NNMT: A Bad Actor in Fat Makes Good in Liver

TY - JOUR

T1 - NNMT

T2 - A Bad Actor in Fat Makes Good in Liver

AU - Trammell, Samuel A.J.

AU - Brenner, Charles

PY - 2015/8/4

Y1 - 2015/8/4

N2 - High adipose expression of NNMT, an enzyme that converts nicotinamide to 1-methyl-nicotinamide, correlates with adiposity. Though murine NNMT knockdown in fat and liver prevents weight gain on high-fat diet, Hong et al. (2015) now show that high hepatic expression of NNMT improves lipid parameters via SIRT1 stabilization.

AB - High adipose expression of NNMT, an enzyme that converts nicotinamide to 1-methyl-nicotinamide, correlates with adiposity. Though murine NNMT knockdown in fat and liver prevents weight gain on high-fat diet, Hong et al. (2015) now show that high hepatic expression of NNMT improves lipid parameters via SIRT1 stabilization.

UR - http://www.scopus.com/inward/record.url?scp=84938593243&partnerID=8YFLogxK

U2 - 10.1016/j.cmet.2015.07.017

DO - 10.1016/j.cmet.2015.07.017

M3 - Editorial

C2 - 26244929

AN - SCOPUS:84938593243

SN - 1550-4131

VL - 22

SP - 200

EP - 201

JO - Cell Metabolism

JF - Cell Metabolism

IS - 2

ER -