TY - JOUR
T1 - Long Non-Coding RNAs Guide the Fine-Tuning of Gene Regulation in B-Cell Development and Malignancy
AU - Dahl, Mette
AU - Kristensen, Lasse Sommer
AU - Grønbæk, Kirsten
PY - 2018/9
Y1 - 2018/9
N2 - With the introduction of next generation sequencing methods, such as RNA sequencing, it has become apparent that alterations in the non-coding regions of our genome are important in the development of cancer. Particularly interesting is the class of long non-coding RNAs (lncRNAs), including the recently described subclass of circular RNAs (circRNAs), which display tissue- and cell-type specific expression patterns and exert diverse regulatory functions in the cells. B-cells undergo complex and tightly regulated processes in order to develop from antigen naïve cells residing in the bone marrow to the highly diverse and competent effector cells circulating in peripheral blood. These processes include V(D)J recombination, rapid proliferation, somatic hypermutation and clonal selection, posing a risk of malignant transformation at each step. The aim of this review is to provide insight into how lncRNAs including circRNAs, participate in normal B-cell differentiation, and how deregulation of these molecules is involved in the development of B-cell malignancies. We describe the prognostic value and functional significance of specific deregulated lncRNAs in diseases such as acute lymphoblastic leukemia, chronic lymphocytic leukemia, mantle cell lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, Burkitt lymphoma and multiple myeloma, and we provide an overview of the current knowledge on the role of circRNAs in these diseases.
AB - With the introduction of next generation sequencing methods, such as RNA sequencing, it has become apparent that alterations in the non-coding regions of our genome are important in the development of cancer. Particularly interesting is the class of long non-coding RNAs (lncRNAs), including the recently described subclass of circular RNAs (circRNAs), which display tissue- and cell-type specific expression patterns and exert diverse regulatory functions in the cells. B-cells undergo complex and tightly regulated processes in order to develop from antigen naïve cells residing in the bone marrow to the highly diverse and competent effector cells circulating in peripheral blood. These processes include V(D)J recombination, rapid proliferation, somatic hypermutation and clonal selection, posing a risk of malignant transformation at each step. The aim of this review is to provide insight into how lncRNAs including circRNAs, participate in normal B-cell differentiation, and how deregulation of these molecules is involved in the development of B-cell malignancies. We describe the prognostic value and functional significance of specific deregulated lncRNAs in diseases such as acute lymphoblastic leukemia, chronic lymphocytic leukemia, mantle cell lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, Burkitt lymphoma and multiple myeloma, and we provide an overview of the current knowledge on the role of circRNAs in these diseases.
KW - B-Lymphocytes/immunology
KW - Burkitt Lymphoma/genetics
KW - Cell Differentiation
KW - Cell Transformation, Neoplastic/genetics
KW - Gene Expression Regulation, Neoplastic
KW - Humans
KW - Leukemia, Lymphocytic, Chronic, B-Cell/genetics
KW - Lymphoma, Follicular/genetics
KW - Lymphoma, Large B-Cell, Diffuse/genetics
KW - Lymphoma, Mantle-Cell/genetics
KW - Multiple Myeloma/genetics
KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics
KW - RNA/genetics
KW - RNA, Long Noncoding/genetics
KW - Signal Transduction
U2 - 10.3390/ijms19092475
DO - 10.3390/ijms19092475
M3 - Review
C2 - 30134619
SN - 1661-6596
VL - 19
JO - International Journal of Molecular Sciences (Online)
JF - International Journal of Molecular Sciences (Online)
IS - 9
M1 - 2475
ER -
