of rabbit populations to myxoma virus

Joel M. Alves^*, Miguel Carneiro, Jade Y. Cheng, Ana Lemos de Matos, Masmudur M. Rahman, Liisa Loog, Paula F. Campos, Nathan Wales, Anders Eriksson, Andrea Manica, Tanja Strive, Stephen C. Graham, Sandra Afonso, Diana J. Bell, Laura Belmont, Jonathan P. Day, Susan J. Fuller, Stéphane Marchandeau, William J. Palmer, Guillaume QueneyAlison K. Surridge, Filipe G. Vieira, Grant McFadden, Rasmus Nielsen, M. Thomas P. Gilbert, Pedro J. Esteves, Nuno Ferrand, Francis M. Jiggins

^*Corresponding author af dette arbejde

34 Citationer (Scopus)

Abstract

In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased the protein’s antiviral effect.

Originalsprog	Engelsk
Tidsskrift	Science
Vol/bind	363
Udgave nummer	6433
ISSN	0036-8075
DOI	https://doi.org/10.1126/science.aau7285
Status	Udgivet - 22 mar. 2019

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10.1126/science.aau7285

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Alves, J. M., Carneiro, M., Cheng, J. Y., Matos, A. L. D., Rahman, M. M., Loog, L., Campos, P. F., Wales, N., Eriksson, A., Manica, A., Strive, T., Graham, S. C., Afonso, S., Bell, D. J., Belmont, L., Day, J. P., Fuller, S. J., Marchandeau, S., Palmer, W. J., ... Jiggins, F. M. (2019). Parallel adaptation of rabbit populations to myxoma virus. Science, 363(6433). https://doi.org/10.1126/science.aau7285

Alves, JM, Carneiro, M, Cheng, JY, Matos, ALD, Rahman, MM, Loog, L, Campos, PF, Wales, N, Eriksson, A, Manica, A, Strive, T, Graham, SC, Afonso, S, Bell, DJ, Belmont, L, Day, JP, Fuller, SJ, Marchandeau, S, Palmer, WJ, Queney, G, Surridge, AK, Vieira, FG, McFadden, G, Nielsen, R, Gilbert, MTP, Esteves, PJ, Ferrand, N & Jiggins, FM 2019, 'Parallel adaptation of rabbit populations to myxoma virus', Science, bind 363, nr. 6433. https://doi.org/10.1126/science.aau7285

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title = "Parallel adaptation of rabbit populations to myxoma virus",

abstract = "In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased the protein{\textquoteright}s antiviral effect.",

author = "Alves, {Joel M.} and Miguel Carneiro and Cheng, {Jade Y.} and Matos, {Ana Lemos de} and Rahman, {Masmudur M.} and Liisa Loog and Campos, {Paula F.} and Nathan Wales and Anders Eriksson and Andrea Manica and Tanja Strive and Graham, {Stephen C.} and Sandra Afonso and Bell, {Diana J.} and Laura Belmont and Day, {Jonathan P.} and Fuller, {Susan J.} and St{\'e}phane Marchandeau and Palmer, {William J.} and Guillaume Queney and Surridge, {Alison K.} and Vieira, {Filipe G.} and Grant McFadden and Rasmus Nielsen and Gilbert, {M. Thomas P.} and Esteves, {Pedro J.} and Nuno Ferrand and Jiggins, {Francis M.}",

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doi = "10.1126/science.aau7285",

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T1 - Parallel adaptation of rabbit populations to myxoma virus

AU - Alves, Joel M.

AU - Carneiro, Miguel

AU - Cheng, Jade Y.

AU - Matos, Ana Lemos de

AU - Rahman, Masmudur M.

AU - Loog, Liisa

AU - Campos, Paula F.

AU - Wales, Nathan

AU - Eriksson, Anders

AU - Manica, Andrea

AU - Strive, Tanja

AU - Graham, Stephen C.

AU - Afonso, Sandra

AU - Bell, Diana J.

AU - Belmont, Laura

AU - Day, Jonathan P.

AU - Fuller, Susan J.

AU - Marchandeau, Stéphane

AU - Palmer, William J.

AU - Queney, Guillaume

AU - Surridge, Alison K.

AU - Vieira, Filipe G.

AU - McFadden, Grant

AU - Nielsen, Rasmus

AU - Gilbert, M. Thomas P.

AU - Esteves, Pedro J.

AU - Ferrand, Nuno

AU - Jiggins, Francis M.

PY - 2019/3/22

Y1 - 2019/3/22

N2 - In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased the protein’s antiviral effect.

AB - In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased the protein’s antiviral effect.

U2 - 10.1126/science.aau7285

DO - 10.1126/science.aau7285

M3 - Journal article

C2 - 30765607

AN - SCOPUS:85061759943

SN - 0036-8075

VL - 363

JO - Science

JF - Science

IS - 6433

ER -

Parallel adaptation of rabbit populations to myxoma virus

Abstract

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