Steffen Loft

CV

Born: 1 November, 1954 in Copenhagen

Citizenship: Danish

Married – three sons 

Address (private): Vingårds Alle 34, 2900 Hellerup, Denmark
Address (work): Section of Environmental Health, Dept. of Public Health, Øster Farimagsgade 5, DK 1014 K, Copenhagen, Denmark
Phone: (work) +4535327649; (mobile) +4526814889; (fax) +4535327610
E-mail: [email protected]

Education: Masters degree in Medicine, University of Copenhagen, January 1980

Academic degree: Dr. of Medical Science 1990

Appointments

1980-1986: Clinical appointments, mainly in internal medicine

1986-1998: Assistant professor, later associate professor in toxicology and environmental medicine at University of Copenhagen

From April 1998 onwards: Professor in Environmental Medicine at Department of Public Health, Faculty of Health Sciences, University of Copenhagen

Head of Section of Environmental Health, Dept. of Public Health, University of Copenhagen

2003-2010: Chairman of the Research Center for Environmental Health of the Danish Ministry for the Interior and Health, now Advisory Scientific Committee on Environmental Health, National Board of Health, Denmark

2007-2014 Member from 2013 Vicechairman of the board of The National Research Center for the Working Environment

2009-2015: Member of the Academic Council of the Health Science Faculty of University of Copenhagen

2015 and onwards: Head of Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen

Research interests

The aim of my research is to improve prevention of disease caused by environmental factors by better understanding the exposures and mechanisms involved. Particularly research in the fields of health effects ofparticles, molecular epidemiology, and oxidative DNA damage and repair.
The particle research comprises exposure and effects of outdoor and indoor air pollution as well as risks of engineered nanoparticles. The work spans the entire hierarchy of techniques from experimental models such as synthetic membranes, organotypic cell cultures and transgenic animals, the use of biomarkers and functional measures populationswith controlled exposure and interventions, to register-based epidemiology atthe aggregate level and influence of climate change. There is particular attention on mechanisms associated with oxidative stress-related genotoxic,vascular and aging effects in risk groups of genetically susceptible, foetuses, children and elderly people with and without diabetes and / or obesity and regulation of defense mechanisms such as DNA repair. The molecular epidemiology development includes measures of internal dose of environmental factors, dietary interactions, effects in the form of oxidative and chemical stress, thecellular response in the form of gene expression patterns, resulting DNA damageand related repair capacity, genetic susceptibility, cardiovascular functionand aging. Biomarkers of exposure and effects are applied in vulnerablepopulations and validated by the predictive value in relation to diseasedevelopment in large cohorts.

Major recent research achievements include demonstration of effects of nanoparticles on oxidative damage to DNA and vascular functions both in susceptible transgenic animal models and in humans, and that a number of biomarkers of exposure can predict risk of cancer in prospective settings. 

Major grants and research leadership

Coordinator and grant holder of the Center of Excellence Air Pollution in a Life time Health Perspective (AIRPOLIFE) 2004-2010 granted  25 mill. Dkr. from the Danish Research Agency.

Coordinator and grant holder of the research program Health Effects of Air Pollution: Interactions between Oxidative stress and Diet (HEAPOD) 1999-2003 granted 14 mill. DKr. from the program Prevention and Health Promotion via the Research Councils.

Coordinator and grant holder of Center for Environment and Cancer, granted  6 mill. DKr. over 3 years from 2000 from The Environmental Research Center of the Danish Ministry for the Interior and Health

Coordinator of the health part (share 2.5 mill. Dkr. 2000-03) of the program Transport Research Impact on health and environment and Policy financed by the Strategic Environmental Research Program

Partner in ECNIS (Environment Cancer Nutrition and Individual Susceptibility) EU FP6 grant 2005-10; share 2005-2008: 4 mill. DKr.

Partner in ECNIS2 (Environment Cancer Nutrition and Individual Susceptibility) EU F7 grant 2011-13; share 0.6 mill. DKr.

Partner in ENPRA (Risk Assessment of Engineered Nanoparticles) EU FP7 grant 2009-12; share 1.5 mill. DKr.

Partner in NanoImpactNet, EU FP7 coordination and support action.

Partner in NANOKEM from the Working Environment Foundation 2007-10; share 1.3 mill. DKr.

Partner in BIOFUEL and WOODUSE from the Strategic Research Councils 2005-10; share 2 mill. DKr.

Grants from the Research Councils on health and disease 2004 and 2007 in total of 2.4 mill. DKr.

Grants from the Environmental Protection Agency and the Health Ministry 1.1 mill DKr. in 2007.

Partner in CISBO (Center for Indeklima og Sundhed i Boliger) from Realdania, share 2009-2014 5 mill. DKr.

Partner in Center for Pharmaceutical Nanotechnology and Nanotoxicology 2009-2014 share 3.6 mill. DKr.

Partner in Lundbeck Foundation Center for BioMembranes in NanoMedicine 2010-2015 share 3 mill. DKr.

Partner in Danish Nanosafety Center 2012-2015, share 1.8 mill. DKr

Grantholder of Mechanismsof action of adverse effects of nanoparticles at single cell level 2012-2016with 3 mill DKK from the Danish Council for Independent Research in Medical Sciences

10 competitive PhD grants from the Health Science Faculty at University of Copenhagen (2001-2012) corresponding to 15 mill DKr.

Research supervision

Supervisor of 38 (22 main supervisor) ph.d. students through completion, 10 pregraduate students and 10 guest researchers so far. At present main supervisor of 2 and cosupervisor of 1 active ph.d. students. 

Mentor of 13 post.doc. fellows.

Selected mentorships

Mentor of Peter Møller (PhD 1999) from 1999 as post.doc./assistant professor. He achieved a Dr. Med. Sci. in 2005 and was appointed professor in Oxidative Stress in relation to Environment and Health at the Health Science Faculty in 2012

Mentor of Mette Sørensen from pregraduate level in 1998, during a subsequent PhD program and as post.doc. She is now senior researcher at the Danish Cancer Society and has received an ERC grant.

Selected pregraduate teaching

Teaching and course organization related to environmental health at multiple programs, including medicine, at the Faculty of Health Sciences, University of Copenhagen.

Recent cofounder of the new elite masters program in environmental chemistry and health.

Selected administrative experiences

Steffen Loft was chairman of the University of Copenhagen committee for administrative IT until 1998

Steffen Loft has from 2000 to 2015 been Head of Section of Environmental Health, Department of Public Health, Faculty of Health Sciences, University of Copenhagen, with currently around 35 researchers and technicians.

Steffen Loft has completed the University of Copenhagen Leadership Program 2010-2011

Steffen Loft has been on the board of Danish Toxicology Center (ATV Institute), The National Environmental Research Institute and The National Research Center for the Working Environment (Government Research Institutes)

Steffen Loft is from 2015 head of Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen

Selected Public Outreach

Steffen Loft was Chairman 2003-2010, from 2010 member, of the Research Center for Environmental Health of the Danish Ministry for the Interior and Health, now Advisory Scientific Committee on Environmental Health, National Board of Health, Denmark. The committee also maintains an important portal for communication of Environment and Health science (http://miljoogsundhed.sst.dk/english/index.html)

Steffen Loft was Editor-in-Chief (2003-2010) now co-editor of the quarterly Danish science communication journal “Environment and Health” (Miljø og Sundhed) printed in >1000 copies addressed to stakeholders including all the relevant authorities.

Steffen Loft is very frequently used in media regarding environment and health, in particular regarding air pollution and nanoparticles.

International Conferences

Steffen Loft has organized a number of international conferences and workshops and has been invited as speaker and keynote speaker on multiple occasions.

Selected International Science Evaluation

Frequently PhD evaluator in Norway, Sweden and Finland

Grant evaluator in USA, UK, Netherlands, Italy, France, Germany, Norway, Sweden and Finland

Peer reviewer for the leading journals in the relevant fields

Editorial boards 

Nanotoxicology (IF 5.8), Journal of Molecular Medicine (IF 4.7), Archives of Biochemistry and Biophysics (IF 2.9), Basic and Clinical Pharmacology and Toxicology (IF 2.2), Fibers (no IF yet)

Associate Editorship

Particle and Fibre Toxicology – leading journal in toxicology with IF 7.3

Publications

390 scientific papers in international peer-reviewed journals in the field, 19 international book chapters (no 17, 71, 92, 97, 109, 119, 122, 135, 151,158, 161, 179, 193, 226, 232, 237, 256, 296, 308) and 9 publications in the Danish Medical Journal (no 5, 18, 21, 33, 57, 153, 154, 186, 271). The number of citations of the journal papers exceeds 16,000 totally or 4.4 citations per year per paper on average for the more than 200 papers published during the last 15 yr. Average impact factor of international journals published in during the last 3 years is >5. H-index is currently 65 in ISI (3 highly cited  papers are incorrectly registered in ISI) and in Scopus the H-index is 68 and in Google Scolar it is 77.

Complete list of publications for Steffen Loft

1.          Loft S, Jensen V, Rørsgaard S, Dyrberg V. Influence of moderate alcohol intake on thiopental anesthesia. Acta Anaesthesiol Scand 26: 22-26, 1982

2.          Vestergaard Olsen V, Loft S, Christensen KD. Serious reactions during malaria prophylaxis with pyrimethamine sulphadoxine. Lancet 1982 ii: 994

3.          Loft S, Jensen V, Rørsgaard S. Influence of moderate alcohol intake on wakening plasma thiopental concentration. Acta Anaesthesiol Scand 27: 266-269, 1983

4.          Loft S, Willumsen L. Tropical anamnesis disguising malignant lymphoma. Scand J Haematol 31: 168-172, 1983

5.          Christensen KD, Loft S, Vestergaard Olsen V. Alvorlige bivirkninger under anvendelse af sulfadoxin/pyrimetamin (Fansidar). Ugeskr Læger 145: 245-246, 1983

6.          Loft S, Boel J, Kyst A, Rasmussen B, Hansen SH, Døssing M. Increased   micro­somal enzyme activity after surgery under halothane and spinal anesthesia. Anesthesiology 62: 11-16, 1985

7.          Sonne J, Døssing M, Loft S, Andreasen PB. Antipyrine clearance in pneumonia. Clin Pharmacol Ther 37: 701-703, 1985

8.          Loft S, Haxholdt O, Døssing M. Antipyrine clearance in children from single saliva samples. Br J Clin Pharmacol 19: 698-700, 1985

9.          Døssing M, Loft S, Schroeder E. Jet fuel and liver function. Scand J Work Environment Health 11: 433-437, 1985

10.       Loft S, Sonne J, Pilsgaard H, Døssing M, Enghusen Poulsen H. Inhibition of antipyrine elimination by disulfiram and cimetidine: the effect of concomitant administration. Br J Clin Pharmacol 21: 75-77, 1986

11.       Haxholdt O, Loft S, Clemmensen A, Hjortsø E. Increased antipyrine clearance in children after surgery under halothane anaesthesia.  Anaesthesia 41: 579-581, 1986

12.       Loft S, Døssing M, Poulsen HE, Sonne J, Olesen KL, Simonsen K, Andreasen PB. Influence of dose and route of administration on disposition of metronidazole and its major metabolites after intravenous and oral doses of 500 and 2000 mg. Eur J Clin Pharmacol 30: 467-473, 1986

13.       Laybourn C, Tønnesen P, Loft S, Sonne J, Døssing M. Pulmonary disease and antipyrine clearance. Clin Pharmacol Ther 40: 415-419, 1986

14.       Loft S, Poulsen HE, Sonne J, Døssing M, Pedersen KT, Jørgensen BG. Inhibition and induction of metronidazole and antipyrine metabolism. Eur J Clin Pharmacol 32: 35-41, 1987

15.       Loft S, Sonne J, Døssing M, Andreasen PB. Metronidazole pharmacokinetics in patients with hepatic encephalopathy. Scand J Gastroenterol 22: 117-123, 1987

16.       Sonne J, Døssing M, Poulsen HE, Pilsgaard H, Rasmussen B, Loft S. Effect of concomitant administration of cimetidine and phenobarbital on antipyrine elimination. Int J Clin Pharmacol Ther Toxicol 25: 194-196, 1987

17.       Poulsen HE, Loft S. Assessment of quantitative hepatic function: Antipyrine metabolism - an update. Assessment and management of hepatobiliary disease, p. 191-196, 1987

18.       Døsing M, Sonne J, Loft S, Pedersen KT. Virkningen af miljøfaktorer, alder køn og menstruationscyklus på leverens lægemiddelomsætning. Ugeskr f læg 149: 2201-2204, 1987

19.       Loft S, Ewald T, Simonsen K, Christensen H, Sonne J, Døssing M. Influence of prednisolone on antipyrine elimination in patients with obstructive lung disease. Eur J Clin Pharmacol 33: 89-91, 1987

20.       Loft S, Olesen KL, Døssing M. Increased susceptibility to liver disease in relation to alcohol consumption in women. Scand J Gastroenterol 22: 1251-1256, 1987

21.       Sonne J, Døssing M, Loft S. Sygdom og hepatisk lægemiddelomsætning. Ugeskr f læg 150: 204-209, 1988

22.       Døssing M, Loft S, Sonne J, Schroeder E. Antipyrine and metronidazole metabolism during occupational exposure to gasoline. Int Arch Occup Envir Health 60: 115-118, 1988

23.       Loft S, Døssing M, Sonne J, Poulsen HE. Metronidazole clearance: A one-sample method and influencing factors. Clin Pharmacol Ther 43: 420-428, 1988

24.       Poulsen HE, Loft S. Antipyrine as model drug to study hepatic drug metabolism capacity in man. J Hepatol: 6: 374-382, 1988

25.       Sonne J, Loft S, Døssing M, Volmer-Larsen A, Olesen K-L, Victor MA.  Bioavailability and pharmacokinetics of oxazepam. Eur J Clin Pharmacol 35: 385-389, 1988

26.       Sonne J, Poulsen HE, Loft S, Døssing M, Volmer-Larsen A, Simonsen K, Thyssen H. Therapeutic doses of codeine have no effect on acetaminophen clearance or metabolism. Eur J Clin Pharmacol 35: 109-111, 1988

27.       Loft S, Døssing M, Poulsen HE. Influence of age and consumption of tobacco alcohol and caffeine on antipyrine clearance. Human Toxicol 7: 277-280, 1988

28.       Loft S, Døssing M, Sonne J, Dalhoff K, Bjerrum K, Poulsen HE. Lack of effect of cimetidine on the metabolism of metronidazole in man. Eur J Clin Pharmacol 35: 65-68, 1988

29.       Larsen M, Loft S, Hommel E, Lund-Andersen H. Fluorescein and fluorescein monoglucuronide in plasma after intravenous injection of fluorescein. Acta Ophtalmologica Scand 66: 427-432, 1988

30.       Sonne J, Dragsted J, Loft S, Døssing M, Andreasen F. The influence of a very low-calorie diet on the clearance of oxazepam and antipyrine in humans. Eur J Clin Pharmacol 36: 407-409, 1989

31.       Loft S, Poulsen HE. Metronidazole and antipyrine metabolism in isolated rat hepatocytes: Influence of sex and enzyme induction and inhibition. Biochem Pharmacol 38, 1125-36, 1989

32.       Tvede KG, Loft S, Poulsen HE, Schou JS. Methyl parathion toxicity in rats is changed by pretreatment with the pesticides chlordecone, mirex and linuron.  Archives of Toxicology Suppl 13: 446-447, 1989

33.       Ott P, Hansen PB, Dalhof K, Loft S, Poulsen HE, Analgetikaforbrug, -overdosering og -dødsfald i Danmark 1979-1986. Ugeskr f læg 152: 250-252, 1990

34.       Sonne J, Døssing M, Loft S, Olesen KL, Vollmer-Larsen A, Victor MA, Hamberg O, Thyssen H. Single dose pharmacokinetics and pharmacodynamics of oral oxazepam during concomitant administration of propanolol and labetalol. Br J Clin Pharmacol 29, 33-37, 1990

35.       Loft S, Poulsen. Metabolism of metronidazole and antipyrine in hepatocytes isolated from mouse and rat. Xenobiotica 20, 185-191, 1990

36.       Hinson JA, Roberts DW, Benson RW, Dalhoff K, Loft S, HE Poulsen.  Mechanism of paracetamol toxicity.  Lancet 335, 732, 1990

37.       Loft S.  Metronidazole and antipyrine as probes for the study of foreign compound metabolism.  Pharmacol Toxicol 66, suppl. VI, 1-31, 1990

