@article{9b70060097ad11de8bc9000ea68e967b,
title = "Introduction of an single nucleodite polymorphism-based {"}Major Y-chromosome haplogroup typing kit{"} suitable for predicting the geographical origin of male lineages",
abstract = "The European Consortium {"}High-throughput analysis of single nucleotide polymorphisms for the forensic identification of persons--SNPforID{"}, has performed a selection of candidate Y-chromosome single nucleotide polymorphisms (SNPs) for making inferences on the geographic origin of an unknown sample. From more than 200 SNPs compiled in the phylogenetic tree published by the Y-Chromosome Consortium, and looking at the population studies previously published, a package of 29 SNPs has been selected for the identification of major population haplogroups. A {"}Major Y-chromosome haplogroup typing kit{"} has been developed, which allows the multiplex amplification of all 29 SNPs in a single reaction. Allele genotyping was performed with a single base extension reaction (minisequencing) detected by CE. The validation of the multiplex was performed in a total of 1126 unrelated males distributed among 12 worldwide populations. The approach takes advantage of the specific geographic distribution of the Y-chromosome haplogroups and demonstrates the utility of binary polymorphisms to infer the origin of a male lineage.",
author = "Mar{\'i}a Bri{\'o}n and Sanchez, {Juan J} and Kinga Balogh and Catherine Thacker and Alejandro Blanco-Verea and Claus B{\o}rsting and Beate Stradmann-Bellinghausen and Magdalena Bogus and Denise Syndercombe-Court and Schneider, {Peter M} and Angel Carracedo and Niels Morling",
note = "Keywords: Africa; Asia; Chromosomes, Human, Y; DNA Primers; Europe; Female; Genetics, Population; Haplotypes; Humans; Male; Phylogeny; Polymorphism, Single Nucleotide; South America",
year = "2005",
doi = "10.1002/elps.200500293",
language = "English",
volume = "26",
pages = "4411--20",
journal = "Electrophoresis",
issn = "0173-0835",
publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",
number = "23",
}