Obstetric synthetic oxytocin use and subsequent hyperactivity/inattention problems in Danish children

TY - JOUR

T1 - Obstetric synthetic oxytocin use and subsequent hyperactivity/inattention problems in Danish children

AU - Stokholm, Lonny

AU - Juhl, Mette

AU - Lønfeldt, Nicole N

AU - Mikkelsen, Susanne H

AU - Obel, Carsten

AU - Strandberg-Larsen, Katrine

N1 - © 2018 Nordic Federation of Societies of Obstetrics and Gynecology.

PY - 2018/7

Y1 - 2018/7

N2 - Introduction: The objective was to examine the association between obstetric synthetic oxytocin use and hyperactivity/inattention problems in offspring. Material and methods: We identified children born in 2000–2003, enrolled in the Danish National Birth Cohort, with data on the Strengths and Difficulties Questionnaire (SDQ) reported by parents at age seven (n = 33 896) and age 11 (n = 27 561) and the children themselves around age 11 (n = 27 251). Information on oxytocin administration was provided in the Medical Birth Register. We estimated mean differences and odds ratios for childhood hyperactivity/inattention problems according to oxytocin exposure. Results: Synthetic oxytocin was administered in 26% of the deliveries. We did not find the use of synthetic oxytocin during birth to be associated with childhood hyperactivity/inattention problems, whether analyzed in linear or logistic regression models. Conclusions: Our findings do not support any effects of obstetric use of synthetic oxytocin on hyperactivity/inattention problems in children when measured with the SDQ subscale at 7 or 11 years of age.

AB - Introduction: The objective was to examine the association between obstetric synthetic oxytocin use and hyperactivity/inattention problems in offspring. Material and methods: We identified children born in 2000–2003, enrolled in the Danish National Birth Cohort, with data on the Strengths and Difficulties Questionnaire (SDQ) reported by parents at age seven (n = 33 896) and age 11 (n = 27 561) and the children themselves around age 11 (n = 27 251). Information on oxytocin administration was provided in the Medical Birth Register. We estimated mean differences and odds ratios for childhood hyperactivity/inattention problems according to oxytocin exposure. Results: Synthetic oxytocin was administered in 26% of the deliveries. We did not find the use of synthetic oxytocin during birth to be associated with childhood hyperactivity/inattention problems, whether analyzed in linear or logistic regression models. Conclusions: Our findings do not support any effects of obstetric use of synthetic oxytocin on hyperactivity/inattention problems in children when measured with the SDQ subscale at 7 or 11 years of age.

U2 - 10.1111/aogs.13344

DO - 10.1111/aogs.13344

M3 - Journal article

C2 - 29574678

SN - 0001-6349

VL - 97

SP - 880

EP - 889

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

IS - 7

ER -