38.       Hamberg O, Ovesen L, Dorfeldt A, Loft S, Sonne J. The effect of dietary energy and protein deficiency on drug metabolism.  Eur J Clin Pharmacol 38, 567-570, 1990

39.       Ott P, Dalhoff K, Hansen PB, Loft S, Poulsen HE. Consumption, overdose and death from analgesics in a period with over-the-counter release of paracetamol in Denmark. J Int Med 227, 423-428, 1990

40.       Loft S, Egsmose C, Sonne J, Poulsen HE, Døssing M, Andreasen PB. Metronidazole elimination is preserved in the elderly, Hum Toxicol 9, 155-161, 1990

41.       Sonne J, Andreasen PB, Loft S, Døssing M, Andreasen F.  Glucuronidation of oxazepam is not spared in patients with alcoholic cirrhosis and hepatic encephalopathy. Hepatology 11, 951-956, 1990

42.       Loft S, HE Poulsen. Prediction of xenobiotic metabolism by non-invasive methods.  Pharmacol Toxicol 67, 101-108, 1990

43.       Sonne J, Boesgaard S, Poulsen HE, Loft S, Hansen JM, Døssing M, Andreasen F.  Pharmacokinetics and pharmacodynamics of oxazepam and paracetamol in severe hypothyroidism.  Br J Clin Pharmacol 30, 732-742, 1990

44.       Loft S, Nielsen AJ, Borg BE, Poulsen HE. Metronidazole and antipyrine metabolism in the rat: Clearance determination from one saliva sample.  Xenobiotica 21, 33-46, 1991

45.       Vistisen K, Loft S, Poulsen HE.  Cytochrome P450 IA2 activity in man measured by caffeine metabolism: effect of smoking, broccoli and exercise.  Adv Exp Med Biol 283, 407-411

46.       Loft S, Otton SV, Lennard ML, Tucker GT, Poulsen HE: Characterization of metronidazole metabolism by human liver microsomes. Biochem Pharmacol 41, 1127-1134, 1991

47.       Sonne J, Loft S, Døssing M, Boesgaard S, Andreasen F.  Single dose pharmacokinetics and pharmacodynamics in very elderly institutionalised subjects.  Br J Clin Pharmacol 31, 719-722, 1991

48.       Sjovald S, Ahren B, Hansson P, Loft S, Poulsen HE, Bengmark S: Metabolic responses to intermittent hepatic deterialization in the rat. J Hepatol 13, 33-37, 1991

49.       Dalhoff K, Hansen PB, Ott P, Loft S, Poulsen HE.  Acute ethanol administration reduces the antidote effect of N-acetylcysteine after acetaminophen overdose in mice.  Hum Exp Toxicol 10, 431-433, 1991

50.       Sherson D, Sigsgaard T, Overgaard E, Loft S, Poulsen HE, Jongeneelen FJ:  Interaction of smoking, uptake of polyaromatic hydrocarbons and cytochrome P450IA2 activity among foundry workers.  Br J Ind Med 49, 197-202, 1992

51.       Fischer-Nielsen A, Poulsen HE, Loft S. 8-hydroxydeoxyguanosine in vitro: effects of glutathione, ascorbate and 5-aminosalicylic acid. Free Rad Biol Med 13, 121-126, 1992

52.       Vistisen K, Poulsen HE, Loft S: Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine. Carcinogenesis 13, 1561-1568, 1992

53.       Poulsen HE, Loft S, Andersen M, Andersen JR. Disulfiram therapy - adverse reactions and interactions. Acta Psyc Scand 86, suppl. 369, 1992

54.       Loft S, Vistisen K, Ewertz M, Tjønneland A, Overvad K, Poulsen HE: Oxidative DNA-damage estimated by 8-hydroxydeoxyguanosine excretion in humans: influence of smoking, gender and body mass index. Carcinogenesis 13, 2241-2247, 1992

55.       Loft S, Otte J, Poulsen HE, Sørensen H: Influence of indolyl glucosinolates (¿myrosinases) on the in vivo metabolism of metronidazole and antipyrine in the rat. Food Chem Toxicol 30, 927-935, 1992

56.       Poulsen HE, Loft S, Wasserman K. Cancer risk related to genetic polymorphisms in carcinogen metabolism and DNA repair. Pharmacol Toxicol 72: suppl I, 93-103, 1993

57.       Sherson D, Sigsgaard TI, Overgaard E, Loft S, Poulsen HE, Jongeneelen FC. Lungecancerrisici blandt støberiarbejdere. Ugeskr Læger 155: 620-623, 1993

58.       Jensen KG, Loft S, Doehmer J, Poulsen HE. Metabolism of phenacetin in V79 Chinese hamster cell cultures expressing rat liver CYP1A2 compared to isolated rat hepatocytes. Biochem Pharmacol 45: 1171-1173, 1993

59.       Brøsen K, Skjelbo E, Rasmussen BB, Poulsen HE, Loft S. Fluvoxamine is a potent inhibitor of cytochrome P4501A2. Biochem Pharmacol 45: 1211-1214, 1993

60.       Boesgaard S, Poulsen HE, Aldershvile J, Loft S, Anderson ME, Meister A: Acute effects of nitroglycerine depend on both plasma and intracellular sulhydryl compound levels in vivo. Effect of agents with different sulfhydryl modulating properties. Circulation 87: 547-553, 1993

61.       Jeding E, Loft S, Poulsen HE. No induction of extrahepatic antipyrine and metronidazole metabolism evaluated from partially hepatectomized rats. Xenobiotica 23: 411-418, 1993

62.       Loft S, Fischer-Nielsen A, Jeding IB, Vistisen K, Poulsen HE. 8-Hydroxydeoxyguanosi­ne as a Urinary Biomarker of Oxidative DNA-damage. J Toxicol Environ Health 40: 397-410

63.       Ranek L, Dalhoff K, Poulsen HE, Brøsen K, Flachs H, Loft S, Wantzin P. Drug metabolism in subjects with previous halothane hepatitis. Scand J Gastroenterol 28: 677-680, 1993,

64.       Jensen KG, Önfelt A, Poulsen HE, Döhmer J, Loft S. Effects of Benzo[a]pyrene and (¿)-trans-7,8-dihydroxy-7,8,dihydrobenzo[a]pyrene on mitosis in Chinese hamster V79 cells with stable expression of rat cytochrome P4501A1 or 1A2. Carcinogenesis 14: 2115-2118, 1993

65.       Ding JW, Anderson R, Soltesz V, Willén R,  Loft S, Poulsen HE, Pärsson H, Olsson K, Bengmark S. The effect of billiary decompression on bacterial translocation in jaundiced rats. Hepatobiliary Surgery 7: 99-110, 1993

66.       Fischer-Nielsen AF, Loft S, Jensen KG. Effect of ascorbate and 5-aminosalicylic acid on light induced 8-hydroxydeoxyguanosine formation in V79 Chinese hamster cells. Carcinogenesis 14: 2431-2433, 1993

67.       Poulsen HE, Loft S. The impact of genetic polymorphisms in risk assessemnt of drugs. Arch Toxicol suppl. 16: 211-222, 1994

68.       Boesgaard S, Aldershvile J, Poulsen HE, Loft S, Anderson ME, Meister A. Nitrate tolerance in vivo is not associated with depletion of arterial or venous thiol levels. Circ Res 74: 115-120, 1994

69.       Loft S, Astrup A, Bueman B, Poulsen HE. Oxidative DNA damage correlates with oxygen consumption in humans. FASEB J 8: 534-537, 1994

70.       Fischer-Nielsen A, Jeding IB, Loft S. Radiation induced formation of 8-hydroxy-2'-deoxyguanosine and its prevention by scavengers, Carcinogenesis 15: 1609-1612, 1994

71.       Poulsen HE, Lykkesfeldt J, Loft S. The oxidant and antioxidant functions of oestrogens. HRT's imact on menopausal changes. p. 91-102. Wells Medical Limited, 1994.

72.       Lykkesfeldt J,  Loft S, Poulsen HE.Simultaneous determination of urinary free cortisol and 6ßhydroxycortisol by high-performance liquid chromatography as a measurement of human CYP3A activity. J Chromatogr 660: 23-29, 1994

73.       Loft S, Larsen PN, Rasmussen A, Fischer-Nielsen A, Bondesen S, Kirkegaard P, Rasmussen LS, Ejlersen E, Tornøe K, Bergholdt R, Poulsen HE. Oxidative DNA damage after transplantation of the liver and small intestine in pigs. Transplantation 59: 16-20, 1995

74.       Rasmussen BB, Mäenpää J, Pelkonen O, Loft S, Poulsen HE, Lykkesfeldt J, Brøsen K. Selective serotonin reuptake inhibitors and theophylline metabolism in human liver microsomes: potent inhibition by fluvoxamine. Br J Clin Pharmacol 39: 151-159, 1995

75.       van Poppel G, Poulsen HE, Loft S, Verhagen H. No influence of beta-carotene on oxidaitve DNA damage in male smokers. J Natl Cancer Inst 87: 310-311, 1995

76.       Jensen KG, Poulsen HE, Doehmer J, Loft S. Kinetics and inhibition by fluvoxamine of phenacetin O-deethylation in V79 cells expressing human CYP1A2. Pharmacol Toxicol 76: 286-288, 1995

77.       Nielsen HB, Hanel B, Loft S, Poulsen HE, Pedersen BK, Diamant M, Vistisen K, Secher NH. Restricted pulmonary diffusion capacity after exercise is not an ARDS-like injury. J Sports Sciences 13: 109-113, 1995

78.       Verhagen H, Poulsen HE, Loft S, van Poppel G, Willems MI, van Bladeren PJ. Reduction of oxidative DNA damage in man by Brussels sprouts. Carcinogenesis 16: 969-970, 1995

79.       Fischer-Nielsen A, Corcoran GB, Poulsen HE, Kamandulis LM, Loft S. Menadione-induced DNA fragmentation without 8-oxo-7,8-dihydro-2'-deoxyguanosine formation in isolated rat hepatocytes. Biochem Pharmacol 49: 1469-1474, 1995

80.       Loft S, Velthuis-te Wierik EJM, van der Berg H, Poulsen HE. Energy restriction and oxidative DNA damage in humans. Cancer Epidemiology Biomarkers & Prevention 4: 515-519, 1995

81.       Poulsen HE, Loft S. Early biochemical markers of effect: enzyme induction, oncogene activation and markers of oxidative damage. Toxicology 101: 55-64, 1995

82.       Thomsen M, Loft S, Roberts D, Poulsen HE. CYP2E1 inhibition by propylene glycol prevents acetaminophen (paracetamol) hepatotoxicity in mice without CYP1A2 inhibition. Pharmacol Toxicol 76:286-8 1995

83.       Lykkesfeldt J, Loft S, Poulsen HE. Determination of ascorbic acid and dehydroascorbic acid in plasma by high-performance liquid chromatography with coulometric detection - a reliable biomarker of oxidative stress ? Analytical Chemistry 229: 329-335, 1995

84.       Velthuis-te Wierik EJM, van Leeuwen R, Hendriks HFJ, Verhagen H, Loft S,  Poulsen HE, van der Berg H. Moderate energy restriction does not affect parameters of oxidative stress and genotoxicity in humans. J Nutr 125: 2631-2639, 1995.

85.       Jensen KG, Poulsen HE, Doehmer J, Loft S. Paracetamol induced spindel disturbances in V79 cells with and without expression of human CYP1A2. Pharmacol Toxicol, 78: 224-228, 1996

86.       Tuo J, Loft S, Thomsen M, Poulsen HE. Ex vivo time-dependent cell-DNA-degradation shown by single cell gel electrophoresis. Pharmacol Toxicol 78: 55-57, 1996

87.       Loft S, Poulsen HE. Cancer risk and oxidative DNA damage in man. J Mol Med 74: 297-312, 1996

88.       Lykkesfeldt J, Prieme H, Loft S, Poulsen HE. Effect of smoking cessation on plasma ascorbic acid . Br Med J 313: 91, 1996

89.       Poulsen HE, Loft S, Vistisen K. Extreme exercise and oxidative DNA modification. J Sports Med 14: 343-346, 1996

90.       Jeppesen U, Gram LF, Vistisen K,  Loft S, Poulsen HE, Brosen K. Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine. Eur J Clin Pharmacol 51: 73-78, 1996

91.       Tuo J, Loft S, Thomsen M, Poulsen HE. Benzene induced genotoxicity in mice in vivo detected by the comet assay: reduction by CYP2E1 inhibition. Mutation Res 368: 213-219, 1996

92.       Prieme H, Loft S, Cutler RG, Poulsen HE. Measurement of oxidative DNA injury in humans: evaluation of a comercially available ELISA assay.  s. 78-82 i Natural Antioxidants & Food Quality in Atherosclerosis and Cancer Prevention. The Royal Society of Chemistry 1996.

93.       Jeppesen U, Loft S, Poulsen HE, Brosen K. A fluvoxamine-caffeine interaction study. Pharmacogenetics 6: 213-222, 1996

94.       Loft S, Jensen KG, Ringby L-L, PoulsenHE, Doehmer J. Kinetic Studies in Engineered V79 Cells in Comparison with Primary Hepatocytes and Human Liver Microsomes. Exp Toxicol Pathol 48 suppl. II: 249-255, 1996

95.       Prieme H, Loft S,  Nyyssönen K, Salonen JT, Poulsen HE. No effect of supplementation with vitamin E, ascorbic acid or coenzyme Q10  in humans on oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2'-deoxyguanosine. Am J Clin Nutr 65: 503-507, 1997

96.       Vistisen K, Priemé H, Okkels H, Vallentin S, Loft S, Olsen JH, Poulsen HE. Genotype and phenotype of glutathione S-transferase µ in testicular cancer. Pharmacogenetics 7: 21-25, 1997

97.       Poulsen HE, Loft S, Prieme H, Salonen J. Antioxidants. In Haunsø S, Aldershvile J, Svendsen JH eds. Coronary Microcirculation during Ischaemia and Reperfusion. Alfred Benzon Symposium 41: 455-461, 1997

98.       Lykkesfeldt J, Loft S, Nielsen JB, Andersen HR, Poulsen HE. Ascorbic acid and dehydroascorbic acid as biomarkers of oxidative stress caused by smoking. Am J Clin Nutrition 65: 503-507, 1997.

99.       Deng X-S, Tuo J, Poulsen HE, Loft S. 2-Nitropropane induced DNA Damage in Rat Bone Marrow. Mutation Res 391: 165-169, 1997

100.   Klarlund M, Prieme H,  Loft S, Poulsen HE. Smoking cessation dose not change urinary albumin excretion in normal subjects. Scand J Clin Lab Invest 57: 513-520, 1997

101.   Cadenas S, Barja G, Poulsen HE, Loft S. Oxidative DNA Damage Estimated by oxo⁸dG in the Liver of Guinea Pigs Supplemented with Graded Dietary Doses of Ascorbic Acid and a-Tocopherol. Carcinogenesis 18: 2373-2377, 1997

102.   Prieme H,  Loft S,  Klarlund M, Grønbæk K,Tønnesen P, Poulsen HE. Effect of smoking cessation on oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion. Carcinogenenesis¨19: 347-351, 1998.

103.   Poulsen HE, Prieme H, Loft S. Role of oxidative DNA damage in cancer initiation and promotion. Eur J Cancer Prevent 7: 9-16, 1998.

104.   Prieme H, Nyyssönen K, Grønbæk K, Klarlund M, Loft S, Tønnesen P, Salonen JT, Poulsen HE. Randomized controlled smoking cessation study: transient increase in plasma high density lipoprotein but no change in lipoprotein oxidation resistance. Scand J  Clin Lab Invest 58:11-18, 1998

105.   Loft S, Poulsen HE. Estimation of oxidative DNA damage in man from urinary excretion of repair products. Acta Biochimica Polonica 45: 133-144, 1998

106.   Deng X-S, Tuo J, Poulsen HE, Loft S. Prevention of oxidative DNA damage by Brussels sprouts in rats. Free Rad Res 28: 323-333, 1998.

