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Investigating the Conformational Response of the Sortilin Receptor upon Binding Endogenous Peptide- and Protein Ligands by HDX-MS
Esben Trabjerg
, Nadia Abu-Asad, Ziqian Wan, Fredrik Kartberg, Søren Christensen,
Kasper D Rand
8
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Keyphrases
Hydrogen-deuterium Exchange Mass Spectrometry
100%
Peptide Ligand
100%
Protein-ligand
100%
Endogenous Peptides
100%
Sortilin
100%
Endogenous Protein
100%
Neurotensin
22%
Binding Region
11%
Neurotrophic Factors
11%
Endogenous Ligand
11%
Crystallographic Study
11%
Structural Characterization
11%
Neurobiology
11%
Propeller
11%
Binding Site
11%
Nerve Growth Factor
11%
Apoptotic Pathway
11%
Ligand-dependent
11%
Dependency Function
11%
Propeptide
11%
Neuronal Receptors
11%
Neuropeptides
11%
Biochemistry, Genetics and Molecular Biology
Protein Ligand
100%
Neurotensin
100%
Hydrogen/Deuterium Exchange Mass Spectrometry
100%
Neurotrophic Factor
50%
Programmed Cell Death
50%
Binding Site
50%
Neuropeptide
50%
Nerve Growth Factor
50%
Ligand Binding
50%