Light sensitive chloramphenicol analogues

V Leick; O Buchardt; Peter E. Nielsen

Light sensitive chloramphenicol analogues

Transcription, RNA, and Gene Medicine Program

13 Citationer (Scopus)

Abstract

Some chloramphenicol analogues have been prepared in order to find reagents which could be used in a photoaffinity labelling study of the peptidayl transferase center of the E. coli ribosome. The compounds were tested for antibiotic activity in vitro in the "fragment reaction" assay, and for their ability to generate very reactive species upon irradiation.

Originalsprog	Engelsk
Tidsskrift	Dalton Transactions (Print Edition)
Vol/bind	29
Udgave nummer	6
Sider (fra-til)	662-6
Antal sider	5
ISSN	0302-4369
Status	Udgivet - 1975

Citationsformater

@article{fe07781c163148bfbfe3d1733a3b954e,

title = "Light sensitive chloramphenicol analogues",

abstract = "Some chloramphenicol analogues have been prepared in order to find reagents which could be used in a photoaffinity labelling study of the peptidayl transferase center of the E. coli ribosome. The compounds were tested for antibiotic activity in vitro in the {"}fragment reaction{"} assay, and for their ability to generate very reactive species upon irradiation.",

keywords = "Chloramphenicol/analogs & derivatives, Depression, Chemical, Escherichia coli/enzymology, Light, Peptidyl Transferases/metabolism, Photochemistry, Radiation Effects, Ribosomes/enzymology, Ultraviolet Rays",

author = "V Leick and O Buchardt and Nielsen, {Peter E.}",

year = "1975",

language = "English",

volume = "29",

pages = "662--6",

journal = "Acta chemica Scandinavica. Series A: Physical and inorganic chemistry",

issn = "1477-9226",

publisher = "Royal Society of Chemistry",

number = "6",

}

TY - JOUR

T1 - Light sensitive chloramphenicol analogues

AU - Leick, V

AU - Buchardt, O

AU - Nielsen, Peter E.

PY - 1975

Y1 - 1975

N2 - Some chloramphenicol analogues have been prepared in order to find reagents which could be used in a photoaffinity labelling study of the peptidayl transferase center of the E. coli ribosome. The compounds were tested for antibiotic activity in vitro in the "fragment reaction" assay, and for their ability to generate very reactive species upon irradiation.

AB - Some chloramphenicol analogues have been prepared in order to find reagents which could be used in a photoaffinity labelling study of the peptidayl transferase center of the E. coli ribosome. The compounds were tested for antibiotic activity in vitro in the "fragment reaction" assay, and for their ability to generate very reactive species upon irradiation.

KW - Chloramphenicol/analogs & derivatives

KW - Depression, Chemical

KW - Escherichia coli/enzymology

KW - Light

KW - Peptidyl Transferases/metabolism

KW - Photochemistry

KW - Radiation Effects

KW - Ribosomes/enzymology

KW - Ultraviolet Rays

M3 - Journal article

C2 - 1103535

SN - 1477-9226

VL - 29

SP - 662

EP - 666

JO - Acta chemica Scandinavica. Series A: Physical and inorganic chemistry

JF - Acta chemica Scandinavica. Series A: Physical and inorganic chemistry

IS - 6

ER -

Light sensitive chloramphenicol analogues

Abstract

Fingeraftryk

Citationsformater