Marine oil supplements for arthritis pain: A systematic review and meta-analysis of randomized trials

TY - JOUR

T1 - Marine oil supplements for arthritis pain

T2 - A systematic review and meta-analysis of randomized trials

AU - Senftleber, Ninna K.

AU - Nielsen, Sabrina M.

AU - Andersen, Jens Rikardt

AU - Bliddal, Henning

AU - Tarp, Simon

AU - Lauritzen, Lotte

AU - Furst, Daniel E

AU - Suarez-Almazor, Maria E

AU - Lyddiatt, Anne

AU - Christensen, Robin

N1 - CURIS 2017 NEXS 026

PY - 2017/1/6

Y1 - 2017/1/6

N2 - Arthritis patients often take fish oil supplements to alleviate symptoms, but limited evidence exists regarding their efficacy. The objective was to evaluate whether marine oil supplements reduce pain and/or improve other clinical outcomes in patients with arthritis. Six databases were searched systematically (24 February 2015). We included randomized trials of oral supplements of allmarine oils compared with a control in arthritis patients. The internal validity was assessed using the Cochrane Risk of Bias tool and heterogeneity was explored using restricted maximum of likelihood (REML)-based meta-regression analysis. Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to rate the overall quality of the evidence. Forty-two trials were included; 30 trials reported complete data on pain. The standardized mean difference (SMD) suggested a favorable effect (-0.24; 95% confidence interval, CI, -0.42 to -0.07; heterogeneity, I2 = 63%. A significant effect was found in patients with rheumatoid arthritis (22 trials; -0.21; 95% CI, -0.42 to -0.004) and other or mixed diagnoses (3 trials; -0.63; 95% CI, -1.20 to -0.06), but not in osteoarthritis patients (5 trials; -0.17; 95% CI, -0.57–0.24). The evidence for using marine oil toalleviate pain in arthritis patients was overall of low quality, but of moderate quality in rheumatoid arthritis patients.

AB - Arthritis patients often take fish oil supplements to alleviate symptoms, but limited evidence exists regarding their efficacy. The objective was to evaluate whether marine oil supplements reduce pain and/or improve other clinical outcomes in patients with arthritis. Six databases were searched systematically (24 February 2015). We included randomized trials of oral supplements of allmarine oils compared with a control in arthritis patients. The internal validity was assessed using the Cochrane Risk of Bias tool and heterogeneity was explored using restricted maximum of likelihood (REML)-based meta-regression analysis. Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to rate the overall quality of the evidence. Forty-two trials were included; 30 trials reported complete data on pain. The standardized mean difference (SMD) suggested a favorable effect (-0.24; 95% confidence interval, CI, -0.42 to -0.07; heterogeneity, I2 = 63%. A significant effect was found in patients with rheumatoid arthritis (22 trials; -0.21; 95% CI, -0.42 to -0.004) and other or mixed diagnoses (3 trials; -0.63; 95% CI, -1.20 to -0.06), but not in osteoarthritis patients (5 trials; -0.17; 95% CI, -0.57–0.24). The evidence for using marine oil toalleviate pain in arthritis patients was overall of low quality, but of moderate quality in rheumatoid arthritis patients.

KW - Faculty of Science

KW - Arthritis

KW - Marine oil

KW - Fish oil

KW - Joint pain

KW - Rheumatology

KW - Complementary medicine

KW - Meta-analysis

KW - Randomized controlled trial

U2 - 10.3390/nu9010042

DO - 10.3390/nu9010042

M3 - Review

C2 - 28067815

SN - 2072-6643

VL - 42

JO - Nutrients

JF - Nutrients

IS - 1

M1 - 42

ER -