Neural synchronization via potassium signaling

Dmitry E Postnov; Ludmila S Ryazanova; Erik Mosekilde; Olga Sosnovtseva

Neural synchronization via potassium signaling

Dmitry E Postnov, Ludmila S Ryazanova, Erik Mosekilde, Olga Sosnovtseva

Nyre- og Karforskning

11 Citationer (Scopus)

Abstract

Using a relatively simple model we examine how variations of the extracellular potassium concentration can give rise to synchronization of two nearby pacemaker cells. With the volume of the extracellular space and the rate of potassium diffusion as control parameters, the dual nature of this resource-mediated coupling is found to be responsible for the coexistence of competing patterns of in- and anti-phase synchronization between identical cells. Cell heterogeneity produces significant modifications of the dynamical regimes in the control parameter plane. By comparison with conventional gap junctional coupling, potassium signaling gives rise to considerable changes of the cellular response to external stimuli.

Originalsprog	Engelsk
Tidsskrift	International Journal of Neural Systems
Vol/bind	16
Udgave nummer	2
Sider (fra-til)	99-109
Antal sider	11
ISSN	0129-0657
Status	Udgivet - 1 apr. 2006

Citationsformater

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title = "Neural synchronization via potassium signaling",

abstract = "Using a relatively simple model we examine how variations of the extracellular potassium concentration can give rise to synchronization of two nearby pacemaker cells. With the volume of the extracellular space and the rate of potassium diffusion as control parameters, the dual nature of this resource-mediated coupling is found to be responsible for the coexistence of competing patterns of in- and anti-phase synchronization between identical cells. Cell heterogeneity produces significant modifications of the dynamical regimes in the control parameter plane. By comparison with conventional gap junctional coupling, potassium signaling gives rise to considerable changes of the cellular response to external stimuli.",

keywords = "Animals, Biological Clocks, Gap Junctions, Humans, Models, Neurological, Nerve Net, Neural Pathways, Neuroglia, Neurons, Periodicity, Potassium Channels, Signal Transduction",

author = "Postnov, {Dmitry E} and Ryazanova, {Ludmila S} and Erik Mosekilde and Olga Sosnovtseva",

year = "2006",

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language = "English",

volume = "16",

pages = "99--109",

journal = "International Journal of Neural Systems",

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TY - JOUR

T1 - Neural synchronization via potassium signaling

AU - Postnov, Dmitry E

AU - Ryazanova, Ludmila S

AU - Mosekilde, Erik

AU - Sosnovtseva, Olga

PY - 2006/4/1

Y1 - 2006/4/1

N2 - Using a relatively simple model we examine how variations of the extracellular potassium concentration can give rise to synchronization of two nearby pacemaker cells. With the volume of the extracellular space and the rate of potassium diffusion as control parameters, the dual nature of this resource-mediated coupling is found to be responsible for the coexistence of competing patterns of in- and anti-phase synchronization between identical cells. Cell heterogeneity produces significant modifications of the dynamical regimes in the control parameter plane. By comparison with conventional gap junctional coupling, potassium signaling gives rise to considerable changes of the cellular response to external stimuli.

AB - Using a relatively simple model we examine how variations of the extracellular potassium concentration can give rise to synchronization of two nearby pacemaker cells. With the volume of the extracellular space and the rate of potassium diffusion as control parameters, the dual nature of this resource-mediated coupling is found to be responsible for the coexistence of competing patterns of in- and anti-phase synchronization between identical cells. Cell heterogeneity produces significant modifications of the dynamical regimes in the control parameter plane. By comparison with conventional gap junctional coupling, potassium signaling gives rise to considerable changes of the cellular response to external stimuli.

KW - Animals

KW - Biological Clocks

KW - Gap Junctions

KW - Humans

KW - Models, Neurological

KW - Nerve Net

KW - Neural Pathways

KW - Neuroglia

KW - Neurons

KW - Periodicity

KW - Potassium Channels

KW - Signal Transduction

M3 - Journal article

C2 - 16688850

SN - 0129-0657

VL - 16

SP - 99

EP - 109

JO - International Journal of Neural Systems

JF - International Journal of Neural Systems

IS - 2

ER -

Neural synchronization via potassium signaling

Abstract

Fingeraftryk

Citationsformater