No effect on oxidative stress biomarkers by modified intakes of polyunsaturated fatty acids or vegetables and fruit

TY - JOUR

T1 - No effect on oxidative stress biomarkers by modified intakes of polyunsaturated fatty acids or vegetables and fruit

AU - Freese, R

AU - Dragsted, L O

AU - Loft, S

AU - Mutanen, M

N1 - Keywords: Adult; Biological Markers; Blood Proteins; DNA Damage; Deoxyguanosine; Erythrocytes; Fatty Acids, Unsaturated; Fruit; Glutathione Reductase; Humans; Middle Aged; Oxidative Stress; Superoxide Dismutase; Vegetables; Young Adult

PY - 2007

Y1 - 2007

N2 - Diet may both increase and decrease oxidative stress in the body. We compared the effects of four strictly controlled isocaloric diets with different intakes of polyunsaturated fatty acids (PUFA, 11 or 3% of energy) and vegetables and fruit (total amount of vegetables and fruit 516 or 1059 g/10 MJ) on markers associated with oxidative stress in 77 healthy volunteers (19-52 years). Plasma protein carbonyls (2-aminoadipic semialdehyde residues) and whole-body DNA and nucleotide oxidation (urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion) tended to decrease in all treatment groups with no differences between the diets. The diets did not differ in their effects on red blood cell antioxidative enzyme activities, either. The results suggest that in healthy volunteers with adequate nutrient intakes, 6-week diets differing markedly in the amount of PUFA or vegetables and fruit do not differ in their effects on markers associated with oxidative stress.

AB - Diet may both increase and decrease oxidative stress in the body. We compared the effects of four strictly controlled isocaloric diets with different intakes of polyunsaturated fatty acids (PUFA, 11 or 3% of energy) and vegetables and fruit (total amount of vegetables and fruit 516 or 1059 g/10 MJ) on markers associated with oxidative stress in 77 healthy volunteers (19-52 years). Plasma protein carbonyls (2-aminoadipic semialdehyde residues) and whole-body DNA and nucleotide oxidation (urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion) tended to decrease in all treatment groups with no differences between the diets. The diets did not differ in their effects on red blood cell antioxidative enzyme activities, either. The results suggest that in healthy volunteers with adequate nutrient intakes, 6-week diets differing markedly in the amount of PUFA or vegetables and fruit do not differ in their effects on markers associated with oxidative stress.

U2 - 10.1038/sj.ejcn.1602865

DO - 10.1038/sj.ejcn.1602865

M3 - Journal article

C2 - 17671440

SN - 0954-3007

VL - 62

SP - 1151

EP - 1153

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

IS - 9

ER -