107.   Tuo J, Wolff SP, Loft S, Poulsen HE. Formation of nitrated and hydroxylated aromatic compounds from benzene and peroxynitrite, a possible mechanism of berzene genotoxicity. Free Radical Res 28: 369-375, 1998

108.   Poulsen HE, Weimann A, Salonen J, Loft S, Cadet J, Douki T, Ravanat J-L Does vitamin C have a pro-oxidant effect. Nature 395: 231-232, 1998

109.   Loft S, Poulsen HE. Measurement of oxidative damage to DNA: interpretation of nuclear levels and urinary excretion of repair products in DNA damage and Repair: Oxygen Radical Effects, Cellular Protection and Biological Consequences. M. Dizdaroglu, Karyaka, Ed. NATO ASI Series pp. 267-281. Plenum Press, New York 1998

110.   Loft S, Deng X-S, Tuo J, Wellejus A, Sørensen M, Poulsen. Experimental study of oxidative DNA damage. Free Rad Res 29: 525-539, 1998

111.   Poulsen H, Loft S, Prieme H, Vistisen K, Lykkesfeldt J, Nyyssonen K, Salonen JT Oxidative DNA damage in vivo, interpretation, relation to age, plasma antioxidants, drug metabolism, glutathione-S-transferase activity and urinary creatinine correction. Free Rad Res 29: 565-571, 1998

112.   Loft S, E. B. Thorling, H. E. Poulsen. High fat diet induced oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2'-deoxyguano­sine excretion in rats. Free Rad Res 29: 595-600, 1998

113.   Haderslev KV.  Sonne J.  Poulsen HE.  Loft S. Paracetamol metabolism in patients with ulcerative colitis. Br J Clin Pharmacol  46: 513-6, 1998

114.   Tuo J,  Deng X-S, Loft S, Poulsen HE. Dexamethasone ameliorates oxidative DNA damage induced by benzene and LPS in mouse bone marrow.  Free Rad Res 30: 29-36, 1999

115.   Loft S, Poulsen HE. Markers of oxidative damage to DNA - antioxidants and molecular damage. Meth Enzymol 300: 166-184, 1999

116.   Autrup H, Daneshvar B, Dragsted LO, Gamborg M, Hansen ÅM, Loft S, Okkels H, Nielsen F, Nielsen PS, Raffn E, Wallin H, Knudsen LE. Biomarkers for exposure to ambient air pollution – comparison of carcinogen adduct levels with other exposure markers and markers for oxidative stress. Environ Health Perspec 107: 233-238, 1999

117.   Loft S, Poulsen HE, Vistisen K, Knudsen LE. Increased excretion of 8-oxo-7,8-dihydro-deoxyguanosine, a biomarker of oxidative DNA damage, in urban bus drivers. Mutation Res 441: 11-19, 1999

118.   Tuo J,  Loft S, Poulsen HE. Enhanced benzene-induced DNA damage in PMA stimulated cells in vitro and LPS treated animals. Free Rad Biol Med 26: 801-808, 1999

119.   Poulsen HE, Prieme H, Loft S. Interpretation of oxidative DNA modification: relation between tissue levels, excretion of urinary repair products and single cell gel electrophoresis (comet assay). in DNA and Free Radicals: Techniques, Mechanisms & Applications. Eds Aruoma OI & Halliwell B. pp. 262-270,1999.

120.   Poulsen HE, Weimann A, Loft S. Methods to detect DNA damage by free radicals, relation to exercise. Proc Nutr Soc 58. 1-7, 1999

121.   Wellejus A, Poulsen HE, Loft S. Iron overload induces oxidative DNA damage in rat sperm cells. Free Rad Res 32: 75-83, 2000

122.   Poulsen HE, Loft S, Weimann A. Urinary measurement of 8-oxodG (8-oxo-2’-deoxyguanosine). in Measuring in vivo oxidative damage: a practical approach. Eds Griffiths H & Lunec J. Jon Wiley & Sons Ltd, Chichester UK 2000, pp. 69-80.

123.   Sørensen M, Loft S. No significant paraquat-induced oxidative DNA damage in rats. Free Rad Res, 32: 423-428, 2000

124.   Zhu C, Poulsen HE, Loft S. Inhibition of Oxidative DNA Damage In Vitro by extracts of Brussels Sprouts. Free Radical Res 33: 187-196, 2000

125.   Collins AR, Brown J, Bogdanov M, Cadet J, Cooke M, Douki T, Dunster C, Eakins J, Epe B, Evans M, Farmer P, Gedik CM, Halliwell B, Herbert K, Hofer T, Hutchinson R, Jenner A, Jones GDD, Kasai H, Kelly F, Lloret A, Loft S, Lunec J, McEwan M, Moller L, Olinski R, Podmore I, Poulsen H, Ravanat JL, Rees JF, Reetz F, Shertzer H, Spiegelhalder B, Turesky R, Tyrrell R, Vina J, Vinicombe D, Weimann A, de Wergifosse B, Wood SG. Comparison of different methods of measuring 8-oxoguanine as a marker of oxidative DNA damage. Free Radical Res 32: 333-341, 2000

126.   Salonen JT, Porkkala-Sarataho E Nyyssönen K, Kaikkonen J,  Salonen R, Ristonmaa U, Diczfalusy U, Brigelius-Flohe R, Loft S, Poulsen HE. Long-term effects of vitamin E, vitamin C and combination supplementation on urinary 8-oxodeoxyguanosine, cholesterol oxidation products and oxidation resistance of lipids in non-depleted men. Arteriosclerosis, Thrombosis, and Vascular Biology. 20: 2087-2093, 2000

127.   Tuo J, Liu L, Poulsen HE, Weimann A, Svendsen, Loft  S. Importance of guanine nitration and hydroxylation in DNA in vitro and in vivo. Free Radical Biol Med 29: 147-155, 2000

128.   Møller P, Knudsen LE, Loft S, Wallin H. The comet assay as a rapid test in biomonitoring occupational exposure to DNA damaging agents and effect of confounding factors. Cancer Epidemiol Biomarkers Prev 9:1005-1015, 2000

129.   Loft S, Poulsen HE. Antioxidant intervention studies related to DNA Damage, DNA repair and gene expression. Free Radical Res 33: S67-83, 2000

130.   Poulsen HE, Jensen BR, Weimann A, Jensen SA, Sørensen M, Loft S. Antioxidants, DNA damage and gene expression. Free Radical Res 33: S33-40, 2000

131.   Kruse P, Anderson M, Loft S. Minimum signs of oxidative stress during acute pancreatitis in rats. Free Radical Biol Med 30:309-317, 2001

132.   Hertel O, Solvang Jensen S, Andersen HV, Palmgren F,  Wåhlin P, Skov H, Nielsen IV, Sørensen M,  Loft S, Raaschou-Nielsen O. Human exposure to traffic pollution. Experience from Danish studies. Pure Appl Chem 73 137-145, 2001

133.   M Sørensen, BR Jensen, HE Poulsen, X-S Deng, N Tygstrup, K Dalhoff, S Loft. Increase in oxidative DNA damage after administration of a Brussels sprouts extract. Food Chem Toxicol 39: 533-540, 2001

134.   P Møller, C Lundby, S Loft, NV Olsen. Acute hypoxia and hypoxic exercise induces DNA strand breaks and oxidative DNA damage in humans. FASEB J 15: 1181-86, 2001

135.   LO Dragsted, JF Young, S Loft, B Sandström. Biomarkers of oxidative stress and of antioxidative defence: relationship to intervention with antioxidant-rich foods. in Micornutrients and Health: Molecular Biological Mechanisms. Eds. K Nesaretnam, L Packer. AOCS Press, Champaign, IL, USA, 2001. pp. 272-278.

136.   Z Chunying, S Loft. Brussels Sprouts Extracts and Induction of Oxidative DNA Damage in Human Lymphocytes. Food Chem Res 39: 533-40, 2001

137.   LE Knudsen, S Loft, H Autrup. Risk assessment, the importance of genetic polymorphisms in man. Mutation Res, 482: 83-8, 2001

138.   A Wellejus, S Loft. Receptor-Mediated 17a-Ethynylestradiol-Induced Oxidative DNA Damage in Rat Testicular Cells.  FASEB J 16: 195-201, 2002

139.   S Vestergaard, S Loft, P Møller. Role of inducible nitrogen oxide synthase in benzene-induced oxidative DNA damage in the bone marrow of mice. Free Rad Biol Med 32:481-484, 2002

140.   Young JF, Dragsted LO, Haraldsdóttir J, Daneshvar B,  Kall MA, Loft S, Nilsson L, Rasmussen SE,  Mayer B, Lauridsen ST, Huynh-Ba T, Hermetter A, Sandström B. Green tea extract only affects markers of oxidative status postprandially. Br J Nutr 87: 343-355, 2002

141.   Collins AR, Gedik CM, Wood S, White A, Bubois J, Duez P, Rees JF, Legall R, Degand L, Loft S, Jensen A, Poulsen H, Weimann A, Jensen BR, Cadet, J, Douki T, Ravanat JL, Faure H, Tripier M, Morel I, Sergent O, Cillard P, Morin B, Epe B, Phoa N, Hartwig A, Pelzer A, Dolara P, Casalini C, Guglielmi F, Luceri C, Kasai H, Kido R, Olinski R, Bialkowski K, Duracková Z, Hlincikova L, Korytar P, Dusinska M, Mislanova C, Vina J, Lloret A, Möller L, Hofer T, Gremaud E, Fay L, Stadler R, Eakins J, Pogna F, O’Brien J, Elliott R, Astley S, Bailley A, Herbet K, Chauhan D, Kelly F, Dunster C, Lunec J, Podmore I, Patel P, Johnson S, Evans M, White A, Tyrrell R. Inter-laboratory validation of procedures for measuring  8-oxo-7,8-dihydrooxoguanine/8-oxo-7,8-dihydro-2’-deoxyguanosine. Free Radical Res 36: 239-245, 2002

142.   G Jürgens, HR Christensen, K Brøsen, J Sonne, S Loft, NV Olsen. Acute hypoxia and cytochorme P450-mediated hepatic drug metabolism in humans. Clin Pharmacol Ther 71: 214-221, 2002

143.   A Wellejus, M Dalgaard, S Loft. Oxidative DNA damage in male Wistar rats exposed to dibutylphthalate.. J Toxicol Environ Health A 65: 813-24 2002

144.   Griffiths HR, Møller L, Bartosz G, Bast A, Bertoni-Freddari C, Collins A, Coolen S, Haenen G, Loft S, Lunec J, Olinski O, Parry J, Pompella A, Poulsen HE, Verhagen H. Biomarkers. Mol Asp Med 23: 101-208, 2002

145.   P Møller, S Loft. Oxidative DNA damage in white blood cells of humans in dietary antioxidant supplementation studies. Am J Clin Nutr 76: 303-310, 2002

146.   Dragsted, L.O., Daneshvar, B., Vogel U., Autrup, H.N., Wallin H., Risom, L., Møller., P., Mølck, A.M., Hansen, M., Poulsen, H.E., Loft, S. A sucrose-rich diet increases mutation in the rat colon, Cancer Res 62: 4339-4346, 2002

147.   P Møller, H Wallin, U Vogel, H Autrup, L Risom, B Daneshvar, LO Dragsted, HE Poulsen, S Loft Genotoxicity and mutagenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in colon and liver of Big Blue™ rats: role of DNA adducts, strand breakage, DNA repair and oxidative  damage, Carcinogenesis 23: 1379-1385, 2002

148.   Besaratinia A, Maas LM, Brouwer EMC, Moonen EJC, De Kok TMCM, Loft S, Kleinjans JCS, Van Schooten FJ. A molecular dosimetry approach to assess human exposure to environmental tobacco smoke in pubs. Carcinogenesis 23: 1171-1176, 2002

149.   B Riis, L Risom, S Loft, and HE Poulsen Increased OGG1 expression without increased incision activity and changes in 8-oxodeoxyguanosine levels after partial hepatectomy. DNA Repair 1: 419-424, 2002

150.   B Riis, L Risom, S Loft, and HE Poulsen. Foetal levels of OGG1 expression and incision activity in rats are higher than in adult rats while 8-oxo-2’-deoxyguanosine levels are unchanged. DNA Repair 1: 709-717, 2002

151.   Loft S, Møller P, Sørensen M, Poulsen HE. Oxidative damage to DNA – human studies. Chemicals in the 21^st Century. Proceedings of the Fourth Princess Chulabhorn International Science Congress, p 199-207, 2002.

152.   U Vogel, P Møller, L Dragsted, S Loft, A Pedersen, B Sandström Inter-individual variation, seasonal variation and close correlation of OGG1 and ERCC1 mRNA levels in full blood from healthy volunteers. Carcinogenesis 23:1505-1509, 2002

153.   M-L Vrang, O Hertel, F Palmgren, P Wåhlin, O Raaschou-Nielsen, S Loft. Helbredseffekter af trafikgenererede ultrafine partikler. Ugeskrift f Læg 34: 3937-41, 2002

154.   Raaschou-Nielsen, F Palmgren, S Solvang Jensen, P Wåhlin, R Berkowicz, O Hertel, M-L Vrang,  S Loft. Helbredseffekter af partikulær luftforurening i Danmark – et forsøg på kvantificering.. Ugeskrift f Læg 34: 3959-3963, 2002

155.   J Bornholdt, M Dybdahl, U Vogel, LO Dragsted, S Loft,  H Wallin. Inhalation of ozone induces DNA strand breaks and inflammation in mice, Mutation Res 520: 63-68, 2002

156.   A Collins, C Gedik, N Vaughan, S Wood, A White , J Dubois, P Duez, D Gilles, B Martine, J-F Rees, S Loft, P. Møller, H Poulsen, B Riis Jensen, A Weimann, J Cadet, T Douki, J-L Ravanat, S Sauvaigo, H Faure, Isabelle Morel, B Morin,  B Epe, N Phoa,  A Hartwig, P Dolara, C Casalini, L Giovannelli, M Lodovici, R Olinski, K Bialkowski, M Foksinski, D Gackowski, Z Durakov, L Hlinikov, P Korytar, M Sivonov, M Dušinská, C Mislanov, J Viña, A Lloret, L Möller, T Hofer, J Nygren, E Gremaud, K Herbert, J Lunec, M Cooke, M, P Patel, I Podmore, A White , C Wild, L Hardie, J Olliver, E.Comparative analysis of baseline 8-oxo-7,8-dihydroguanine in mammalian cell DNA, by different methods in different laboratories: an approach to consensus. Carcinogenesis 23: 2129-2133, 2002

157.   Sørensen M, Dragsted LO, Hertel O, Knudsen LE, Loft S. Personal PM_2.5 exposure and markers of oxidative stress in blood, Environ Health Perspectives 111:161-6, 2003

158.   Loft S, Vogel U, Risom L, Møller P, Riis B, Poulsen HE, Wallin H. Oxidative DNA damage and expression of DNA repair enzymes. XI Biennial Meeting of the Society for Free Radical Research International. Monduzzi Editore, Bologna, 2003, p. 747-755.

159.   Zhu C and Loft S. Effect of chemopreventive compounds from Brassica vegetables on NAD(P)H: Quinone Reductase and induction of DNA strand breaks in murine hepa 1c1c7 cells. Food Chem Toxicol 41: 455-462, 2003

160.   Sørensen M, Autrup H, Hertel O, Wallin H, Knudsen LE, Loft S. Personal exposure to PM_2.5 in an urban environment and biomarkers of genotoxicity. Cancer Epidemiol Biomarkers Prev 12: 191-196, 2003

161.   HE Poulsen, S Loft, BR Jensen, M Sørensen A Weimann. HPLC-ECD, HPLC-MS/MS (Urinary Biomarkers). in Oxidative Stress and Aging – Advances in Basic Science, Diagnostics and Intervention Eds. RG Cutler and H Rodriques. World Scientific Publishing Company, Singapore 2003. pp 233-256.

