TY - JOUR
T1 - Mitophagy in neurodegeneration and aging
AU - Fivenson, Elayne M
AU - Lautrup, Sofie
AU - Sun, Nuo
AU - Scheibye-Knudsen, Morten
AU - Stevnsner, Tinna
AU - Nilsen, Hilde
AU - Bohr, Vilhelm A
AU - Fang, Evandro Fei
N1 - Published by Elsevier Ltd.
PY - 2017/10
Y1 - 2017/10
N2 - Mitochondrial dysfunction contributes to normal aging and a wide spectrum of age-related diseases, including neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease. It is important to maintain a healthy mitochondrial population which is tightly regulated by proteolysis and mitophagy. Mitophagy is a specialized form of autophagy that regulates the turnover of damaged and dysfunctional mitochondria, organelles that function in producing energy for the cell in the form of ATP and regulating energy homeostasis. Mechanistic studies on mitophagy across species highlight a sophisticated and integrated cellular network that regulates the degradation of mitochondria. Strategies directed at maintaining a healthy mitophagy level in aged individuals might have beneficial effects. In this review, we provide an updated mechanistic overview of mitophagy pathways and discuss the role of reduced mitophagy in neurodegeneration. We also highlight potential translational applications of mitophagy-inducing compounds, such as NAD(+) precursors and urolithins.
AB - Mitochondrial dysfunction contributes to normal aging and a wide spectrum of age-related diseases, including neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease. It is important to maintain a healthy mitochondrial population which is tightly regulated by proteolysis and mitophagy. Mitophagy is a specialized form of autophagy that regulates the turnover of damaged and dysfunctional mitochondria, organelles that function in producing energy for the cell in the form of ATP and regulating energy homeostasis. Mechanistic studies on mitophagy across species highlight a sophisticated and integrated cellular network that regulates the degradation of mitochondria. Strategies directed at maintaining a healthy mitophagy level in aged individuals might have beneficial effects. In this review, we provide an updated mechanistic overview of mitophagy pathways and discuss the role of reduced mitophagy in neurodegeneration. We also highlight potential translational applications of mitophagy-inducing compounds, such as NAD(+) precursors and urolithins.
U2 - 10.1016/j.neuint.2017.02.007
DO - 10.1016/j.neuint.2017.02.007
M3 - Review
C2 - 28235551
SN - 0197-0186
VL - 109
SP - 202
EP - 209
JO - Neurochemistry International
JF - Neurochemistry International
ER -