Natural products from microbes associated with insects

TY - JOUR

T1 - Natural products from microbes associated with insects

AU - Beemelmanns, Christine

AU - Guo, Huijuan

AU - Rischer, Maja

AU - Thomas-Poulsen, Michael

PY - 2016/2/19

Y1 - 2016/2/19

N2 - Here we review discoveries of secondary metabolites from microbes associated with insects. We mainly focus on natural products, where the ecological role has been at least partially elucidated, and/or the pharmaceutical properties evaluated, and on compounds with unique structural features. We demonstrate that the exploration of specific microbial-host interactions, in combination with multidisciplinary dereplication processes, has emerged as a successful strategy to identify novel chemical entities and to shed light on the ecology and evolution of defensive associations.

AB - Here we review discoveries of secondary metabolites from microbes associated with insects. We mainly focus on natural products, where the ecological role has been at least partially elucidated, and/or the pharmaceutical properties evaluated, and on compounds with unique structural features. We demonstrate that the exploration of specific microbial-host interactions, in combination with multidisciplinary dereplication processes, has emerged as a successful strategy to identify novel chemical entities and to shed light on the ecology and evolution of defensive associations.

U2 - 10.3762/bjoc.12.34

DO - 10.3762/bjoc.12.34

M3 - Journal article

C2 - 26977191

SN - 2195-951X

VL - 12

SP - 314

EP - 327

JO - Beilstein Journal of Organic Chemistry

JF - Beilstein Journal of Organic Chemistry

ER -