162.   Collins A,  Gedik C, Vaughan N, Wood S, White A; Dubois J, Duez P, Dehon G, Rees JF, Loft S, Møller P, Poulsen H, Riis B, Weimann A, Cadet J, Douki T, Ravanat JL, Sauvaigo S, Faure H, Morel I, Morin B, Epe B, Phoa N, Hartwig A, Schwerdtle T, Dolara P, Giovannelli L, Lodovici M, Olinski R, Bialkowski K, Foksinski M, Gackowski D, Duracková Z, Hlinciková L, Korytar P, Sivonová M, Dušinská M, Mislanová C , Viña J, Lloret A, Möller L, Hofer T, Nygren J, Gremaud E, Herbert K, Chauhan D, Lunec J, Cooke M, Evans M, Patel P, Podmore I, White A, Wild C, Hardie L, Olliver J, Smith E. Measurement of DNA oxidation in human cells by chromatographic and enzymic methods. Free Radicals Biol Med 34: 1089-1099, 2003

163.   M Sørensen, H Skov, H Autrup, O Hertel, S Loft.Urban Benzene Exposure and Oxidative DNA Damage. Sci Total Environ 309: 69-80, 2003

164.   P Møller, B Daneshvar, S Loft, H Wallin, HE. Poulsen, H Autrup, LO Dragsted. Oxidative DNA damage in vitamin C supplemented guinea pigs after intratracheal instillation of diesel exhaust particles. Toxicol Appl Pharmacol 189: 39-44, 2003

165.   Loft S, Kold-Jensen T, Hjøllund NH, Giwercman A, Gyllemborg J, Ernst E, Olsen J, Scheike T, Poulsen HE,  Bonde JP. Oxidative DNA damage in human sperm influences time to pregnancy. Human Reproduction 18: 1265-1272, 2003

166.   P Møller, Hansen M, Autrup A, Bornholt J, U Vogel, H Autrup, Mølck AM, H Wallin, LO Dragsted, HE Poulsen, S Loft. Dietary low-dose sucrose modulation of IQ-induced genotoxicity in the colon and liver of BigBlue^TM rats. Muation Res 527: 91-7, 2003

167.   Olsen A, Tjønneland A, Thomsen B, Loft S, Stripp C, Overvad K, Møller S, Ewertz, Olsen JH. Fruits, vegetables and risk of breast cancer among postmenopausal women according to estrogen receptor status. J Nutr 133: 2342–2347, 2003

168.   Loft S, , Møller P Vogel U, Risom L, Riis B, Poulsen HE, Dybdal M, Dragsted LO, Knudsen LE, Wallin H. Oxidative stress by environmental agents. J Univ Occup Environ Health 25 suppl. 1: 47-59, 2003

169.   Risom L, Møller P, HansenM, Autrup H, Bornholt J, Vogel U, Wallin H, Poulsen HE, Dragsted LO, Loft S. Dietary low-dose sucrose modulation of diesel-induced genotoxicity in the colon and liver of Big Blue^Ò rats. Arch Toxicol 77: 651-656, 2003

170.   Vogel U, Danesvar B, Autrup H, Risom L, Weimann A, Poulsen HE, Møller P, Loft S, Wallin H,  Dragsted L. Lard-increased mRNA levels of the DNA repair gene ERCC1 and decreased bulky DNA adducts in rat liver. Free Radical Res 37: 947-956, 2003

171.   Risom L, Møller P, Vogel U, Kristjansen PEG, Loft S. X-ray-induced oxidative stress: DNA damage and gene expression of HO-1, ERCC1 and OGG1 in mouse lung. Free Radical Res 37: 957-966, 2003

172.   Lundby C, Pilegaard H, van Hall G, Sander M, Calbet J, Loft S, Møller P. Oxidative DNA damage and repair in skeletal muscle of humans exposed to high altitude hypoxia. Toxicology 192: 229-36, 2003

173.   Risom L, Dybdahl M, Bornholdt J, Vogel U, Wallin H, Møller P, Loft S. Oxidative DNA damage and defence gene expression in the mouse lung after short-term exposure to diesel exhaust particles by inhalation. Carcinogenesis 24: 1847-52, 2003

174.   Dybdahl, M Risom L, Møller P, Autrup H, Wallin H,Vogel U, Bornholdt J, Daneshvar B, Dragsted, L  Weimann A, Poulsen HE, Loft S. DNA adduct formation and oxidative stress in colon and liver of Big Blue® rats after dietary exposure to diesel particles. Carcinogenesis 24:1759-1766, 2003

175.   Møller P, Vogel U, Pedersen A, Dragsted LO, Sandström B, Loft S. No effect of 600 g fruit and vegetables per day on oxidative DNA damage and repair in healthy non-smokers. Cancer Epidemiol Biomarkers Prev 12:1016-22, 2003

176.   Sørensen M, Autrup H,Møller P, Hertel O, Jensen SS, Vinzents P, Knudsen LE, Loft S. Linking exposure to environmental pollutants with biological effects. Mutation Res - Rev Mutation  Res 544: 555-571, 2003

177.   Kramer I, Dalhoff K, Clemmesen JO, Loft S, Poulsen HE.Comparison of chlorzoxazone one-sample methods to estimate CYP2E1 activity in humans. Eur J Clin Pharmacol 59:775-778. 2003

178.   Hansen ÅM, Wallin H, Binderup ML, Dybdahl M, Autrup H, LoftS, Knudsen LE. Urinary 1-hydroxypyrene and mutagenicity in bus drivers and mail carriers exposed to urban air pollution in Denmark. Mutation Res  - Gen Toxicol Environ Mutagenesis. 557; 7-17, 2004

179.   Poulsen HE, Møller P, Lykkesfeldt  J, Weimann A, Loft S. Vitamin C and Oxidative Damage to DNA. In Vitamin C, Functions and Biochemistry in Animals and Plants. Eds.: Asard H, May JM, Smirnoff N. BIOS Scientific Publishers, UK 2004, pp 189-202.

180.   Wellejus A, Bornholdt J, Vogel UB, Risom L, Wiger R, Loft S. Cell-specific oxidative DNA damage induced by estrogen in rat testicular cells in vitro. Toxicol Lett 150: 317-323, 2004

181.   Müller AK, Olatunde Farombi E, Møller P, Autrup H, Vogel U, Wallin H,Dragsted LO, Loft S, Binderup ML. DNA damage in lung after oral exposure to diesel exhaust particles in Big Blue® rats. Mutation Res - Gen Toxicol Environ Mutagenesis 550:123-32, 2004

182.   Møller P, Loft S, Alfthan G, Freese R. Oxidative DNA damage in circulating mononuclear blood cells after ingestion of blackcurrant juice or anthocyanin-rich drink. Mutation Res - Fund Mol Mech 551:119-26, 2004

183.   Møller P, Loft S. Interventions with antioxidants and nutrients in relation to oxidative DNA damage and repair. Mutation Res - Fund Mol Mech 55:79-89, 2004

184.   Dragsted LO, Pedersen A, Hermetter A, Basu S, Hansen M, Ravn-Haren G, Kall M, Breinholt V, Jacobsen J, Castenmiller J, Stagsted J,  Skibsted L, Nielsen SE, Loft S, Sandström B. The 6-a-day study: Effects of fruits and vegetables on markers of oxidative stress and defence in healthy non-smokers. Am J Clin Nutr 79:1060-72, 2004

185.   Vistisen K, Loft S, Olsen JH, Vallentin S, Ottesen S, Hirsch FR, Poulsen HE.Low CYP1A2 activity associated with testicular cancer. Carcinogenesis 25: 923-9, 2004

186.   Møller P, Loft S. Oksidative DNA skader i humane leukocytter i antioksidant interventionsstudier. Ugeskr f Læg. 166:1902-4, 2004

187.   Hansen M, Hald MT, Autrup H, Vogel U, Bornholdt J, Møller P, Mølck A-M, Lindecrona R, Poulsen HE, Wallin H, Loft S, Dragsted LO. Sucrose and IQ induced mutations in rat colon: no effect of sucrose on the mutation spectrum. Mutation Res - Fund Mol Mech 554: 279-286, 2004

188.   Dybdahl M, Risom L, Bornholdt J, AutrupH, LoftS, Wallin H. Inflammatory and genotoxic effects of diesel  particles in vitro and in vivo. Mutation Res - Gen Toxicol Environ Mutagenesis 562: 119-131, 2004

189.   Sørensen M,  Poole J, Autrup H, Muzyka V, Jensen A, Loft S, Knudsen LE. Benzene exposure assessed by metabolite excretion in Estonian oil shale mine workers: influence of GST polymorphisms. Cancer Epidemiol Biomarker Prev 13: 1729-1735, 2004

190.   Møller P, Viscovich M, Lykkesfeldt J, Loft S, Jensen A, Poulsen HE. Vitamin C supplementation decreases oxidative DNA damage in mononuclear blood cells of smokers. Eur J Nutr 43: 267-274, 2004

191.   Olsen A, Knudsen KEB, Thomsen BL, Loft S,  Stripp C, Overvad K, Møller S, Tjønneland A.Plasma enterolactone and breast cancer incidence rate according to estrogen receptor status. Cancer Epidemiol Biomarker Prev13: 2084-2089, 2004

192.   Møller P, Friis G, Christensen PH, Risom L, Plesner G, Kjærsgaard J, Vinzents P, Loft S, Jensen A, Tved M. Intra-laboratory comet assay sample scoring exercise for determination of formamidopyrimidine DNA glycosylase sites in human mononuclear blood cell DNA. Free Radical Res 11: 1207–1214, 2004.

193.   Agudo A, Bailey BS, Bradlow HL, Byers T, Chung L, Dragsted LO, Hayes J, Hecht SS, Johnson IT, Kassie F, Loft, S, Manson MM, Miller AB, Mithen R, Nishikawa A, Schut HAJ, Seow A, Stoner G, Taioli E, Thornalley JP, Vang O, Zhang Y, IARC Working Group on the Evaluation of Cancer-Preventive Agents. Cruciferous vegetables, isothiocyanates and indoles. IARC Handbooks of Cancer Prevention Vol. 9, Lyon, IARC, pp. 1-262, 2004

194.   Saber AT, Bornholdt J, Dybdahl M, Sharma AK, Loft S, Vogel U, Wallin H. Tumor necrosis factor is not required for particle-induced genotoxicity and pulmonary inflammation. Arch Toxicol 79:177-82, 2005

195.   Avobge PH, Ayi-Fanou L, Autrup H, Loft S, Fayomi B, Sanni A, Vinzents P, Peter Møller. Ultrafine particulate matter and high-level benzene urban air pollution in relation to oxidative DNA damage. Carcinogenesis 26: 613-20, 2005

196.   Bak H, Christensen J, Thomsen BL, Tjønneland A, Overvad K, Loft S, Raaschou-Nielsen O. Physical activity and risk for lung cancer in a Danish cohort. Int J Cancer, 116: 439-44, 2005

197.   LO Dragsted, G Ravn-Haren, M Hansen, M Kall, V Breinholt, J Jakobsen, SE Rasmussen, A Pedersen, B Sandström, A Hermetter, S Basu, J Castenmiller, J Stagsted, LH Skibsted, S Loft. Effect of changes in fruit and vegetable intake on plasma antioxidant defences in humans - reply. Am J Clin Nutr  81: 532-534, 2005

198.   Risom L, Møller P, Loft S. Oxidative stress-induced DNA damage by particulate air pollution. Mutation Res592: 119–137, 2005

199.   Sørensen M, Loft S, Andersen HV, Raaschou-Nielsen O, Skovgaard LT, Knudsen LE, Nielsen IV, Hertel O. Personal exposure to PM2.5, black smoke and NO2 in Copenhagen: relationship to bedroom and outdoor concentrations covering seasonal variation. J Exposure Analysis Environ Epidemiol 15: 413-22, 2005.

200.   Sørensen M, Schins RPF, Hertel O, Loft S. Transition metals in personal samples of PM2.5 particles and oxidative stress in human volunteers. Cancer Epidemiol Biomarker Prevention 14:1340-3, 2005

201.   Laskaa MJ, Nexø BA, Vistisen K, Poulsen HE, Loft S, Vogel U. Polymorphisms in RAI and in Genes of Nucleotide and Base Excision Repair are not associated with Risk of Testicular Cancer. Cancer Lett 225: 245-51, 2005

202.   Wellejus A, Olsen A, Tjonneland A, Thomsen BL, Overvad K, Loft S. Urinary hydroxyestrogens and breast cancer risk among postmenopausal women. Cancer Epidemiol Biomarker Prevention 14: 2137-42, 2005

203.   Vinzents PS, Møller P, Sørensen M, Knudsen LE, Hertel O, Jensen FP, Schibye B, Loft S. Personal Exposure to Ultrafine Particles and Oxidative DNA Damage. Environ Health Perspec 113: 1485-90, 2005

204.   Aarnio P, Mussalo-Rauhamaa H, Makinen-Kiljunen S, Saarela K, Loft S.  Indoor air problems in a healthcare centre - A case report of a follow-up. Indoor Built Environ 14: 433-441, 2005

205.   Dubois J, Duez P, Kouegnigan L, Rees J-F, Loft S, Møller P, Jensen A, Poulsen H, Riis B, Weimann A, Cadet J,  Douki T, Ravanat J-L, Sauvaigo S, Faure H, Morel I, Morin B, Epe B, Eckert I, Hartwig A, Schwerdtle T, Dolara P, Giovannelli L, Lodovici M, Guglielmi F, Olinski R, Bialkowski K, Foksinski M, Gackowski D, Duracková Z,  Muchová J, Korytar P, Sivonová M, Dušinská M, Mislanová C, Petrovská H, Smolková B, Viña J, Lloret A, Möller L, Hofer T, Eriksson H, Gremaud E, Herbert K, Wild C, Kelly F, Dunster C, White A, Wood S, Vaughan N, Gedik CM, Andrew Collins A. Base oxidation in human lymphocyte DNA: results of an inter-laboratory validation study. FASEB J 2005; 18:82-84.

206.   Dragsted LO, Krath B,  Ravn-Haren G, Vogel UB, Vinggaard AM, Jensen PB, Loft S, Rasmussen SE, Sandström B, Pedersen A Hermetter. Biological effects of fruit and vegetables. Proc Nutr Soc 65: 1-8, 2006

207.   Bak H, Autrup H, Thomsen BL, Tjonneland A, Overvad K, Vogel U, Raaschou-Nielsen, Loft S. Bulky DNA adducts as risk indicator of lung cancer in a Danish case-cohort study. Int J Cancer 118:1618-22, 2006

208.   Saber AT,Jacobsen NR, Bornholdt J, Kjær SL, Dybdahl M, Risom L, Loft S. Cytokine expression in mice exposed to diesel exhaust particles by inhalation -  Role of tumor necrosis factor. Particle Fibre Toxicol 3:4     doi:10.1186/1743-8977-3-4, 2006

209.   Loft S, Risom L, Møller P. Chemical composition and surface areas in relation to health effects of ultrafine particles. Mutation Res 594: 199-200, 2006  

210.   Ayi-Fanou L, Mobio TA,  Creppy EE, Fayomi B, Fustoni S, Møller P, Kyrtopoulos S, Georgiades P, Loft S, Sanni A, Skov H, Øvrebø S, Autrup H. Markers of air pollution in Cotonou, Benin - personal monitoring and biomarkers. Sci Total Environ, 358:85-96, 2006

211.   Loft S, Møller P. Oxidative DNA damage and human cancer: need for cohort studies. Antioxidants Redox Signalling 8: 1021-1031, 2006

212.   Loft S, Svoboda P, Kasai H, Tjønneland A, Vogel U, Møller P, Overvad K, Raaschou-Nielsen O. Prospective study of 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion and the risk of lung cancer. Carcinogenesis 27: 1245-1250, 2006

213.   Møller P, Loft S. Dietary antioxidants and beneficial effect on oxidatively damaged DNA. Free Radical Biol Med, 41: 388-415, 2006

214.   Johnsen NF, Christensen J, Thomsen BL, Olsen A, Loft S, Overvad K, Tjønneland A. Physical activity and risk of colon cancer in a cohort of Danish middle-aged men and women. Eur J Epidemiol 21:877–884, 2006

215.   Raaschou-Nielsen O, Thomsen BL, Overvad K, Tjonneland A, Vogel U, Bak H, Autrup H, Loft S. Bulky DNA adducts as risk indicators of lung cancer in a Danish case-cohort study. Int J Cancer 120: 212–213, 2007

216.   Löndahl J, Massling A, Pagels J, Swietlicki E, Vaclavik E, Loft S. Size-Resolved Respiratory Tract Deposition of Fine and Ultrafine Hydrophobic and Hygroscopic Aerosol Particles during Rest and Exercise. Inhalation Toxicology 19:109-16, 2007

217.   Sørensen M, Bisgaard H, Stage M, Loft S. Biomarkers of exposure to environmental tobacco smoke in infants. Biomarkers 12: 38-46, 2007

218.   Risom L, Dybdahl M, Møller P, Wallin H, Haug T, Vogel U, Klungland A, Loft S. Repeated inhalations of diesel exhaust particles and oxidatively damaged DNA in young oxoguanine DNA glycosylase (OGG1) deficient mice, Free Radical Res 41: 172-181, 2007

219.   Hansen CS, Sheykhzade M, Møller P, Folkmann JK, Amtorp O, Jonassen T, Loft S. Diesel exhaust particles induce endothelial dysfunction in apoE^-/- mice. Toxicol Appl Pharmacol219: 24–32, 2007

