Kif7 keeps cilia tips in shape

Lotte Bang Pedersen; Anna Akhmanova

doi:10.1038/ncb2997

Kif7 keeps cilia tips in shape

Lotte Bang Pedersen, Anna Akhmanova

Cellebiologi og Fysiologi

9 Citationer (Scopus)

Abstract

The kinesin-4 motor protein Kif7 regulates Hedgehog signalling at cilia in mammals by controlling the activity of Gli transcription factors. Kif7 is now found to inhibit microtubule growth to restrict and coordinate the length of axonemal microtubules at the ciliary tip. Such Kif7-mediated organization of the ciliary tip compartment regulates Gli activity and is proposed to be required for correct Hedgehog signalling.

Originalsprog	Engelsk
Tidsskrift	Nature Cell Biology
Vol/bind	16
Udgave nummer	7
Sider (fra-til)	623-625
Antal sider	3
ISSN	1465-7392
DOI	https://doi.org/10.1038/ncb2997
Status	Udgivet - jul. 2014

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10.1038/ncb2997

http://www.nature.com/ncb/journal/v16/n7/full/ncb2997.html

Citationsformater

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abstract = "The kinesin-4 motor protein Kif7 regulates Hedgehog signalling at cilia in mammals by controlling the activity of Gli transcription factors. Kif7 is now found to inhibit microtubule growth to restrict and coordinate the length of axonemal microtubules at the ciliary tip. Such Kif7-mediated organization of the ciliary tip compartment regulates Gli activity and is proposed to be required for correct Hedgehog signalling.",

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AB - The kinesin-4 motor protein Kif7 regulates Hedgehog signalling at cilia in mammals by controlling the activity of Gli transcription factors. Kif7 is now found to inhibit microtubule growth to restrict and coordinate the length of axonemal microtubules at the ciliary tip. Such Kif7-mediated organization of the ciliary tip compartment regulates Gli activity and is proposed to be required for correct Hedgehog signalling.

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JO - Nature Cell Biology

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Kif7 keeps cilia tips in shape

Abstract

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