Non-invasive study of nerve fibres using laser interference microscopy

Alexey Brazhe; Nadezda Brazhe; N N Rodionova; A I Yusipovich; P S Ignatyev; G V Maksimov; Erik Mosekilde; Olga Sosnovtseva

doi:10.1098/rsta.2008.0107

Non-invasive study of nerve fibres using laser interference microscopy

Alexey Brazhe, Nadezda Brazhe, N N Rodionova, A I Yusipovich, P S Ignatyev, G V Maksimov, Erik Mosekilde, Olga Sosnovtseva

Nyre- og Karforskning

20 Citationer (Scopus)

Abstract

This paper presents the results of a laser interference microscopy study of the morphology and dynamical properties of myelinated nerve fibres. We describe the principles of operation of the phase-modulated laser interference microscope and show how this novel technique allows us to obtain information non-invasively about the internal structure of different regions of a nerve fibre. We also analyse the temporal variations in the internal optical properties in order to detect the rhythmic activity in the nerve fibre at different time scales and to shed light on the underlying biological processes. We observe pronounced frequencies in the dynamics of the optical properties and suggest that the oscillatory modes have similar origin in different regions, but different strengths and mutual modulation properties.

Originalsprog	Engelsk
Tidsskrift	Royal Society of London. Philosophical Transactions. Mathematical, Physical and Engineering Sciences
Vol/bind	366
Udgave nummer	1880
Sider (fra-til)	3463-81
Antal sider	19
ISSN	1364-503X
DOI	https://doi.org/10.1098/rsta.2008.0107
Status	Udgivet - 13 okt. 2008

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10.1098/rsta.2008.0107

Citationsformater

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title = "Non-invasive study of nerve fibres using laser interference microscopy",

abstract = "This paper presents the results of a laser interference microscopy study of the morphology and dynamical properties of myelinated nerve fibres. We describe the principles of operation of the phase-modulated laser interference microscope and show how this novel technique allows us to obtain information non-invasively about the internal structure of different regions of a nerve fibre. We also analyse the temporal variations in the internal optical properties in order to detect the rhythmic activity in the nerve fibre at different time scales and to shed light on the underlying biological processes. We observe pronounced frequencies in the dynamics of the optical properties and suggest that the oscillatory modes have similar origin in different regions, but different strengths and mutual modulation properties.",

keywords = "Animals, Equipment Design, Humans, Lasers, Light, Microscopy, Confocal, Microscopy, Interference, Models, Neurological, Models, Statistical, Myelin Sheath, Nerve Fibers, Neurons, Oscillometry, Time Factors",

author = "Alexey Brazhe and Nadezda Brazhe and Rodionova, {N N} and Yusipovich, {A I} and Ignatyev, {P S} and Maksimov, {G V} and Erik Mosekilde and Olga Sosnovtseva",

year = "2008",

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doi = "10.1098/rsta.2008.0107",

language = "English",

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T1 - Non-invasive study of nerve fibres using laser interference microscopy

AU - Brazhe, Alexey

AU - Brazhe, Nadezda

AU - Rodionova, N N

AU - Yusipovich, A I

AU - Ignatyev, P S

AU - Maksimov, G V

AU - Mosekilde, Erik

AU - Sosnovtseva, Olga

PY - 2008/10/13

Y1 - 2008/10/13

N2 - This paper presents the results of a laser interference microscopy study of the morphology and dynamical properties of myelinated nerve fibres. We describe the principles of operation of the phase-modulated laser interference microscope and show how this novel technique allows us to obtain information non-invasively about the internal structure of different regions of a nerve fibre. We also analyse the temporal variations in the internal optical properties in order to detect the rhythmic activity in the nerve fibre at different time scales and to shed light on the underlying biological processes. We observe pronounced frequencies in the dynamics of the optical properties and suggest that the oscillatory modes have similar origin in different regions, but different strengths and mutual modulation properties.

AB - This paper presents the results of a laser interference microscopy study of the morphology and dynamical properties of myelinated nerve fibres. We describe the principles of operation of the phase-modulated laser interference microscope and show how this novel technique allows us to obtain information non-invasively about the internal structure of different regions of a nerve fibre. We also analyse the temporal variations in the internal optical properties in order to detect the rhythmic activity in the nerve fibre at different time scales and to shed light on the underlying biological processes. We observe pronounced frequencies in the dynamics of the optical properties and suggest that the oscillatory modes have similar origin in different regions, but different strengths and mutual modulation properties.

KW - Animals

KW - Equipment Design

KW - Humans

KW - Lasers

KW - Light

KW - Microscopy, Confocal

KW - Microscopy, Interference

KW - Models, Neurological

KW - Models, Statistical

KW - Myelin Sheath

KW - Nerve Fibers

KW - Neurons

KW - Oscillometry

KW - Time Factors

U2 - 10.1098/rsta.2008.0107

DO - 10.1098/rsta.2008.0107

M3 - Journal article

C2 - 18644770

SN - 1364-503X

VL - 366

SP - 3463

EP - 3481

JO - Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

JF - Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

IS - 1880

ER -

Non-invasive study of nerve fibres using laser interference microscopy

Abstract

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