220.   Folkmann JK, Loft S, Møller P.  Oxidatively damaged DNA in aging dyslipidemic ApoE^-/- and wild type mice. Mutagenesis 22: 105-110, 2007

221.   Tuomainen T-P, Loft S, Nyyssönen K. Punnonen K, Salonen JT, Poulsen HE. Body iron is a contributor to oxidative damage of DNA. Free Radical Res 41: 324-328, 2007

222.   Folkmann JK, Risom L, Hansen CS, Loft S, Møller P. Oxidatively damaged DNA and inflammation in dyslipidemic ApoE-/- mice exposed to diesel exhaust particles. Toxicology 237: 134-144, 2007

223.   Bräuner EV, Forchhammer L, Møller P, Simonsen J, Glasius M, Wåhlin M, Raaschou-Nielsen O, Loft S. Exposure to ultrafine particles from ambient air and oxidative stress-induced DNA damage. Environ Health Perspect 115: 1177-1182, 2007

224.   Loft S, Svoboda P, Kasai H, Tjønneland A, Møller P, Sørensen M. Overvad K, Autrup H, Raaschou-Nielsen O. Prospective study of urinary excretion of 7-methylguanine and the risk of lung cancer: effect modification by mu class glutathione-S-transferases. Int J Cancer121: 1579-84, 2007

225.   Jacobsen NR, Saber AT, Møller P, Pojana G, Vogel U, Loft S, Gingerich J, Soper L, Douglas GR, White P,  Wallin H. Increased mutant frequency by carbon black, but not quartz, in the lacZ and cII transgenes of Muta™Mouse lung epithelial cells. Environ Mol Mutagenesis 48: 451-461, 2007

226.   Møller P, Loft S. The role of antioxidants in the prevention of oxidative damage to nucleic acids. In Oxidative Damage to Nucleic Acids, Eds. Evans MD, Cooke MS. Springer New York, USA 2007, pp. 207-223

227.   Risom L, Lundby C, Thomsen JJ, Mikkelsen L, Loft S, Friis G, Møller P. Acute hypoxia and reoxygenation-induced DNA oxidation in human mononuclear blood cells. Mutation Res 625: 125–133, 2007

228.   Risom L, Møller P, Dybdahl M, Vogel U, Wallin H, Loft S,. Dietary exposure to diesel exhaust particles and oxidatively damaged DNA in young oxoguanine DNA glycosylase 1 deficient mice. Toxicol Lett175: 16-23, 2007

229.   Andersen ZJ, Wåhlin P, Raaschou-Nielsen, Scheike T, Loft S. Ambient Particle Source Apportionment and Daily Hospital Admissions among Children and Elderly in Copenhagen. J Exposure Sci Environ Epidemiol 17: 625-36, 2007

230.   Danielsen PH, Risom L. Wallin H, Autrup H, Vogel U, Loft S, Møller P.  DNA damage in rats after a single oral exposure to diesel exhaust particles. Mutation Res 637: 49-55, 2008

231.   Hansen M, Baunsgaard D, Autrup H, Vogel U, Møller P, Lindecrona R, Wallin H, Poulsen HE, Loft S, Dragsted LO. Sucrose, glucose and fructose have similar genotoxicity in the rat colon and affect the metabolome. Food Chem Toxicol 46: 752-760, 2008

232.   Hertel O, Solvang Jensen S, Hvidberg M, Ketzel M, Berkowicz R, Palmgren F, Wåhlin P, Glasius M, Loft S,  Vinzents P, Raaschou-Nielsen O, Sørensen M, Bak H. Assessing the Impacts of Traffic Air Pollution on Human Exposure and Health. in Road Pricing, the Economy, and the Environment. Eds. Jensen-Butler C, Sloth B, Larsen MM, Madsen B, Nielsen O. pp. 277-300. Springer 2008.

233.   Cooke MS, Olinski R, Loft S, Evans MD, Singh R, Mistry V, Farmer PB, Rozalski R, Gackowski D, Foksinski M, Siomek A, Moller P, Danielsen P, Vaclavik E, Forchhammer L, Cadet J, Ravanat J-L, Nair J, Nair U, Poulsen HE,  Weimann A, Hillestrom P. Measurement and meaning of oxidatively-modified DNA lesions in urine. Cancer Epidemiol Biomarkers Prev 17: 3-14, 2008

234.   Bräuner EV, Møller P. Forchhammer L. Barregard L. Gunnarsen L, Afshari A, Wåhlin P, Glasius M, Dragsted LO, Basu S, Raaschou-Nielsen O, Loft S. Indoor Particles Affect Vascular Function in the Aged: An Air Filtration-based Intervention Study. Am J Resp Critical Care Med 177: 419-25, 2008

235.   Hatt L, Loft S, Risom L, Møller P, Sørensen M, Raaschou-Nielsen O, Overvad K, Tjønneland A, Vogel U. OGG1 expression and OGG1 Ser326Cys polymorphism and risk of lung cancer in a prospective study. Mutation Res 639: 45-54, 2008

236.   Guarnieri S, Loft S, Riso P, Porrini M, Risom L, Poulsen HE, Dragsted LO, Møller P. DNA repair phenotype and dietary antioxidant supplementation. Br J Nutr 99: 1018-1024, 2008

237.   Loft S, Bräuner EV, Forchhammer L, Pedersen M, Knudsen LE, Møller P. Complex exposures – air pollution. In Molecular Epidemiology of Chronic Disease. Eds. Wild C, Vineis P, Garte S. Wiley Press, NJ 2008, pp 343-368.

238.   Wellejus A, Jensen H, Loft S, Jonassen T. Expression of Aquaporin 9 in Rat Liver and Efferent Ducts of the Male Reproductive System after Neonatal Dethylstilbestrol Exposure. J Histochem Cytochem 56: 425-32, 2008

239.   Jacobsen NR, Møller P, Cohn CA, Loft S, Vogel U, Wallin H. Diesel exhaust particles are mutagenic in FE1-Muta™Mouse lung epithelial cells. Mutation Res 641: 54–57, 2008

240.   Danielsen PH, Loft S, Møller P. DNA damage and cytotoxicity in type II lung epithelial (A549) cell cultures after exposure to diesel exhaust and urban street particles. Particle Fibre Toxicol 5:6, doi:10.1186/1743-8977-5-6, 2008.

241.   Forchhammer L, Bräuner EV, Folkmann JK, Danielsen PH, Nielsen C, Jensen A, Loft S, Friis G, Møller P. Variation in assessment of oxidatively damaged DNA in mononuclear blood cells by the comet assay with visual scoring. Mutagenesis 23: 223-231, 2008

242.   Loft S, Møller P, Cooke MS, Rozalski R, Olinski R: Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker ? Eur J Nutr 47 (Suppl. 2): 19–28, 2008

243.   Møller P, Folkmann JK, Forchhammer L, Bräuner EV, Danielsen PH, Risom L, Loft S. Air pollution, oxidative damage to DNA and carcinogenesis. Cancer Lett 266: 84-97, 2008

244.   Danielsen PH, Bräuner EV, Barregard L, Sällsten G, Wallin M, Olinski R, Rozalski R, Møller P, Loft S. Oxidatively damaged DNA and its repair after experimental exposure to wood smoke in healthy humans. Mutation Res642: 37-42, 2008

245.   Andersen ZJ, Wåhlin P,  Raaschou-Nielsen, Ketzel M, Scheike T, Loft S. Size Distribution and Total Number Concentration of Ultrafine and Accumulation Mode Particles and Hospital Admissions in Children and the Elderly in Copenhagen, Denmark. Occup Environ Med 65: 458-66, 2008

246.   Jacobsen NR, Pojana G, White P, Møller P, Cohn CA, Korsholm KS, Vogel U, Marcomini U, Loft S, Wallin H. Genotoxicity, cytotoxicity and reactive oxygen species by single-walled carbon nanotubes and C60 fullerenes in the FE1-Muta™Mouse lung epithelial cells. Environ Mol Mutagenesis 49: 476-487, 2008

247.   Veglia F, Loft S, Matullo G, Peluso M, Munnia M, Perera F,  Phillips DH, Tang D, Autrup H, Raaschou-Nielsen O, Tjønneland A, Vineis Pfor the Genair-EPIC investigators. DNA adducts and cancer risk in prospective studies: a pooled analysis and a meta-analysis. Carcinogenesis 29: 932-936, 2008

248.   Gallo V,  Khan A, Gonzales C, Phillips DH, Schoket B, Gyorffy E, Anna L, Kovács K, Møller P, Loft S, Kyrtopoulos S, Matullo G, Vineis P. Validation of biomarkers for the study of environmental carcinogens: a review. Biomarkers 13: 505-534, 2008

249.   Andersen ZJ, Loft S, Ketzel M, Stage M, Scheike T, Hermansen MN, Bisgaard H. Ambient Air Pollution Triggers Wheezing Symptoms in Infants. Thorax 63: 710-716, 2008

250.   Freeese R, Dragsted LO, Loft S, Mutanen M. No effect on oxidative stress biomarkers by modified intakes of polyunsaturated  fatty acids or vegetables and fruit. Eur J Clin Nutr 62:1151-1153, 2008.

251.   Loft S, Danielsen PH, Mikkelsen L, Risom L, Møller P. Biomarkers of oxidative damage to DNA and repair. Biochem Soc Trans 36:1071-1076, 2008

252.   Møller P, Risom L, Lundby C, Mikkelsen L, Loft S. Hypoxia and oxidation levels of DNA and lipids in humans and animal experimental models. IUBMB Life 60: 707-723, 2008

253.   Bräuner EV, Møller P, Barregard L, Glasius M, Wåhlin P, Vinzents P, Raaschou-Nielsen O, Loft S. Exposure to ambient concentrations of particulate air pollution does not influence vascular function or inflammatory pathways in young healthy individuals. Particle Fibre Toxicol 5: 13, doi:10.1186/1743-8977-5-13, 2008

254.   Egeberg R, Olsen A, Loft S, Christensen J, Johnsen NF, Overvad K, Tjønneland A. Intake of whole grain products and risk of breast cancer by hormone receptor status and histology among postmenopausal women. Int J Cancer 124: 745-750, 2009

255.   Brauner EV. Mortensen J, Møller P, Bernard A, Vinzents P, Wåhlin P, Glasius M, Loft S. Effects of Ambient Air Particulate Exposure on Blood-gas Barrier Permeability and Lung-function. Inhalation Toxicol21: 38-47, 2009

256.   Saber AT, Vogel U, Loft S, Wallin H. Particle-induced Cancer. in Encyclopedia of Cancer 2^nd edition. Ed Schwab M. Springer Berlin, 2009, pp 2265-2267.

257.   Nørskov MS, Frikke-Schmidt R, Loft S, Tybjærg-Hansen A.. High-Throughput Genotyping of Copy Number Variation in Glutathione S-Transferases M1 and T1 using Real-Time PCR. Clinical Biochemistry 42: 201-209, 2009

258.   Jacobsen NR, Møller P,  Jensen KA, Vogel U, Ladefoged O, Loft S, Wallin H. Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE-/- mice. Particle Fibre Toxicol 6: 2, 2009

259.   Danielsen PH, Loft S, Kocbach A, Schwarze PE, Møller P. Oxidative damage to DNA and repair induced by Norwegian wood smoke particles in human A549 and THP-1 cell lines. Mutation Res 674:  116-122, 2009

260.   Sørensen LT, Jørgensen S, Petersen LJ, Hemmingsen U, Bülow J, Loft S, Gottrup F. Acute effects of nicotine and smoking on blood flow, tissue oxygen and aerobe metabolism of the skin and subcutis. J Surg Res152: 224-30, 2009

261.   Vesterdal LK, Folkmann JF, Jacobsen NR, Sheykhzade M, Wallin H, Loft S, Møller P. Modest vasomotor dysfunction induced by C60 fullerenes in apolipoprotein E knockout mice with different degree of atherosclerosis. Particle Fibre Toxicol 6:5, 2009 doi:10.1186/1743-8977-6-5

262.   Folkmann JK, Risom L, Jacobsen NR, Wallin H, Loft S, Møller P. Oxidatively Damaged DNA in Rats Exposed by Oral Gavage to C₆₀ Fullerenes and Single-walled Carbon Nanotubes. Environ Health Perspect 117:703–708,  2009

263.   Hansen RD, Krath BN, Frederiksen K, Tjønneland A, Overvad K, Roswall N, Loft S, Dragsted LO, Vogel U, Raaschou-Nielsen O.GPX1 Pro198Leu polymorphism, erythrocyte GPX activity, interaction with alcohol consumption and smoking, and risk of colorectal cancer. Mutation Res664: 13–19, 2009

264.   Saber AT, Halappanavar S, Folkmann JF, Bornholdt J, Boisen AM, Møller P, Williams A, Yauk C, Vogel U,  Loft S, Wallin H. Lack of acute phase response in the liver of mice exposed to diesel exhaust particles and carbon black by inhalation. Particle Fibre Toxicol 6: 12, 2009

265.   Johnsen NF, Tjønneland A, Thomsen BL, Christensen J, Loft S, Friedenreich C, Key TJ, Allen NE, Lahmann PH, Mejlvig L, Overvad K, Kaaks R, Rohrmann S, Boing H, Misirli G, Trichopoulou A, Zylis D, Tumino R, Pala V,  Bueno-de-Mesquita HB, Kiemeney LA, Suárez LR, Gonzalez CA, Sánchez M-J, Huerta JM, Gurrea AB,  Manjer J, Wirfält E, Khaw K-T, Wareham N, Boffetta P, Egevad L, Rinaldi S, Riboli E. Physical activity and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Int J Cancer 125: 902-8, 2009

266.   Löndahl J, Massling A, Bräuner, EV, Swietlicki E, Ketzel M, Pagels J, Loft S. Experimentally Determined Human Respiratory Tract Deposition of Airborne Particles at a Busy Street. Environ Sci Tech 43: 4659–64, 2009

267.   Mikkelsen L, Bialkowski K, Risom R, Loft S, Moller P. Aging and defence against generation of 8-oxo-7,8-dihydro-2'-deoxyguanosine in DNA. Free Radical Biol Med 47: 608-15, 2009

268.   Sørensen M, Allermann L, Vogel U, Andersen PS, Jespersgaard C, Loft S,  Raaschou-Nielsen O. Polymorphisms in inflammation genes, tobacco smoke and furred pets and wheeze in children. Pediatric Allergy Immunol 20: 614-23, 2009

269.   Egeberg R, Frederiksen K, Olsen A, Johnsen NF, Loft S, Overvad K, Tjønneland A. Intake of whole grain products is associated with dietary, lifestyle, anthropometric and socioeconomic factors in Denmark. Public Health Nutr12:1519-30, 2009

270.   Hemmingsen JG, Hougaard KS, Talsness C, Wellejus A, Loft S, Wallin H, Møller P. Prenatal exposure to diesel exhaust particles and effect on the male reproductive system in mice. Toxicology264: 61-68, 2009

271.   Loft S. Luftkvalitet og klimaforandringer. Ugeskr f Læger171: 3168-71, 2009

272.   Pedersen M, Wichmann J, Autrup H, Dang DA, Hvidberg M, Bossi R, Jakobsen J, Loft S, Knudsen LE. Increased micronuclei and bulky DNA adducts in cord blood after maternal exposures to traffic-related air pollution. Environ Res109: 1012-20, 2009

273.   Aitken R, Borm P, Donaldson K, Ichihara G, Loft S, Marano F, Maynard A, Oberdörster G, Stamm H, Stone V, Tran L, Wallin H. Nanoparticles:- one word: a multiplicity of different hazards. Nanotoxicology 3: 263-4, 2009.

