Lysyl oxidase mediates hypoxic control of metastasis

TY - JOUR

T1 - Lysyl oxidase mediates hypoxic control of metastasis

AU - Erler, Janine Terra

AU - Giaccia, Amato J

PY - 2006/11/1

Y1 - 2006/11/1

N2 - Hypoxic cancer cells pose a great challenge to the oncologist because they are especially aggressive, metastatic, and resistant to therapy. Recently, we showed that elevation of the extracellular matrix protein lysyl oxidase (LOX) correlates with metastatic disease and is essential for hypoxia-induced metastasis. In an orthotopic rodent model of breast cancer, a small-molecule or antibody inhibitor of LOX abolished metastasis, offering preclinical validation of this enzyme as a therapeutic target.

AB - Hypoxic cancer cells pose a great challenge to the oncologist because they are especially aggressive, metastatic, and resistant to therapy. Recently, we showed that elevation of the extracellular matrix protein lysyl oxidase (LOX) correlates with metastatic disease and is essential for hypoxia-induced metastasis. In an orthotopic rodent model of breast cancer, a small-molecule or antibody inhibitor of LOX abolished metastasis, offering preclinical validation of this enzyme as a therapeutic target.

KW - Breast Neoplasms

KW - Cell Hypoxia

KW - Cell Proliferation

KW - Humans

KW - Neoplasm Invasiveness

KW - Neoplasm Metastasis

KW - Protein-Lysine 6-Oxidase

U2 - 10.1158/0008-5472.CAN-06-3197

DO - 10.1158/0008-5472.CAN-06-3197

M3 - Journal article

C2 - 17079439

SN - 0008-5472

VL - 66

SP - 10238

EP - 10241

JO - Cancer Research

JF - Cancer Research

IS - 21

ER -