Lysyl oxidase mediates hypoxic control of metastasis

Janine Terra Erler; Amato J Giaccia

doi:10.1158/0008-5472.CAN-06-3197

Lysyl oxidase mediates hypoxic control of metastasis

152 Citations (Scopus)

Abstract

Hypoxic cancer cells pose a great challenge to the oncologist because they are especially aggressive, metastatic, and resistant to therapy. Recently, we showed that elevation of the extracellular matrix protein lysyl oxidase (LOX) correlates with metastatic disease and is essential for hypoxia-induced metastasis. In an orthotopic rodent model of breast cancer, a small-molecule or antibody inhibitor of LOX abolished metastasis, offering preclinical validation of this enzyme as a therapeutic target.

Original language	English
Journal	Cancer Research
Volume	66
Issue number	21
Pages (from-to)	10238-41
Number of pages	4
ISSN	0008-5472
DOIs	https://doi.org/10.1158/0008-5472.CAN-06-3197
Publication status	Published - 1 Nov 2006
Externally published	Yes

Keywords

Breast Neoplasms
Cell Hypoxia
Cell Proliferation
Humans
Neoplasm Invasiveness
Neoplasm Metastasis
Protein-Lysine 6-Oxidase

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1158/0008-5472.CAN-06-3197

Cite this

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abstract = "Hypoxic cancer cells pose a great challenge to the oncologist because they are especially aggressive, metastatic, and resistant to therapy. Recently, we showed that elevation of the extracellular matrix protein lysyl oxidase (LOX) correlates with metastatic disease and is essential for hypoxia-induced metastasis. In an orthotopic rodent model of breast cancer, a small-molecule or antibody inhibitor of LOX abolished metastasis, offering preclinical validation of this enzyme as a therapeutic target.",

keywords = "Breast Neoplasms, Cell Hypoxia, Cell Proliferation, Humans, Neoplasm Invasiveness, Neoplasm Metastasis, Protein-Lysine 6-Oxidase",

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AU - Erler, Janine Terra

AU - Giaccia, Amato J

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AB - Hypoxic cancer cells pose a great challenge to the oncologist because they are especially aggressive, metastatic, and resistant to therapy. Recently, we showed that elevation of the extracellular matrix protein lysyl oxidase (LOX) correlates with metastatic disease and is essential for hypoxia-induced metastasis. In an orthotopic rodent model of breast cancer, a small-molecule or antibody inhibitor of LOX abolished metastasis, offering preclinical validation of this enzyme as a therapeutic target.

KW - Breast Neoplasms

KW - Cell Hypoxia

KW - Cell Proliferation

KW - Humans

KW - Neoplasm Invasiveness

KW - Neoplasm Metastasis

KW - Protein-Lysine 6-Oxidase

U2 - 10.1158/0008-5472.CAN-06-3197

DO - 10.1158/0008-5472.CAN-06-3197

M3 - Journal article

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VL - 66

SP - 10238

EP - 10241

JO - Cancer Research

JF - Cancer Research

IS - 21

ER -

Lysyl oxidase mediates hypoxic control of metastasis

Abstract

Keywords

UN SDGs

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