274.   Møller P, Jacobsen NR, Folkmann J, Danielsen P, Mikkelsen L, Hemmingsen J, Vesterdal L, Forchhammer L, Wallin H, Loft S. Role of oxidative damage in toxicity of particulates. Free Radical Res 44: 1-46, 2010

275.   Johnsen NF, Olsen A, Thomsen BLR, Christensen J, Egeberg R, Knudsen KEB, Loft S, Overvad K, Tjønneland A. Plasma enterolactone and risk of colon and rectal cancer in a case-cohort study of Danish men and women. Cancer Causes Control 21:153-162, 2010

276.   Raaschou-Nielsen O, Hermansen MN, Loland L. Buchwald F, Pipper CB, Sørensen M, Loft S, Bisgaard H. Long-term exposure to indoor air pollution and wheezing symptoms in infants. Indoor Air 20: 159-167, 2010

277.   Forchhammer L, Johansson C, Loft S, Möller L, Godschalk R, Langie S, Jones G, Kwok R, Oscoz A, Collins A, Phillips D, Brookes L, Sozeri O, Stepnik M, Palus J, Vogel U, Wallin H, Routledge M, Handforth C, Allione A, Møller P. Variation in the measurement of DNA damage by comet assay measured by the ECVAG inter-laboratory validation trial. Mutagenesis 25: 113-23, 2010

278.   Johansson C, Møller P, Forchhammer L, Loft S, Godschalk RW, Langie S, Lumeij S, Jones GD, Kwok RW, Oscoz AA, Phillips DH, Sozeri O, Routledge MN, Handforth C, Riso P, Porrini M, Allione A, Matullo G, Palus J, Stepnik M, Collins AR, Möller L. An ECVAG trial on assessment of oxidative damage to DNA measured by the comet assay. Mutagenesis 25:125-32, 2010

279.   Eriksen KT. Sørensen M, Autrup H, Vogel U, Overvad K, Tjønneland A, Loft S, Raaschou-Nielsen O, Life-style, environmental, and genetic predictors of bulky DNA adducts in a study population nested within a prospective Danish cohort. J Toxicol Environ Health 73: 583-595, 2010

280.   ESCULA [European Standards Committee on Urinary (DNA) Lesion Analysis], Evans MD, Olinski R, Loft S,  Cooke MS. Towards consensus in the analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a non-invasive biomarker of oxidative stress. FASEB J 24:1249-60, 2010

281.   Pedersen M, Halldorsson TI, Mathiesen L, Mose T, Brouwer A, Hedegaard M, Loft S, Kleinjans JSC, Besselink H, Knudsen LE. Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother-newborn pairs.. Environment Int 36: 344-51, 2010

282.   Møller P, Lohr M, Folkmann JK, Mikkelsen L, Loft S. Aging and oxidatively damaged nuclear DNA in animal organs. Free Radicals Biol Med 48: 1275-85, 2010

283.   Cooke M,  Loft S, Olinski R, Evans M, Bialkowski K, Wagner J, Dedon P, Møller P, Greenberg M, Cadet J. Recommendations for standardised description of, and nomenclature concerning, oxidatively damaged nucleobases in DNA. Chem Res Toxicol 23: 705-707, 2010

284.   Raaschou-Nielsen O, Bak H, Sørensen M, Jensen SS, Ketzel M, Hvidberg M, Schnohr P, Tjønneland A, Overvad K, Loft S. Air pollution from traffic and risk for lung cancer in three Danish cohorts. Cancer Epidemiol Biomarker Prev  19:1284-91, 2010

285.   Eriksen KT, Raaschou-Nielsen O, Sørensen M, Roursgaard M, Loft S, Møller P. Genotoxic potential of the perfluorinated chemicals PFOA, PFOS, PFBS, PFNA and PFHxA in human HepG2 cells. Mutation Res 700: 39-43, 2010

286.   Andersen Z, Olsen TS, Andersen KK, Loft S, Ketzel M, Raaschou-Nielsen O. Association between short-term exposure to ultrafine particles and hospital admissions for stroke in Copenhagen, Denmark. Eur Heart J 31: 2034-40, 2010

287.   Møller P, Loft S. Oxidative damage to DNA and lipids as biomarkers of exposure to air pollution. Environ Health Perspec 118: 1126-36, 2010

288.   Egebjerg R, Olsen A, Loft S, Christensen J, Johnsen NF, Overvad K, Tjønneland A. Intake of wholegrain products and risk of colon and rectal cancer – results from the Diet, Cancer and Health cohort study. Br J Cancer 103: 730-4, 2010

289.   Löndahl J, Swietlicki E, Lindgren E, Loft S. Aerosol exposure versus aerosol cooling of climate: What is the optimal emission reduction strategy for human health. Atmospheric Chem Phys 10, 9441–9449, 2010

290.   Riso P, Martini D, Møller P, Loft S, Bonacina G, Moro M, Porrini M.DNA damage and repair activity after broccoli intake in young healthy smokers. Mutagenesis 25: 595-602, 2010

291.   Danielsen PH, Loft S, Jacobsen NR, Jensen KA, Autrup H, Ravanat JL, Wallin H, Møller P. Oxidative stress, inflammation and DNA damage in rats after intratracheal instillation or oral exposure to ambient air and wood smoke particulate matter. Toxicol Sci  118: 574-585, 2010

292.   Vesterdal LK, Folkmann JK, Jacobsen NR, Sheykhzade M, Wallin H, Loft S, Møller P. Pulmonary exposure to carbon black nanoparticles and vascular effects. Particle Fibre Toxicol 7: 33, 2010

293.   Ricceri F, Godschalk R, Peluso M, Phillips D, Agudo A, Georgiadis P, Loft S, Tjønneland A, Raaschou-Nielsen O, Palli D, Perera F, Vermeulen R, Taioli E, Sram RJ, Rosa F, Allione A, Matullo G, Vineis P. Bulky DNA adducts in white-blood cells: a pooled analysis of 3600 subjects. Cancer Epidemiol Biomarkers Prev 19: 3174-81, 2010

294.   Andersen ZJ, Hvidberg M, Jensen SS, Ketzel M, Loft S, Sørensen M, Tjønneland A, Overvad K, Raaschou-Nielsen O. Chronic obstructive pulmonary disease and long-term exposure to traffic-related air pollution: a cohort study. Am J Resp Crit Care Med 183: 455-61, 2011

295.   Danielsen PH, Møller P, Jensen KA, Sharma AK, Wallin H, Bossi R, Autrup H, Mølhave L, Ravanat JL, Briedé J, de Kok T, Loft S. Oxidative stress, DNA damage and inflammation induced by ambient air and wood smoke particulate matter in human A549 and THP-1 cell lines. Chem Res Toxicol 24:168-184, 2011

296.   Loft S, Schins RPF, Møller P. Particulates and oxidative stress. In Cardiovascular Effects of Inhaled Fine and Nano-sized Particles. Eds. Cassee FR, Mills NL, Newby DE. Pp. 251-271. John Wiley & Sons, Inc, NJ, US. 2011.

297.   Paulsen M, Frikke-Scmidt R, Nordestgaard BG, Loft S, Tybjaerg-Hansen A. Copy number variation in glutathione S-transferase T1 and risk of prostate and corpus uteri cancer in the general population. Pharmacogenomics J 11: 292-299, 2011

298.   Møller P, Mikkelsen L, Vesterdal L, Folkmann JK, Forchhammer L, Roursgaard M, Danielsen PH, Loft S. Hazard identification of particulate matter on vasomotor dysfunction and progression of atherosclerosis. Crit Rev Toxicol  41: 339-68, 2011

299.   Raaschou-Nielsen O, Andersen Z, Hvidberg M, Jensen SS, Ketzel M, Sørensen M, Loft S, Overvad K, Tjønneland A. Lung Cancer Incidence and Long-Term Exposure to Air Pollution from Traffic. Environ Health Perspect 119: 860-865, 2011

300.   Frikke-Schmidt H, Roursgaard M, Lykkesfeldt J, Loft S, Nøjgaard JK, Møller P. Effect of vitamin C and iron chelation on diesel exhaust particle and carbon black induced oxidative damage and cell adhesion molecule expression in human endothelial cells. Tox Lett 203:181-189, 2011

301.   Egeberg R, Olsen A, Christensen J, Johnsen NF, Loft S, Overvad K, Tjønneland A. Intake of whole grain products and risk of prostate cancer among men in the Danish Diet, Cancer and Health cohort study. Cancer Cause Control 22:1133-9, 2011

302.   Wichmann J, Andersen Z, Ketzel M, Ellermann T, Loft S. Apparent temperature and cause-specific emergency hospital admissions in Greater Copenhagen, Denmark. PLoS ONE 6: e22904, 2011

303.   Nørskov MS, Frikke-Schmidt R, Loft S, Sillesen H, Grande P, Nordestgaard BG, Tybjærg-Hansen A. Copy Number Variation in Glutathione S-transferases M1 and T1 and Ischemic Vascular Disease: Four Studies and Meta-analyses. Circ Cardiovasc Genet 4: 418-28, 2011

304.   Raaschou-Nielsen O, Andersen JZ,  Hvidberg M, Jensen SS, Ketzel M, Sørensen M, Hansen J, Loft S, Overvad K, Tjønneland A. Air pollution from traffic and cancer incidence in a Danish cohort. Environmental Health 10:67, 2011

305.   Wichmann J, Andersen Z, Ketzel M, Ellermann T, Loft S. Apparent temperature and cause-specific mortality in Copenhagen, Denmark: a case-crossover analysis. Int J Environ Res Public Health 8: 3712-3727, 2011

306.   Hemmingsen JG, Møller P, Nøjgaard JK, Roursgård M, Loft S. Oxidative stress, genotoxicity, and vascular cell adhesion molecule expression in cells exposed to particulate matter from combustion of conventional diesel and methyl ester biodiesel blends. Environ Sci Tech 45: 8545-51, 2011

307.   Mikkelsen L, Sheykhzade M, Jensen KA, Saber AT, Jacobsen NR, Vogel U, Wallin H, Loft S, Møller P. Modest effect on plaque progression and vasodilatory function in atherosclerosis-prone mice exposed to nanosized TiO2. Particle Fibre Toxicol 8: 32-, 2011

308.   Loft S, Møller P. Oxidative Stress to DNA and Lipids – Relation to Air Pollution. In Biomarkers and Human Biomonitoring 2: Selected Biomarkers of Current Interest, eds. Knudsen LE, Merlo DF. Royal Society of Chemistry,  pp. 160-173, 2012.

309.   Petersen RK, Larsen SB, Jensen DM, Christensen J, Olsen A, Loft S, Nellemann C, Overvad K, Kristiansen K, Tjønneland A, Vogel U. PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer. Cancer Lett 315: 59-68, 2012

310.   Andersen ZJ, Bønnelykke K, Hvidberg M, Jensen SS, Ketzel M, Loft S, Sørensen M, Tjønneland A, Overvad K,  Raaschou-Nielsen O. Long-term exposure to air pollution and asthma hospitalizations in elderly adults: a cohort study. Thorax 67: 6-11, 2012

311.   Andersen ZJ, Raaschou-Nielsen O, Carstensen B, Hvidberg M, Jensen SS, Ketzel M, Loft S, Tjønneland A, Overvad K, Sørensen M. Diabetes incidence and long-term exposure to air pollution: a cohort study. Diabetes Care 35: 92-98, 2012

312.   Jensen A, Løhr M, Eriksen L, Grønbæk M, Dorry E,  Loft S, Møller P. Influence of the OGG1 Ser326Cys polymorphism on oxidatively damaged DNA and repair activity. Free Radical Biol Med 52: 118-125, 2012

313.   Loft S, Svoboda P, Kawai K,  Kasai K,  Sørensen M, Tjønneland A, Vogel U, Møller P, Overvad K, Raaschou-Nielsen O. Association between 8-oxo-7,8-dihydro-guanine excretion and risk of lung cancer in a prospective study. Free Radical Biol Med 52: 167-72, 2012

314.   Bräuner EV, Loft S, Raaschou-Nielsen O, Vogel U,  Skytt Andersen P, Sørensen M. Effects of a 17q21 chromosome gene variant, tobacco smoke and furred pets on infant wheeze. Genes Immunity 13: 94-7, 2012

315.   Forchhammer L, Loft S, Roursgaard M, Cao Y, Riddervold IS, Sigsgaard T, Moller P. Expression of adhesion molecules, monocyte interactions and oxidative stress in human  endothelial cells exposed to wood smoke and diesel exhaust particulate matter. Toxicol Lett 209: 121-8, 2012

316.   Andersen, ZJ, Kristiansen LC, Andersen KK, Olsen TS, Hvidberg M, Jensen SS, Ketzel M, Loft S, Sørensen M, Tjønneland A, Overvad K, Raaschou-Nielsen O. Stroke and long-term exposure to outdoor air pollution from NO2: a cohort study. Stroke 43: 320-5, 2012

317.   Loft S, Danielsen PH, Løhr M, Jantzen K, Hemmingsen JG, Roursgaard M, Karotki DG, Møller P. Urinary excretion of 8-oxo-7,8-dihydroguanine as biomarker of oxidative damage to DNA. Arch Biochem Biophys 518: 142-50, 2012

318.   Cadet J, Loft S, Olinski R, Evans MD, Bialkowski K, Wagner R, Dedon PC, Møller P, Greenberg MM, Cooke MS. Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids. Free Radical Res 46: 367-81. 2012

319.   Møller P, Cooke MS, Collins A, Olinski R, Rozalski R, Loft S. Harmonising measurements of oxidatively damaged DNA. Free Radical Res 46: 541-53, 2012

320.   Bourdon JA, Saber AT, Jacobsen NR, Jensen KA, Madsen AM, Lamson JS, Wallin  H, Møller P, Loft S, Yauk CL, Vogel UB. Carbon Black Nanoparticle Instillation Induces Sustained Inflammation and  Oxidative Stress-Related Genotoxicity in Mouse Lung and Liver. Particle Fibre Toxicol 9: 5, 2012

321.   Leijnse N,  Jeon JH, Loft S, Metzler R, Oddershede LB. Diffusion inside living human cells. Eur Phys J 204: 75-84, 2012

322.   Forchhammer L, Møller P, Riddervold IS, Bønløkke J, Massling A, Sigsgaard T, Loft S. Controlled human wood smoke exposure: oxidative stress, inflammation and microvascular function.  Particle Fibre Toxicol 9: 7, 2012

323.   Wichmann J, Ketzel M, Ellermann T, Loft S. Apparent temperature and acute myocardial infarction hospital admissions in Copenhagen, Denmark: A case-crossover study. Environ Health. 11: 19, 2012

324.   Saber AT, Jensen KA, Jacobsen NR, Birkedal R, Mikkelsen L, Møller P, Loft S, Wallin H, Vogel U. Inflammatory and genotoxic effects of nanoparticles designed for inclusion in paints and lacquers. Nanotoxicology 6: 453-71, 2012

325.   Pedersen M, Halldorsson TI, Autrup H, Brouwer A, Besselink H, Loft S, Knudsen LE. Maternal diet and dioxin-like activity, bulky DNA adducts and micronuclei in mother-newborns. Mutat Res 734: 12-9, 2012

326.   Jackson PJ, Hougaard KS, Boisen AZ, Jacobsen NR, Jensen KA, Peter Møller, Brunborg G, Gutzkow KB, Andersen O, Loft S, Vogel U, Wallin H. Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: Effects on liver DNA strand breaks in dams and offspring. Nanotoxicology 6: 453-71, 2012

327.   Demetriou C, Raaschou-Nielsen O, Loft S, Møller P, Vermeulen R, Palli D, Chadeau-Hyam M, Xun WW,  Vineis P. Biomarkers of ambient air pollution and lung cancer: strength of evidence. Occup Environ Med 69: 619-27, 2012

328.   Folkmann JK, Vesterdal LK, Sheykhzade M, Loft S, Møller P. Endothelial dysfunction in normal and prediabetic rats with metabolic syndrome exposed by oral gavage to carbon black nanoparticles.

