Nuclear magnetic resonance-based metabolomics reveals that dairy protein fractions affect urinary urea excretion differently in overweight adolescents

Hong Zheng; Christian C. Yde; Trine K. Dalsgaard; Karina Arnberg; Christian Mølgaard; Kim F. Michaelsen; Anni Larnkjær; Hanne C. Bertram

doi:10.1007/s00217-014-2347-0

Nuclear magnetic resonance-based metabolomics reveals that dairy protein fractions affect urinary urea excretion differently in overweight adolescents

Hong Zheng, Christian C. Yde, Trine K. Dalsgaard, Karina Arnberg, Christian Mølgaard, Kim F. Michaelsen, Anni Larnkjær, Hanne C. Bertram^*

^*Corresponding author af dette arbejde

Ernæring og Sundhed hos børn og voksne

5 Citationer (Scopus)

Abstract

Dairy proteins are an important part of our diet, and recently, there is considerable focus on understanding the effects of the two major dairy proteins fractions constituted by casein and whey. In the present study, the impact of a dietary intervention with casein, whey, and skim milk was investigated by using NMR-based urine metabolomics. Overweight adolescents (n = 192; age = 12–15 years; BMI = 25.4 ± 2.3 kg/m²) were randomly assigned to 1 L/day of casein (citrate content: 3.27 mol/L), whey (citrate content: 0.04 mol/L), skim milk, or water for 12 weeks. A significant increase in the urinary excretion of urea was found after the 12-week casein and skim milk interventions, while the 12-week whey intervention had no significant effect on the urea excretion. In addition, NMR-based metabolomics revealed a decreased urinary citrate excretion in the whey group and thereby demonstrated its potential to disclosure exposure effects. In conclusion, the present study demonstrates that casein and whey proteins impact urinary urea excretion differently.

Originalsprog	Engelsk
Tidsskrift	European Food Research and Technology
Vol/bind	240
Udgave nummer	3
Sider (fra-til)	489-497
Antal sider	9
ISSN	1438-2377
DOI	https://doi.org/10.1007/s00217-014-2347-0
Status	Udgivet - mar. 2014

Adgang til dokumentet

10.1007/s00217-014-2347-0

Citationsformater

Zheng, H., Yde, C. C., Dalsgaard, T. K., Arnberg, K., Mølgaard, C., Michaelsen, K. F., Larnkjær, A., & Bertram, H. C. (2014). Nuclear magnetic resonance-based metabolomics reveals that dairy protein fractions affect urinary urea excretion differently in overweight adolescents. European Food Research and Technology, 240(3), 489-497. https://doi.org/10.1007/s00217-014-2347-0

Nuclear magnetic resonance-based metabolomics reveals that dairy protein fractions affect urinary urea excretion differently in overweight adolescents. / Zheng, Hong; Yde, Christian C.; Dalsgaard, Trine K. et al.
I: European Food Research and Technology, Bind 240, Nr. 3, 03.2014, s. 489-497.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Zheng, H, Yde, CC, Dalsgaard, TK, Arnberg, K, Mølgaard, C , Michaelsen, KF , Larnkjær, A & Bertram, HC 2014, 'Nuclear magnetic resonance-based metabolomics reveals that dairy protein fractions affect urinary urea excretion differently in overweight adolescents', European Food Research and Technology, bind 240, nr. 3, s. 489-497. https://doi.org/10.1007/s00217-014-2347-0

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title = "Nuclear magnetic resonance-based metabolomics reveals that dairy protein fractions affect urinary urea excretion differently in overweight adolescents",

abstract = "Dairy proteins are an important part of our diet, and recently, there is considerable focus on understanding the effects of the two major dairy proteins fractions constituted by casein and whey. In the present study, the impact of a dietary intervention with casein, whey, and skim milk was investigated by using NMR-based urine metabolomics. Overweight adolescents (n = 192; age = 12–15 years; BMI = 25.4 ± 2.3 kg/m2) were randomly assigned to 1 L/day of casein (citrate content: 3.27 mol/L), whey (citrate content: 0.04 mol/L), skim milk, or water for 12 weeks. A significant increase in the urinary excretion of urea was found after the 12-week casein and skim milk interventions, while the 12-week whey intervention had no significant effect on the urea excretion. In addition, NMR-based metabolomics revealed a decreased urinary citrate excretion in the whey group and thereby demonstrated its potential to disclosure exposure effects. In conclusion, the present study demonstrates that casein and whey proteins impact urinary urea excretion differently.",

keywords = "Casein, Citrate, Metabolomics, Milk protein, Urea, Whey",

author = "Hong Zheng and Yde, {Christian C.} and Dalsgaard, {Trine K.} and Karina Arnberg and Christian M{\o}lgaard and Michaelsen, {Kim F.} and Anni Larnkj{\ae}r and Bertram, {Hanne C.}",

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AU - Zheng, Hong

AU - Yde, Christian C.

AU - Dalsgaard, Trine K.

AU - Arnberg, Karina

AU - Mølgaard, Christian

AU - Michaelsen, Kim F.

AU - Larnkjær, Anni

AU - Bertram, Hanne C.

N1 - CURIS 2015 NEXS 409

PY - 2014/3

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N2 - Dairy proteins are an important part of our diet, and recently, there is considerable focus on understanding the effects of the two major dairy proteins fractions constituted by casein and whey. In the present study, the impact of a dietary intervention with casein, whey, and skim milk was investigated by using NMR-based urine metabolomics. Overweight adolescents (n = 192; age = 12–15 years; BMI = 25.4 ± 2.3 kg/m2) were randomly assigned to 1 L/day of casein (citrate content: 3.27 mol/L), whey (citrate content: 0.04 mol/L), skim milk, or water for 12 weeks. A significant increase in the urinary excretion of urea was found after the 12-week casein and skim milk interventions, while the 12-week whey intervention had no significant effect on the urea excretion. In addition, NMR-based metabolomics revealed a decreased urinary citrate excretion in the whey group and thereby demonstrated its potential to disclosure exposure effects. In conclusion, the present study demonstrates that casein and whey proteins impact urinary urea excretion differently.

AB - Dairy proteins are an important part of our diet, and recently, there is considerable focus on understanding the effects of the two major dairy proteins fractions constituted by casein and whey. In the present study, the impact of a dietary intervention with casein, whey, and skim milk was investigated by using NMR-based urine metabolomics. Overweight adolescents (n = 192; age = 12–15 years; BMI = 25.4 ± 2.3 kg/m2) were randomly assigned to 1 L/day of casein (citrate content: 3.27 mol/L), whey (citrate content: 0.04 mol/L), skim milk, or water for 12 weeks. A significant increase in the urinary excretion of urea was found after the 12-week casein and skim milk interventions, while the 12-week whey intervention had no significant effect on the urea excretion. In addition, NMR-based metabolomics revealed a decreased urinary citrate excretion in the whey group and thereby demonstrated its potential to disclosure exposure effects. In conclusion, the present study demonstrates that casein and whey proteins impact urinary urea excretion differently.

KW - Casein

KW - Citrate

KW - Metabolomics

KW - Milk protein

KW - Urea

KW - Whey

U2 - 10.1007/s00217-014-2347-0

DO - 10.1007/s00217-014-2347-0

M3 - Journal article

AN - SCOPUS:84922565444

SN - 1438-2377

VL - 240

SP - 489

EP - 497

JO - European Food Research and Technology

JF - European Food Research and Technology

IS - 3

ER -

Nuclear magnetic resonance-based metabolomics reveals that dairy protein fractions affect urinary urea excretion differently in overweight adolescents

Abstract

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