TY - JOUR
T1 - Is Pelvic Inflammatory Disease a Risk Factor for Ovarian Cancer?
AU - Rasmussen, Christina B
AU - Jensen, Allan
AU - Albieri, Vanna
AU - Andersen, Klaus K
AU - Kjaer, Susanne K
N1 - ©2016 American Association for Cancer Research.
PY - 2017/1
Y1 - 2017/1
N2 - Background: Pelvic inflammatory disease (PID) has been proposed as a risk factor for ovarian cancer. However, the existing literature on the association between PID and ovarian cancer risk is inconclusive, and only few cohort studies have been conducted. Methods: Using nationwide Danish registries, we conducted a population-based cohort study including all women from the birth cohorts 1940 to 1970 in Denmark during 1978- 2012 (n =1,318,929) to investigate the association between PID and subsequent risk of epithelial ovarian cancer. Among women in the cohort, 81,281 women were diagnosed with PID and 5,356 women developed ovarian cancer during follow-up through 2012. Cox regression models were used to estimate HRs and 95% confidence intervals (CI) for the association between PID and ovarian cancer, both overall and according to histotype. Results: For ovarian cancer overall, we observed no association with PID (HR, 1.05; 95% CI, 0.92-1.20). However, in histotypespecific analyses, we found a statistically significantly increased risk of serous ovarian cancer among women with PID (HR, 1.19; 1.00-1.41; P =0.047). Conversely, PID was not convincingly associatedwith risk of any of the other histotypes of ovarian cancer. Conclusions: PID was associated with a modestly increased risk of serous ovarian cancer, but not other histotypes. Impact: Our results indicate that PID is not a strong risk factor for ovarian cancer. Whether PID is slightly associated with risk of serous ovarian cancer has to be confirmed in other studies.
AB - Background: Pelvic inflammatory disease (PID) has been proposed as a risk factor for ovarian cancer. However, the existing literature on the association between PID and ovarian cancer risk is inconclusive, and only few cohort studies have been conducted. Methods: Using nationwide Danish registries, we conducted a population-based cohort study including all women from the birth cohorts 1940 to 1970 in Denmark during 1978- 2012 (n =1,318,929) to investigate the association between PID and subsequent risk of epithelial ovarian cancer. Among women in the cohort, 81,281 women were diagnosed with PID and 5,356 women developed ovarian cancer during follow-up through 2012. Cox regression models were used to estimate HRs and 95% confidence intervals (CI) for the association between PID and ovarian cancer, both overall and according to histotype. Results: For ovarian cancer overall, we observed no association with PID (HR, 1.05; 95% CI, 0.92-1.20). However, in histotypespecific analyses, we found a statistically significantly increased risk of serous ovarian cancer among women with PID (HR, 1.19; 1.00-1.41; P =0.047). Conversely, PID was not convincingly associatedwith risk of any of the other histotypes of ovarian cancer. Conclusions: PID was associated with a modestly increased risk of serous ovarian cancer, but not other histotypes. Impact: Our results indicate that PID is not a strong risk factor for ovarian cancer. Whether PID is slightly associated with risk of serous ovarian cancer has to be confirmed in other studies.
KW - Adult
KW - Age Factors
KW - Cell Transformation, Neoplastic/pathology
KW - Cohort Studies
KW - Confidence Intervals
KW - Denmark
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Incidence
KW - Middle Aged
KW - Neoplasms, Glandular and Epithelial/epidemiology
KW - Ovarian Neoplasms/epidemiology
KW - Pelvic Inflammatory Disease/epidemiology
KW - Proportional Hazards Models
KW - Registries
KW - Retrospective Studies
KW - Risk Factors
KW - Time Factors
U2 - 10.1158/1055-9965.epi-16-0459
DO - 10.1158/1055-9965.epi-16-0459
M3 - Journal article
C2 - 27672055
SN - 1055-9965
VL - 26
SP - 104
EP - 109
JO - Cancer Epidemiology, Biomarkers & Prevention
JF - Cancer Epidemiology, Biomarkers & Prevention
IS - 1
ER -