329.   Vesterdal LK, Mikkelsen L, Folkmann JF, Sheykhzade M, Cao Y, Roursgaard M, Loft S, Møller P. Carbon black nanoparticles and vascular dysfunction in cultured endothelial cells and aorta segments. Tox Lett 214: 19-26, 2012

330.   Saber AT, Koponen IK, Jensen KA, Jacobsen NR, Mikkelsen L, Møller P, Loft S, Vogel U, Wallin H. Inflammatory and genotoxic effects of sanding dust generated from nanoparticle-containing paints and lacquers. Nanotoxicology 6: 778-88, 2012

331.   Jantzen K, Roursgaard M, Madsen CD, Loft S, Rasmussen LJ, Møller P. Oxidative damage to DNA by diesel exhaust particle exposure in co-cultures of human macrophages and lung epithelial cells. Mutagenesis 27: 693-701, 2012

332.   Forchhammer L, Ersson C, Loft S, Möller L, Godschalk RWL, van Schooten FJ, Jones GDD, Higgins JA, Cooke MS, Mistry V, Karbaschi M, Collins AR, Azqueta A, Phillips DH, Sozeri O, Routledge MN, Nelson-Smith K,  Riso P, Porrini M, Matullo G, Allione A, Stepnik M, Komorowska M, Teixeira JP, Costa S,  Corcuera LA,  López de Cerain A, Laffon B, Valdiglesias V, Møller P. Inter-laboratory variation in DNA damage using a standard comet assay protocol. Mutagenesis 27: 665-72, 2012

333.   Møller P, Folkmann JK, Danielsen P, Jantzen K, Loft S. Oxidative stress generated damage to DNA by gastrointestinal exposure to insoluble particles. Curr Mol Med 12: 732-45, 2012

334.   Raaschou-Nielsen O, Andersen ZJ, Jensen SS, Ketzel M, Sørensen M, Hansen J, Loft S, Tjønneland A, Overvad K. Traffic air pollution and mortality from cardiovascular disease and all causes: a Danish cohort study. Environ Health 11: 60, 2012

335.   Johnston H, Pojana G, Zuin S, Jacobsen NR, Møller P, Loft S, Semmler-Behnke M, McGuiness C, Balharry D, Marcomini A, Wallin H, Kreyling W, Donaldson K, Tran L, Stone V. Engineered nanomaterial risk. Lessons learnt from completed nanotoxicology studies: potential solutions to current and future challenges. Crit Rev Toxicol 43: 1-20, 2013

336.   Jorgensen A, Maigaard K, Wörtwein G, Hageman I, Henriksen T, Weimann A, Møller P, Loft S, Hau J, Poulsen HE, Jorgensen MB. Chronic restraint stress in rats causes sustained increase in urinary corticosterone excretion without cerebral or systemic oxidatively generated DNA/RNA damage. Progr Neuro-Psychopharmacol Biol Psych 40: 30-37, 2013

337.   Raaschou-Nielsen O, Sørensen M, Ketzel M, Hertel O, Loft S, Tjønneland A, Overvad K, Andersen ZJ. Long-term exposure to traffic air pollution and diabetes-related mortality: a cohort study. Diabetologia 56: 36-46, 2013

338.    Møller P, Danielsen PH, Jantzen K, Roursgaard M, Loft S. Oxidatively damaged DNA in animals exposed to particles. Crit Rev Toxicol 43: 96-118, 2013

339.   Wichmann J, Folke F, Torp-Pedersen C, Lippert F, Ketzel M, Ellermannd T, Loft S. Out-of-hospital cardiac arrests and outdoor air pollution exposure in Copenhagen, Denmark. PLoS One 8: e53684, 2013, doi:10.1371/journal.pone.0053684

340.   Mikkelsen L, Jensen KA, Koponen IK, Saber AT, Wallin H, Loft S, Vogel U, Møller P. Oxidative stress and expression of adhesion molecules in human umbilical vein endothelial cells exposed to nanoparticle-containing paint dusts. Nanotoxicology 7: 117-34, 2013

341. DelBo’ C, Riso P, Campolo J,  Møller P,  Loft S, Klimis-Zacas D, Brambilla A, RizzoloA, Porrini M, A single portion of blueberry (Vaccinium corymbosum L.) improvesprotection against DNA damage but not vascular function in healthy malevolunteers. Nutr Res 33: 220-7, 2013

342. KyrøC, Skeie G, Loft S, Overvad K, Christensen J, Tjønneland A, Olsen A. Adherenceto a healthy Nordic food index is associated with a lower risk of colorectalcancer – The Danish Diet, Cancer and Health cohort study. Br J Nutrition 109:920-7, 2013

343. RisoP, Klimis-Zacas D, Del Bo’ C, Martini D, Campolo J, Vendrame S, Møller P, LoftS, De Maria R, Porrini M. Effect of a wild blueberry (Vaccinium angustifolium)drink intervention on markers of oxidative stress, inflamma-tion andendothelial function in humans with cardiovascular risk factors. Eur J Nutr 52:949-61, 2013

344. DallalCM, Stone RA, Cauley JA, Ness RB, Vogel VG, Fentiman IS, Fowke JH, Krogh V,Loft S, Meilahn EN, Muti P, Olsen A, Overvad K, Sieri S, Tjønneland A, Ursin G,Wellejus A, Taioli E. Urinary estrogen metabolites and breast cancer: acombined analysis of individual level data. Int J Biol Markers 28:e3-e16, 2013

345. BarregardL, Møller P, Henriksen T, Mistry V, Koppen G, Rossner P, Sram RJ, Weimann A,Poulsen HE, Nataf R,  Andreoli R, ManiniP, Marczylo TH, Lam P, Evans MD, Kasai H, Kawai K, Li YS, Sakai K,  Singh R, Teichert F, Farmer PB, Rozalski R,Gackowski D, Siomek A, Saez GZ, Cerda C, Broberg K, Lindh K, Hossain MB,Haghdoost S,  Hu CW, Chao MR, Wu KY,Orhan H, Senduran N, Smith RJ, Santella RM, Su Y, Cortez C, Yeh S, Olinski R,Loft S,  Cooke MS. Human andmethodological sources of variability in the measurement of urinary8-oxo-7,8-dihydro-2’-deoxyguanosine. Antioxidants Redox Signal 18:  2377-91, 2013

346. ErssonC, Møller P, Forchhammer L, Loft S, Azqueta A, Godschalk RWL, van Schooten FJ,Jones GDD, Higgins JA, Cooke MS, Mistry V, Karbaschi M, Phillips DH, Sozeri O,Routledge MN, Nelson-Smith K, Riso P, Porrini M, Matullo G, Allione A, StępnikM, Ferlińska M, Teixeira JP, Costa S, Corcuera LA, de Cerain AL, Laffon B,  Val-diglesias V, Collins AR, Möller L. AnECVAG inter-laboratory validation study of the comet assay:inter- andintra-laboratory variation of DNA strand breaks and FPG-sensitive sites inhuman mononuclear cells. Mutagenesis 28: 279-86, 2013

347. KyrøC, Skeie G, Loft S, Landberg R, Christensen J, Lund E, Nilsson LM, Palmqvist R,Tjønneland A, Olsen A. Intake of whole grains from different cereal- and foodsources and incidence of colorectal cancer in the Scandina-vian HELGAcohort.  Cancer Causes Control 24:1363-74, 2013

348. LoftS, Olsen A, Møller P, Poulsen HE, Tjønneland A. Association between8-oxo-7,8-dihydro-2’-deoxyguanosine excretion and risk of postmenopausal breastcancer: nested case-control  study.Cancer Epidemiol Biomarker Prev 22: 1289-96, 2013

349. GodschalkRWL, Ersson C, Riso P, Porrini M, Langie SAS, van Schooten FJ, Azqueta A,Collins AR, Jones GDD, Kwok RWL, Phillips DH, Sozeri O, Allione A, Matullo G,Möller L, Forchhammer L, Loft S, Møller P. DNA repair measurements using themodified comet assay: an inter-laboratory comparison within the European CometAssay Validation Group (ECVAG). Mutation Res 757: 60-7, 2013

350. BräunerEV, Andersen ZJ, Andersen CE, Pedersen C, Gravesen P, Ulbak K, Hertel O, LoftS, Raaschou-Nielsen O. Residential Radon and Brain cancer Incidence in a DanishCohort. PLoS One 8:e744, 2013

351. HertelO, Jensen SS, Ketzel M, Becker T, Peel RG, Ørby PV, Skjøth CA, Ellerman T,Raaschou-Nielsen O, Sørensen M, Brauner EV, Andersen ZJ, Loft S, Bønløkke JH,Sigsgaard T. Utilizing Monitoring Data and Spatial Analysis Tools for ExposureAssessment of Atmospheric Pollutants in Denmark, pp 95-122 in Occurrence, Fateand Impact of Atmospheric Pollutants on Environmental and Human Health. Eds.McConnell LL, Dachs J, Hapeman CJ. American Chemical Society Symposium Series2013. DOI: 10.1021/bk-2013-1149

352. BekoG, Weschler CJ, Wierzbicka A, Karottki DG, Toftum J, Loft S, Clausen GUltrafine particles: Exposure and source apportionment in 56 Danish homes.Environ Sci Technol 47: 10240-8, 2013

353. KarottkiDG, Spilak M, Frederiksen M, Gunnarsen L, Brauner EV, Kolarik B, Andersen ZJ,Sigsgaard T, Barregard L, Strandberg B, Sallsten G, Møller P, Loft S. An indoorair filtration study in homes of elderly: cardiovascular and respiratoryeffects of exposure to particulate matter. Environ Health 12:116, 2013

354. DomijanAM, Miletić-Medved M, Peraica M, Loft S. Malondialdehyde and8-oxo-7.8-dihydro-2'deoxyguanosine in the urine of residents from Balkanendemic nephropathy area in Croatia--a pilot study. Coll Antropol 37:1195-8,2013

355. VesterdalLK, Danielsen PH, Folkmann JK, Jespersen L, Aguilar-Pelaez K, Roursgaard M,Loft S, Møller P. Accumulation of lipids and oxidatively damaged DNA inhepatocytes exposed to particles. Toxicol Appl Pharma-col 274: 350-60, 2014

356. SpilakM, Karottki DG, Frederiksen M, Kolarik B, Loft S Gunnarsen L. Evaluation ofbuilding characteristics in 27 dwellings in Denmark and effect of usingparticle filtration units on PM2.5 concentrations. Building Environ 73: 55-63,2014

357. VesterdalLK, Jantzen K, Sheykhzade M, Roursgaard M, Folkmann JK, Loft S, Møller P.Pulmonary exposure to particles from diesel exhaust, urban dust orsingle-walled carbon nanotubes and oxidatively damaged DNA and vascularfunction in apoE-/-mice. Nanotoxicology 8: 61-71, 2014

358. KyrøC, Olsen A, Landberg R, Skeie G, Loft S, Aman P, Leenders M, Dik VK, SiersemaPD, Pischon T, Christensen J, Overvad K, Boutron-Ruault MC, Fagherazzi G,Cottet V, Kühn T, Chang-Claude J, Boeing H, Trichopoulou A, Bamia C,Trichopoulos D, Palli D, Krogh V, Tumino R, Vineis P, Panico S, Peeters PH,Weiderpass E, Bakken T, Asli LA, Argüelles M, Jakszyn P, Sánchez MJ, Amiano P,Huerta JM, Barricarte A, Ljuslinder I, Palmqvist R, Khaw KT, Wareham N, Key TJ,Travis RC, Ferrari P, Freisling H, Jenab M, Gunter MJ, Murphy N, Riboli E,Tjønneland A, Bueno-de-Mesquita HB. Plasma Alkylresorcinols, Biomarkers ofWhole-Grain Wheat and Rye Intake, and Incidence of Colorectal Cancer. J NatlCancer Inst 106: djt352, 2014

359. CaoY, Jacobsen NR, Danielsen PH, Lenz AG, Stoeger T, Loft S, Wallin H, RoursgaardM, Mikkelsen L,  Møller P. Vasculareffects of multi-walled carbon nanotubes in dyslipidemic ApoE-/- mice and culturedendothelial cells.. Toxicol Sci 138:104-16, 2014

360. MøllerP, Yi C, Vesterdal LK, Danielsen PH, Roursgaard M, Klingberg H, ChristophersenDV, Loft S. Carbon nanotubes and Cardiovascular Disease, pp 331-41. InNanotoxicology: Progress Toward Nanomedicine, 2nd Edi-tion. Eds.Monteriro-Riviere, Tran CL. CRC Press, Taylor and Francis Group, 2014

361. BräunerEV, Loft S, Wellejus A, Autrup H, Tjønneland A, Raaschou-Nielsen O. Adiposetissue PCB levels and CYP1B1 and COMT genotypes in relation to breast cancerrisk in postmenopausal Danish women. Int J Environ Health Res 24: 256-68, 2014

362. KyrøC, Olsen A, Bueno-de-Mesquita HB, Skeie G, Loft S, Aman P, Leenders M, Dik VK,Siersema PD, Pischon T, Christensen J, Overvad K, Boutron-Ruault MC, FagherazziG, Cottet V, Kühn T, Chang-Claude J, Boeing H, Trichopoulou A, Naska A,Oikonomidou D, Masala G, Pala V, Tumino R, Vineis P, Mattiello A, Peeters PH,Bakken T, Weiderpass E, Asli LA, Sánchez S, Jakszyn P, Sánchez MJ, Amiano P,Huerta JM, Barricarte A, Ljuslinder I, Palmqvist R, Khaw KT, Wareham N, Key TJ,Travis RC, Slimani N, Freisling H, Ferrari P, Gunter MJ, Murphy N, Riboli E,Tjønneland A, Landberg R. Plasma alkylresorcinol concentrations, biomarkers ofwhole-grain wheat and rye intake, in the European Prospective Investigationinto Cancer and Nutrition (EPIC) cohort. Br J Nutr 111: 1881-90, 2014

363. JensenA, Karottki DG, Christensen JM, Bønløkke JH, Sigsgaard T, Glasius M, Loft S,Møller P. Biomarkers of oxidative stress and inflammation after wood smokeexposure in a reconstructed Viking Age house. Environ Mol Mutagenesis 55:652-61, 2014

364. RisslerJ, Nordin EZ, Eriksson AC, Nilsson PT, Frosch M, Sporre MK, Wierzbicka A,Svenningsson B, Löndahl J, Messing ME, Sjogren S, Hemmingsen JG, Loft S, PagelsJH, Swietlicki E. Effective density and mixing state of aerosol particles in anear-traffic urban environment. Environ Sci Technol 48: 6300-8, 2014

365. GodschalkRW, Ersson C, Stępnik M, Ferliłska M, Palus J, Teixeira JP, Costa S, Jones GD,Higgins JA, Kain J, Möller L, Forchhammer L, Loft S, Lorenzo Y, Collins AR, vanSchooten FJ, Laffon B, Valdiglesias V, Cooke M, Mistry V, Karbaschi M, PhillipsDH, Sozeri O, Routledge MN, Nelson-Smith K, Riso P, Porrini M, López de CerainA, Azqueta A, Matullo G, Allione A, Møller P. Variation of DNA damage levels inperipheral blood mononuclear cells isolated in different laboratories.Mutagenesis 29: 241-9, 2014

366. Møller P, Loft P, Ersson C, Koppen G, Dusinska M, Collins A. On the search foran intelligible comet assay descriptor. Frontiers Genetics 5: 217, 2014

367. RoursgaardM, Jensen KA, Danielsen PH, Mikkelsen LÆ, Folkmann JK, Forchammer L, Jantzen K,Klingberg H, Cao Y, Loft S, Møller P. User-dependent variability in validation of size determination of nanoparticlesin suspen-sion by means of Nanoparticle Tracking Analysis (NTA) software fromNanoSight. Adv Sci Engineer Med 6, 931-41, 2014

368. BräunerEV, Nordsborg EB, Andersen ZJ, Tjønneland A, Loft S, Raaschou-Nielsen O,Long-Term Exposure to Low-Level Arsenic in Drinking-Water and DiabetesIncidence: A Prospective Study of the Diet, Cancer and Health Cohort. EnvironHealth Perspec 122: 1059-65, 2014

369. KarottkiDG, Bekö G; Clausen G; Madsen AM; Andersen ZJ; Massling A; Ketzel M; EllermannT; Lund R; Sigsgaard T; Møller P; Loft S. Cardiovascular and lung function inrelation to outdoor and indoor exposure to fine and ultrafine particulatematter in middle-aged subjects. Environ Int 73: 372-381, 2014

370. MøllerKL, Thygesen LC, Schipperijn J, Loft S, Bonde JP, Mikkelsen S, Brauer C.Occupational exposure to ultrafine particles among airport employees -Combining personal monitoring and Global Positioning System. PLoS One. 9:e106671, 2014

371. CaoY, Roursgaard M, Danielsen PH, Møller P, Loft S. Carbon black nanoparticlespromote endothelial activation and lipid accumulation in macrophagesindependently of intracellular ROS production. PLoS One 9: e10671, 2014

372. MøllerP, Loft S. Statistical analysis of comet assay results. Frontiers Genetics5:292, 2014

373.MøllerP, Christophersen DV, Jensen DM, Kermanizadeh A, Roursgaard M, Jacobsen NR,Hemmingsen JG, Dan-ielsen PH, Cao Y, Jantzen K, Klingberg H, Hersoug LG, LoftS. Role of oxidative stress in carbon nanotube gener-ated health effects. ArchToxicol 88: 1939-64, 2014

 

