MicroRNAs in Drosophila Cancer Models

TY - CHAP

T1 - MicroRNAs in Drosophila Cancer Models

AU - Sander, Moritz

AU - Herranz, Héctor

PY - 2019

Y1 - 2019

N2 - MiRNAs are post-transcriptional regulators of gene expression which have been implicated in virtually all biological processes. MiRNAs are frequently dysregulated in human cancers. However, the functional consequences of aberrant miRNA levels are not well understood. Drosophila is emerging as an important in vivo tumor model, especially in the identification of novel cancer genes. Here, we review Drosophila studies which functionally dissect the roles of miRNAs in tumorigenesis. Ultimately, these advances help to understand the implications of miRNA dysregulation in human cancers.

AB - MiRNAs are post-transcriptional regulators of gene expression which have been implicated in virtually all biological processes. MiRNAs are frequently dysregulated in human cancers. However, the functional consequences of aberrant miRNA levels are not well understood. Drosophila is emerging as an important in vivo tumor model, especially in the identification of novel cancer genes. Here, we review Drosophila studies which functionally dissect the roles of miRNAs in tumorigenesis. Ultimately, these advances help to understand the implications of miRNA dysregulation in human cancers.

KW - Animal models

KW - Bantam

KW - Cancer

KW - Drosophila

KW - let-7

KW - miR-7

KW - miR-8

KW - miRNAs

KW - Oncogenic cooperation

U2 - 10.1007/978-3-030-23629-8_9

DO - 10.1007/978-3-030-23629-8_9

M3 - Book chapter

C2 - 31520354

AN - SCOPUS:85072186523

SN - 978-3-030-23628-1

VL - 1167

T3 - Advances in Experimental Medicine and Biology

SP - 157

EP - 173

BT - The Drosophila Model in Cancer

PB - Springer

ER -