374.Kermanizadeh A, Løhr M,  Roursgaard M, Messner S, Gunness P, Kelm JM, Møller P, Stone V,  Loft S. Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue model. Particle Fibre Toxicol 11:56, 2014

375.Olsen Y, Karottki DG, Jensen DM, Bekö G, Kjeldsen BU, Clausen G, Hersoug LG, Holst GJ, Wierzbicka A,  Sigsgaard T, Linneberg A, Møller P, Loft S. Vascular and lung function related to ultrafine and fine particles exposure assessed by personal and indoor monitoring: a cross-sectional study. Environ Health 13: 112, 2014

376.Maynard S, Keijzers G, Hansen ÅM, Osler M, Molbo D, Bendix L, Møller P, Loft S, Moreno-Villanueva M, Bürkle A, Hvitby GP, Schurman SH, Stevnsner T, Rasmussen LJ, Avlund K, Bohr VA. Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance. Acta Physiol 213: 156-70, 2015

377.Møller P, Hemmingsen JG, Jensen DM, Danielsen PH, Karottki DG, Jantzen K, Roursgaard M, Cao Y, Kermanizadeh A, Klingberg H, Christophersen DV, Hersoug LG, Loft S. Applications of the comet assay in particle toxicology: air pollution and engineered nanomaterials exposure. Mutagenesis 30: 67-83, 2015

378.Knudsen KB, Northeved H, Kumar P, Permin A, Andresen TL, Larsen S, Wegener KM, Lykkesfeldt J, Jantzen K,  Loft S, Møller P, Roursgaard M. In vivo toxicity of cationic micelles and liposomes. Nanomedicine 11: 467-77, 2015

379.Møller P, Jensen DM, Christophersen DV, Kermanizadeh A, Jacobsen NR, Hemmingsen JG, Danielsen PH, Karottki DG, Roursgaard M, Cao Y, Jantzen K, Klingberg H, Hersoug LG, Loft S. Measurement of oxidative damage to DNA in nanomaterial exposed cells and animals. Environ Mol Mutagen 56: 97-110, 2015

380.Karottki DG, Spilak M, Frederiksen M, Andersen ZJ, Madsen AM, Ketzel M, Massling A, Gunnarsen L, Møller P, Loft S. Indoor and Outdoor Exposure to Ultrafine, Fine and Microbiologically Derived Particulate Matter Related to Cardiovascular and Respiratory Effects in a panel of Elderly Urban Citizens. Int J Eviron Res Public Health. 12:1667-86, 2015

381.Cao Y, Roursgaard M, Kermanizadeh A, Loft S, Møller P. Synergistic effects of zinc oxide nanoparticle and fatty acid on toxicity to Caco-2 cells. Int J Toxicol 34: 67-76, 2015

382. Kermanizadeh A, Chauché C, Brown DM, Loft S, Møller P. The role of intracellular redox imbalance in nanomaterial induced cellular damage and genotoxicity - a review. Environ Mol Mutagen 56: 111-24, 2015

383.Løhr M, Jensen A, Eriksen L, Grønbæk M, Loft S, Møller P. Age and metabolic risk factors associated with oxidative damage to DNA in human peripheral blood mononuclear cells. Oncotarget 6:2641-2653, 2015

384.Forsberg K, Aalling N, Wörtwein G, Loft S, Møller P, Hau J, Hageman I, Jørgensen MB, Jørgensen A. Dynamic regulation of cerebral DNA repair genes by psychological stress. Mutat Res 778:37-43, 2015

385.Løhr M, Folkmann JK, Sheykhzade M, Jensen LJ,  Kermanizadeh A, Loft S, Møller P. Hepatic oxidative stress, genotoxicity and vascular dysfunction in lean or obese Zucker rats. PLoS One 10:e0118773, 2015

386.Klingberg H, Oddershede L, Loeschner K, Larsen EH, Loft S, Møller P. Uptake of gold nanoparticles in primary human endothelial cells. Toxicol Res 4: 655-666, 2015

387.Hemmingsen JG, Møller P, Jantzen K, Jönsson BA, Albin M, Wierzbicka A, Gudmundsson A, Loft S, Rissler J. Controlled exposure to diesel exhaust and traffic noise – effects on oxidative stress and activation in mononuclear blood cells. Mutation Res 775:66-71, 2015

388.Bekö G, Kjeldsen BU, Olsen Y, Schipperijn J, Wierzbicka A, Karottki DG, Toftum J, Loft S, Clausen G. Contribution of various microenvironments to the daily personal exposure to ultrafine particles: Personal monitoring coupled with GPS tracking. Atmospheric  Environ 110: 122-9, 2015

389.Hemmingsen JG, Rissler J, Lykkesfeldt J, Sallsten G, Kristiansen J, Møller  P, Loft S. Controlled exposure to particulate matter from urban street air is associated with decreased vasodilation and heart rate variability in overweight and older adults. Particle Fibre Toxicol 12: 6, 2015

390.Møller P, Yi C, Vesterdal LK, Danielsen PH, Roursgaard M, Klingberg H, Christophersen DV, Loft S. Carbon nanotubes and Cardiovascular Disease, pp 331-41. In Nanotoxicology: Progress Toward Nanomedicine, 2nd Edition. Eds. Monteriro-Riviere, Tran CL. CRC Press, Taylor and Francis Group, 2015

391.Klingberg H, Oddershede LB, Loft S, Møller P. Influence of flow, shear stress and adhesion molecule targeting on gold nanoparticle uptake in human endothelial cells. Nanoscale 7: 11409-19, 2015

392.Cao Y. Gouveia ACD, Skovmand A, Roursgaard M, Loft S, Møller P. Automobile diesel exhaust particles induce lipid droplet formation in macrophages in vitro. Environmental Toxicol Pharmacol 40: 164-71, 2015

393.Bräuner EV, Loft S, Sørensen M, Jensen A, Andersen CE, Ulbak K, Hertel O, Pedersen C, Tjønneland A, Krüger Kjær S, Raaschou-Nielsen O. Residential Radon Exposure and Skin Cancer Incidence in a Prospective Danish Cohort. PLoS One. 2015 Aug 14;10(8):e0135642

394.Lacoppidan SA, Kyrø C, Loft S, Helnæs A, Christensen J, Hansen CP, Dahm CC, Overvad K, Tjønneland A, Olsen A. Adherence to a Healthy Nordic Food Index Is Associated with a Lower Risk of Type-2 Diabetes-The Danish Diet, Cancer and Health Cohort Study. Nutrients 7: 8633-44, 2015

395.Danielsen PH, Cao Y, Roursgaard M, Møller P, Loft S. Endothelial cell activation, oxidative stress and inflammation induced by a panel of metal-based nanomaterials. Nanotoxicology 9: 813-24, 2015

396.Hemmingsen JG, Jantzen K, Møller P, Loft S. No oxidative stress or DNA damage in peripheral blood mononucler cells after exposure to particles from urban street air in overweight elderly. Mutagenesis 30: 635-42, 2015

397.Zhang L, Christensen SM,  Bendix PM, Bhatia VK, Loft S, Stamou D. Determining the Absolute Diameter of Single Gold Nanoparticles by an Interferometric Optical Approach. Small 11: 3550-5, 2015

398.Løhr M, Jensen A, Eriksen L, Grønbæk M. Loft S, Møller P. Association between age and repair of oxidatively damaged DNA in human peripheral blood mononuclear cells. Mutagenesis 30: 695-700, 2015

399.Kermanizadeh A, Balharry D, Wallin H, Loft S, Møller P. Nanomaterial translocation - the biokinetics, tissue accumulation, toxicity and fate of materials in secondary organs - a review. Crit Rev Toxicol 45: 837-7, 2015

400.Bräuner EV, Karottki DG, Frederiksen M, Kolarik B, Spilak M, Andersen ZJ, Vibenholt A, Ellermann T, Gunnarsen L Loft S. Residential Ozone and Lung Function in the Elderly. Indoor Built Environ 25, 93-105, 2016

401.Del Bo’C, Cao Y, Roursgaard M, Riso P, Porrini M, Loft S, and Møller P. Anthocyanins and phenolic acids from a wild blueberry (Vaccinium angustifolium) powder counteract lipid accumulation in THP-1 derived macrophages. Eur J Nutr 5: 171-82, 2016

402.Cao Y, Roursgaard M, Jacobsen NR, Møller P, Loft S. Monocyte adhesion induced by multi-walled carbon nanotubes and palmitic acid in endothelial cells and alveolar-endothelial co-cultures. Nanotoxicology 10: 235-44, 2016

403.Hersoug LG, Møller P, Loft S. Gut microbiota-derived lipopolysaccharide uptake and trafficking to adipose tissue: implications for inflammation and obesity. Obesity Rev 17: 297-312, 2016

404.Kermanizadeh A, Gosens I, Johnston H, Danielsen PH, Jacobsen NR, Lenz AG, Fernandes T, Schins RPF, Cassee FR, Wallin H, Keryling W, SToeger T, Loft S, Møller P, Tran L, Stone V. A multi-laboratory toxicological assessment of a panel of ten engineered nanomaterials to human health - ENPRA project - the good, the bad and the current and future challenges. J Toxicol Environ Health –Part B 19:1, 1-28, 2016

405.Møller P, Christophersen  DV, Jacobsen NR, Skovmand A, Gouveia ACD, Andersen MHG, Kermanizadeh A, Jensen DM, Danielsen PH, Roursgaard M, Jantzen K, Loft S. Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials. Crit Rev Toxicol 46: 437-76, 2016

406.Hansen AB, Ravnskjær L, Loft S, Andersen KK, Bräuner EB, Baastrup R, Yao C, Ketzel M, Beckerg T, Brandt J, Ole Hertel, Andersen ZJ. Long-term Exposure to Fine Particulate Matter and Incidence of Diabetes in the Danish Nurse Cohort. Environ Int 91:243-250, 2016

407.Fisher JE, Loft S, Ulrik CS, Raaschou-Nielsen O, Hertel O, Tjønneland A,Overvad K, Nieuwenhuijsen MJ, Andersen ZJ. Physical Activity, Air Pollution and the Risk of Asthma and Chronic Obstructive Pulmonary Disease. Am J Resp Crit Care Med.

408.Samoli E, Andersen ZJ, Katsouyanni K, Henning F, Kuhlbusch TAJ, Bellander R, Cattani G, Cyrus J, Forastiere F, Jacquemin B, Kulmala M, Lanki T, Loft S, Massling A, Tobias A, Stafoggia M, on behalf of the UF&HEALTH Study group. Exposure to ultrafine particles and respiratory hospitalizations in five European cities. Eur Resp J 48: 674-82, 2016

409.Monrad M, Sajadieh A, Christensen JS, Ketzel M, Raaschou-Nielsen O, Tjønneland A, Overvad K, Loft S, Sørensen M. Residential exposure to traffic noise and risk for incident atrial fibrillation: a cohort study. Environ Int 92-93: 457-63, 2016

410.Jørgensen JT, Johansen MS, Ravnskjær L, Andersen KK, Bräuner EV, Loft S, Ketzel M, Becker T, Brandt J, Hertel O, Andersen ZJ. Long-term Exposure to Ambient Air Pollution and Incidence of Brain Tumours: The Danish Nurse Cohort. Neurotoxicology 55: 122-30, 2016

411.Del Bo C, Roursgaard M, Porrini M, Loft S, Møller P, Riso P. Different effect of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF-α stimulated pro-inflammatory environment. Mol Nutr Food Res

412.Jantzen K, Møller P, Karottki DG, Olsen Y, Bekö G, Clausen G, Hersoug LG, Loft S. Exposure to ultrafine particles, intracellular production of reactive oxygen species in leukocytes and altered levels of endothelial progenitor cells. Toxicology 359-360: 11-18, 2016

413.Monrad M, Sajadieh A, Christensen JS, Ketzel M, Raaschou-Nielsen O, Tjønneland A, Overvad K, Loft S, Sørensen M. Long-Term Exposure to Traffic-Related Air Pollution and Risk of Incident Atrial Fibrillation: A Cohort Study. Environ Health Perspect

414.Roursgaard M, Knudsen KB, Northeved H, Persson M, Christensen T, Kumar PE, Permin A, Andresen TL, Gjetting T, Lykkesfeldt J, Vesterdal LK, Loft S, Møller P In vitro toxicity of cationic micelles and liposomes in cultured human hepatocyte (HepG2) and lung epithelial (A549) cell lines. Toxicol In Vitro 36: 164-71, 2016

415.Christophersen DV, Jacobsen NR, Jensen DM, Kermanizadeh A, Sheykhzade M, Loft S, Vogel U, Wallin H, Møller P. Inflammation and vascular effects after repeated intratracheal instillations of carbon black and lipopolysaccharide. Plos ONE 11: e0160731

416.Andersen ZA, Ravnskjær L, Andersen KK, Loft S, Brandt J, Becker T, Ketzel M, Hertel O, Lynge E, Bräuner EV. Long-Term Exposure to Fine Particulate Matter and Breast Cancer Incidence in the Danish Nurse Cohort Study. Cancer Epidemiol Biomarker Prev

417.Loft S. Reaping the Health Benefits of Tackling Environmental Change. Solutions 7: 21-24, 2016.

418.Møller KL, Brauer C, Mikkelsen S, Loft S, Simonsen EB, Koblauch H, Bern SH, Alkjær T, Hertel O, Becker T, Larsen KH, Bonde JP, Thygesen LC. Cohort Profile – The Copenhagen Airport Cohort  BMJ Open

419.Kermanizadeh A, Villadsen K, Østrem RG, Jensen KJ, Møller P, Loft S. Integrin targeting and toxicological assessment of peptide-conjugated liposome delivery systems to activated endothelial cells. Basic Clin Pharmacol Toxicol

420.Christophersen DV, Jacobsen NR, Andersen MHG, Connell SP, Barfod KK, Thomsen MB, Miller MR, Duffin R, Lykkesfeldt J, Vogel U, Wallin H, Loft S, Roursgaard M, Møller P.Cardiovascular health effects of oral and pulmonary exposure to multi-walled carbon nanotubes in ApoE-deficient mice. Toxicology

Kort præsentation

Fra januar 2015
Institutleder ved Institut for Folkesundhedsvidenskab, Københavns Universitet

Medlem af styregruppen for Københavns Universitets Center for Sustainability Science

Indtil 2015
Afdelingsleder i Afdeling for Miljø og Sundhed, Institut for Folkesundhedsvidenskab, Københavns Universitet

Indtil 2015
Medlem af Akademisk Råd for det Sundhedsvidenskabelige Fakultet, Københavns Universitet

Indtil 2014
Næstformand i bestyrelsen for Det Nationale Forskningscenter for Arbejdsmiljø

Primære forskningsområder

Steffen Loft forsker i toksikologi og hvordan kroppen optager og håndterer giftstoffer. Især studerer han effekten af partikler i luftforureningen og besidder desuden viden om kost og kræft samt de negative sundhedsmæssige aspekter af moderne industriel nanoteknologi.

Partikelforskningen omfatter såvel eksponering for og effekt af luftforurening ude og inde - som de teknologisk fremstillede, herunder medicinske, nanopartikler. Arbejdet spænder over hele hierarkiet af metoder; fra eksperimentelle modeller som syntetiske membraner, organotypiske cellekulturer og transgene dyr og over brug af biomarkører og funktionelle mål i befolkninger med kontrolleret eksponering og interventioner til registerbaseret epidemiologi på aggregeret niveau. Der er særlig opmærksomhed på mekanismer knyttet til oxidativt stress-relaterede genotoksiske og vaskulære effekter og risikogrupper, som genetisk disponerede, fostre, børn og ældre med og uden diabetes og/eller overvægt, samt regulering af forsvarsmekanismer som DNA-reparation.

Det molekylærepidemiologiske udviklingsarbejde omfatter mål for intern dosis af miljøfaktorer, effekter i form af oxidativt og kemisk stress, det cellulære respons i form af genekspressionsmønstre, resulterende DNA-skade og dertil knyttet reparationskapacitet, genetisk betinget følsomhed samt kardiovaskulær funktion. Biomarkører for eksponering og effekt appliceres i udsatte befolkningsgrupper og valideres for relation og prædiktiv værdi i forhold til sygdomsudvikling i store kohorter.

Blandt de seneste forskningsresultater kan nævnes: Demonstration af effekt af nanopartikler på oxidativ skade, på DNA og vaskulær funktion både i følsomme transgene dyremodeller og hos mennesker, og at en række af biomarkører for eksponering kan forudsige risikoen for kræft i prospektive befolkningsundersøgelser.